FB2024_02 , released April 23, 2024
Gene: Dmel\Ide
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General Information
Symbol
Dmel\Ide
Species
D. melanogaster
Name
Insulin degrading metalloproteinase
Annotation Symbol
CG5517
Feature Type
protein_coding_gene
FlyBase ID
FBgn0001247
Gene Model Status
Current
Stock Availability
7 publicly available
Gene Summary
Insulin degrading metalloproteinase (Ide) encodes a metalloprotease that controls growth in a cell-autonomous manner by regulating the level of the insulin-like peptide encoded by Ilp2. [Date last reviewed: 2018-09-13] (FlyBase Gene Snapshot)
All Summaries
Also Known As

dIDE

Key Links
Genomic Location
Cytogenetic map
77B6-77B6
Sequence location
Recombination map
3-47
RefSeq locus
NT_037436 REGION:20371672..20375896
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (19 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables metallopeptidase activity
inferred from direct assay
(Kuo et al., 1990, Duckworth et al., 1989, Garcia et al., 1988)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables metal ion binding
inferred from electronic annotation with InterPro:IPR011249
(InterPro Project Members, 2004-)
enables metalloendopeptidase activity
inferred from biological aspect of ancestor with PANTHER:PTN000220551
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR001431
(InterPro Project Members, 2004-)
Biological Process (11 terms)
Terms Based on Experimental Evidence (9 terms)
CV Term
Evidence
References
involved_in defense response to Gram-negative bacterium
inferred from high throughput mutant phenotype
(Cronin et al., 2009)
involved_in determination of adult lifespan
inferred from mutant phenotype
(Hyun and Hashimoto, 2011, Tsuda et al., 2010)
involved_in insulin catabolic process
inferred from direct assay
(Kuo et al., 1990, Duckworth et al., 1989, Garcia et al., 1988)
inferred from mutant phenotype
(Galagovsky et al., 2014)
involved_in negative regulation of developmental growth
inferred from mutant phenotype
(Galagovsky et al., 2014)
involved_in negative regulation of growth
inferred from mutant phenotype
(Tsuda et al., 2010)
involved_in negative regulation of insulin receptor signaling pathway
inferred from genetic interaction with FLYBASE:Pten; FB:FBgn0026379
(Galagovsky et al., 2014)
inferred from genetic interaction with FLYBASE:foxo; FB:FBgn0038197
(Galagovsky et al., 2014)
involved_in positive regulation of innate immune response
inferred from high throughput mutant phenotype
(Cronin et al., 2009)
involved_in proteolysis
inferred from direct assay
(Kuo et al., 1990, Duckworth et al., 1989)
involved_in regulation of egg-laying behavior
inferred from mutant phenotype
(Hyun and Hashimoto, 2011)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in peptide catabolic process
inferred from biological aspect of ancestor with PANTHER:PTN000220551
(GO Reference Genome Project, 2011-)
involved_in proteolysis involved in protein catabolic process
inferred from biological aspect of ancestor with PANTHER:PTN000220551
(GO Reference Genome Project, 2011-)
involved_in proteolysis
inferred from electronic annotation with InterPro:IPR001431
(InterPro Project Members, 2004-)
Cellular Component (5 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Galagovsky et al., 2014)
located_in plasma membrane
inferred from direct assay
(Galagovsky et al., 2014)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
is_active_in cytosol
inferred from biological aspect of ancestor with PANTHER:PTN000220551
(GO Reference Genome Project, 2011-)
is_active_in mitochondrion
inferred from biological aspect of ancestor with PANTHER:PTN000220551
(GO Reference Genome Project, 2011-)
located_in peroxisome
inferred from sequence or structural similarity with HGNC:5381
(Faust et al., 2012)
inferred from sequence model
(Faust et al., 2012)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
Belongs to the peptidase M16 family. (P22817)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Insulin degrading metalloproteinase (Ide) encodes a metalloprotease that controls growth in a cell-autonomous manner by regulating the level of the insulin-like peptide encoded by Ilp2. [Date last reviewed: 2018-09-13]
Pathway (FlyBase)
Negative Regulators of Insulin-like Receptor Signaling Pathway -
Negative regulators of the Insulin-like Receptor signaling pathway suppress Insulin-like receptor (InR) activation or the activity of intracellular effectors. (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989).
Gene Group (FlyBase)
M16 METALLOENDOPEPTIDASES -
M16 metalloendopeptidases belong to MEROPS family M16 and include mitochondrial processing peptidases and peptidases related to bacterial pitrilysin. (Adapted from FBrf0239469.)
Protein Function (UniProtKB)
Can cleave insulin and TGF-alpha.
(UniProt, P22817)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Ide for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry P22817)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.44

