Gene Group: UBIQUITIN-LIKE PROTEINS

General Information

Name

UBIQUITIN-LIKE PROTEINS

Species

D. melanogaster

Symbol

UBL

FlyBase ID

FBgg0001751

Date last reviewed

2021-08-02

Number of members

Description

Ubiquitin-like proteins (UBLs) include ubiquitin and other evolutionarily related proteins that share the ubiquitin fold and the capacity to be conjugated to substrates through a cascade of E1 activating enzymes, E2 conjugating enzymes, and E3 ligases. Conjugation of UBLs to target proteins or lipids regulate their activity, stability, subcellular localization, or macromolecular interactions. (Adapted from PMID:28234446.)

Notes on Group

D. melanogaster lacks homologs of the mammalian Ubiquitin-like proteins FAT10 and ISG15.

Source Material

The UBIQUITIN-LIKE PROTEINS Gene Group has been compiled using the following publication(s): Yu et al., 2020, Khoshnood et al., 2017, Pirone et al., 2017, Duan et al., 2016, Khoshnood et al., 2016, Ureña et al., 2016, Nagy et al., 2015, Lu et al., 2013, Smith et al., 2012, Zhan et al., 2012, Hoe et al., 2011, Zirin and Perrimon, 2010, Nie et al., 2009, Marygold, 2007.1.12, Ou et al., 2002, Shih et al., 2002, Bhaskar et al., 2000, and Izquierdo, 1994 .

Key Gene Ontology (GO) terms

Molecular Function

protein tag activity

Biological Process

protein modification by small protein conjugation

Cellular Component

Related Gene Groups

Component group(s)

Members (12)

For all members:

GO ribbon stack

	molecular function	biological process	cellular component

ATG8 PROTEINS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Atg8a

Autophagy-related 8a

Atg8, LC3, Autophagy-specific gene 8a, Atg-8a, DrAtg8a

(Nagy et al., 2015, Zirin and Perrimon, 2010)

Atg8b

Autophagy-related 8b

Atg8, Autophagy-specific gene 8b

(Nagy et al., 2015, Zirin and Perrimon, 2010)

ATG12 PROTEINS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Atg12

Autophagy-related 12

Autophagy-specific gene 12

(Nagy et al., 2015, Zirin and Perrimon, 2010)

NEDD8 PROTEINS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Nedd8

Nedd8 ubiquitin like modifier

(Pirone et al., 2017, Ou et al., 2002)

SUMO PROTEINS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Sumo

Small ubiquitin like modifier

smt3, dSmt3, DmSmt3, l(2)04493

(Pirone et al., 2017, Ureña et al., 2016, Smith et al., 2012, Nie et al., 2009, Shih et al., 2002, Bhaskar et al., 2000)

UBIQUITIN

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG11700

ESTS:199A6T, ESTS:143G11T, Ub, Ubiquitin

(Zhan et al., 2012, Marygold, 2007.1.12)

RpL40

Ribosomal protein L40

(Marygold, 2007.1.12, Izquierdo, 1994)

RpS27A

Ribosomal protein S27A

DUb80, l(2)04820, mfs48, Ubi-m, Ubiquitin

(Marygold, 2007.1.12, Izquierdo, 1994)

Ubi-p5E

Ubiquitin-5E

Ub, ubiquitin, Ubi

(Zhan et al., 2012, Hoe et al., 2011, Marygold, 2007.1.12, Izquierdo, 1994)

Ubi-p63E

Ubiquitin-63E

Ub, ubiquitin, Ubi-p, polyubiquitin, ubi63E

(Lu et al., 2013, Hoe et al., 2011, Marygold, 2007.1.12, Izquierdo, 1994)

UFM1 PROTEINS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Ufm1

Ubiquitin-fold modifier 1

(Yu et al., 2020, Pirone et al., 2017, Duan et al., 2016)

URM1 PROTEINS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Urm1

Ubiquitin-related modifier 1

(Khoshnood et al., 2017, Pirone et al., 2017, Khoshnood et al., 2016)

External Data

Equivalent Group(s)

Other resource(s)

Synonyms and Secondary IDs

Synonym(s)

UBL

UBIQUITIN-LIKE PROTEINS

Secondary FlyBase ID(s)

References (19)

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