Atg8, LC3, Autophagy-specific gene 8a, dAtg8a, Atg-8a
ubiquitin-like protein - regulates autophagy in the midgut and eye - conjugated to phosphatidylethanolamine - this lipid modification anchors Atg8a into the membrane of forming and completed autophagosomes - involved in autophagosome formation, maintaining neuromuscular function and normal lifespan - mediates activation of cap-n-collar resulting in protein homeostasis
Please see the JBrowse view of Dmel\Atg8a for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.55
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.47
Gene model reviewed during 5.56
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Atg8a using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
qRT-PCR of adult female heads assayed at weekly intervals shows that transcript levels decline significantly by 3 weeks and remain supressed.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Atg8a in JBrowse1-32
1-33.7
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: CG32672 BcDNA:LD05816
Source for merge of CG32672 BcDNA:LD05816 was a shared cDNA ( date:030728 ).
"l(1)G0076" may affect "CG32672".
Source for identity of: Atg8a CG32672