Gene model reviewed during 5.39

Gene model reviewed during 5.45

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Ide-RB
FBtr0273273
NM_079458
3439
990
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Ide-PB
FBpp0271781
113.7
990
6.21
P22817
NP_524182
AAF51584
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
MEROPS - An information resource for peptidases (also termed proteases, proteinases and proteolytic enzymes) and the proteins that inhibit them.
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ide using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.72

Transcript Expression
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
organism
(Galagovsky et al., 2014)
third instar larval stage
embryonic/larval fat body | intense
(Galagovsky et al., 2014)
embryonic/larval central nervous system
(Galagovsky et al., 2014)
imaginal disc
(Galagovsky et al., 2014)
embryonic/larval salivary gland
(Galagovsky et al., 2014)
embryonic/larval gut
(Galagovsky et al., 2014)
adult stage | male
organism
(Galagovsky et al., 2014)
adult stage | female
organism
(Galagovsky et al., 2014)
Additional Descriptive Data

Ide transcript is expressed at all developmental stages; expression levels peak in adulthood, and is higher in adult males than females. In third instar larvae, expression is observed in all tissues, and is highest in the fat body.

(Galagovsky et al., 2014)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Galagovsky et al., 2014)
located_in plasma membrane
inferred from direct assay
(Galagovsky et al., 2014)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Ide in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 4 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Ide
Transgenic constructs containing regulatory region of Ide
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(3L)Exel6136
(Ryder, 2004.4.26)
Inferred from location ( 0 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
partially lethal - majority die, with Scer\GAL4Act5C.PI
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4T80
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
fertile
Other Phenotypes
Allele
abnormal developmental rate | nutrition conditional
abnormal feeding behavior | larval stage
abnormal size, with Scer\GAL4ap-md544
abnormal size, with Scer\GAL4en-e16E
abnormal size, with Scer\GAL4sd-SG29.1
abnormal size | adult stage, with Scer\GAL4Bx-MS1096-KE
abnormal size | adult stage, with Scer\GAL4en-e16E
abnormal size | adult stage, with Scer\GAL4ptc-559.1
decreased body size, with Scer\GAL4Act5C.PI
decreased body size, with Scer\GAL4Ilp2.PR
decreased body size | pupal stage
decreased body size | pupal stage, with Scer\GAL4Act5C.PI
decreased cell number, with Scer\GAL4en-e16E
decreased cell number, with Scer\GAL4ptc-559.1
decreased cell size, with Scer\GAL4en-e16E
decreased cell size, with Scer\GAL4ptc-559.1
decreased fecundity | female, with Scer\GAL4Ilp2.PR
increased body size, with Scer\GAL4Act5C.PI
increased body size, with Scer\GAL4Ilp2.PR
