The Hippo signaling pathway is an intracellular kinase cascade in which
hpo kinase in complex with
sav, phosphorylates
wts kinase which, in turn, phosphorylates
yki transcriptional co-activator leading to its cytosolic retention. Positive regulators of the pathway, enhance the cytosolic retention of
yki, negatively regulating tissue growth (Adapted from
FBrf0224870).