increased fecundity | female, with Scer\GAL4Ilp2.PR
long lived
long lived | female limited, with Scer\GAL4Ilp2.PR
short lived, with Scer\GAL4Mef2.PR
short lived | female limited, with Scer\GAL4Ilp2.PR
Phenotype manifest in
Allele
hemolymph, with Scer\GAL4Ilp2.PR
salivary gland, with Scer\GAL4ptc-559.1
wing, with Scer\GAL4ap-md544
wing, with Scer\GAL4Bx-MS1096-KE
wing, with Scer\GAL4en-e16E
wing, with Scer\GAL4ptc-559.1
wing, with Scer\GAL4sd-SG29.1
wing blade posterior compartment, with Scer\GAL4en-e16E
wing disc dorsal compartment, with Scer\GAL4ap-md544
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (6)
Hsap\IDE
14 of 14
Yes
Yes
4  
Hsap\NRDC
6 of 14
No
No
3  
Hsap\PMPCA
1 of 14
No
No
Hsap\PMPCB
1 of 14
No
No
1  
Hsap\UQCRC1
1 of 14
No
No
2  
Hsap\UQCRC2
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (2)
Rnor\Ide
14 of 14
Yes
Yes
Rnor\Nrdc
6 of 14
No
No
Mus musculus (laboratory mouse) (2)
Mmus\Ide
14 of 14
Yes
Yes
Mmus\Nrd1
6 of 14
No
No
Xenopus tropicalis (Western clawed frog) (5)
Xtro\ide
11 of 13
Yes
Yes
Xtro\nrdc
4 of 13
No
No
Xtro\pitrm1
1 of 13
No
No
Xtro\spire2
1 of 13
No
No
Xtro\uqcrc1
1 of 13
No
No
Danio rerio (Zebrafish) (3)
Drer\ide
13 of 14
Yes
Yes
Drer\nrd1b
6 of 14
No
No
Drer\nrd1a
5 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (11)
Cele\C02G6.2
14 of 14
Yes
Yes
Cele\Y70C5C.1
14 of 14
Yes
Yes
Cele\C28F5.4
13 of 14
No
Yes
Cele\F44E7.4
13 of 14
No
Yes
Cele\C02G6.1
2 of 14
No
Yes
Cele\mppa-1
1 of 14
No
No
Cele\mppb-1
1 of 14
No
No
Cele\ucr-1
1 of 14
No
No
Cele\ucr-2.1
1 of 14
No
No
Cele\ucr-2.2
1 of 14
No
No
Cele\ucr-2.3
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (7)
Agam\AgaP_AGAP010351
12 of 12
Yes
Yes
Agam\AgaP_AGAP010315
5 of 12
No
No
Agam\AgaP_AGAP000935
1 of 12
No
No
Agam\AgaP_AGAP001767
1 of 12
No
No
Agam\AgaP_AGAP005558
1 of 12
No
No
Agam\AgaP_AGAP006099
1 of 12
No
No
Agam\AgaP_AGAP008086
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (12)
Atha\AT2G41790
13 of 13
Yes
Yes
Atha\AT3G57470
13 of 13
Yes
Yes
Atha\AT1G06900
7 of 13
No
No
Atha\AT3G57460
5 of 13
No
Yes
Atha\AT5G01440
3 of 13
No
Yes
Atha\AT3G57465
2 of 13
No
Yes
Atha\AT5G56730
2 of 13
No
No
Atha\SPP
2 of 13
No
Yes
Atha\AT1G51980
1 of 13
No
No
Atha\MPPalpha
1 of 13
No
No
Atha\MPPBETA
1 of 13
No
No
Atha\PREP2
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (7)
Scer\STE23
13 of 13
Yes
Yes
Scer\AXL1
2 of 13
No
No
Scer\COR1
1 of 13
No
No
Scer\MAS1
1 of 13
No
No
Scer\MAS2
1 of 13
No
No
Scer\QCR2
1 of 13
No
No
Scer\SDD3
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\mug138
12 of 12
Yes
Yes
Spom\SPAC3H1.02c
1 of 12
No
No
Escherichia coli (enterobacterium) (1)
Ecol\ptrA
10 of 11
Yes
Yes
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Ide. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (6)
CG10588
6 of 13
Nrd1
6 of 13
CG8728
2 of 13
UQCR-C1
2 of 13
CG3107
1 of 13
UQCR-C2
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 3 )
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
IDE; insulin degrading enzyme
14 of 14
146680
       
      NRDC; nardilysin convertase
      6 of 14
      602651
           
          Functional Complementation Data
          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
          Interactions
          Summary of Physical Interactions
          esyN Network Diagram
          Show neighbor-neighbor interactions:
          Show/hide secondary interactors 
          (data from AllianceMine provided by esyN)
          Select Layout:
          Legend:
          Protein
          RNA
          Selected Interactor(s)
          Interactions Browser
          View in Interactions Browser
          Please see the Physical Interaction reports below for full details
          MIST Molecular Interaction Search Tool
          View in MIST tool (external link)
          Please see the Physical Interaction reports below for full details
          protein-protein
          Physical Interaction
          Assay
          References
          Ide - kel
          proximity-dependent biotin identification, Identification by mass spectrometry
          (Mannix et al., 2019)
          RNA-protein
          Physical Interaction
          Assay
          References
          Ide - mbf1
          anti bait coimmunoprecipitation, quantitative reverse transcription pcr
          (Nishioka et al., 2018)
          Summary of Genetic Interactions
          esyN Network Diagram
          Show/hide secondary interactors 
          (data from AllianceMine provided by esyN)
          esyN Network Key:
          Suppression
          Enhancement
          View in Interactions Browser   View in MIST tool (external link)
          Please look at the allele data for full details of the genetic interactions
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Ide
          suppressible
          foxo
          (Galagovsky et al., 2014)
          Ide
          suppressible
          Pten
          (Galagovsky et al., 2014)
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Delta
          enhanceable
          Ide
          (Even et al., 2019)
          Ilp2
          suppressible
          Ide
          (Tsuda et al., 2010)
          lola|psq|Delta
          enhanceable
          Ide
          (Even et al., 2019)
          pbl
          suppressible
          Ide
          (Gregory et al., 2007)
          External Data
          Linkouts
          DroID - A comprehensive database of gene and protein interactions.
          Pathways
          Signaling Pathways (FlyBase)
          Negative Regulators of Insulin-like Receptor Signaling Pathway -
          Negative regulators of the Insulin-like Receptor signaling pathway suppress Insulin-like receptor (InR) activation or the activity of intracellular effectors. (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989).
          Metabolic Pathways
          External Data
          Linkouts
          KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          SignaLink - A signaling pathway resource with multi-layered regulatory networks.
          Genomic Location and Detailed Mapping Data
          Chromosome (arm)
          3L
          Recombination map
          3-47
          Cytogenetic map
          77B6-77B6
          Sequence location
          FlyBase Computed Cytological Location
          Cytogenetic map
          Evidence for location
          77B6-77B6
          Limits computationally determined from genome sequence between P{PZ}eRF100103 and P{EP}trblEP3519
          Experimentally Determined Cytological Location
          Cytogenetic map
          Notes
          References
          Experimentally Determined Recombination Data
          Location

          3-47

          (FlyBase, 2016)

          3-43.6

          (Comeron et al., 2012)
          Left of (cM)
          Right of (cM)
          Notes
          Stocks and Reagents
          Stocks (7)
          Genomic Clones (12)
           

          Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

          cDNA Clones (47)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequenced
          BDGP DGC clones
          Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          Antibody Information
          Laboratory Generated Antibodies
           
          Commercially Available Antibodies
           
          Cell Line Information
          Publicly Available Cell Lines
           
            Other Stable Cell Lines
             
              Other Comments

              Altering Ide expression in insulin-producing cells perturbs organism size, circulating sugar, fecundity and lifespan.

              (Hyun and Hashimoto, 2011)

              Insulin cleavage products generated by Ide enzyme were compared to the cleavage products of rat Ide: both enzymes cleave the A chain of intact insulin at the same sites. Results support the hypothesis that there is evolutionary conservation of Ide and the Ide enzyme plays an important role in cellular function.

              (Duckworth et al., 1989)

              Ide has been isolated and characterized. A high degree of evolutionary conservation is seen with mammalian Ide suggesting an important role of this enzyme in metabolism of insulin.

              (Garcia et al., 1988)
              Relationship to Other Genes
              Source for database merge of
              Additional comments
              Nomenclature History
              Source for database identify of
              Nomenclature comments
              Etymology
              Synonyms and Secondary IDs (11)
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              Study result (0)
              Result
              Result Type
              Title
              External Crossreferences and Linkouts ( 47 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
              Other crossreferences
              AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
              DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
              EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
              FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
              FlyMine - An integrated database for Drosophila genomics
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              MARRVEL_MODEL - MARRVEL (model organism gene)
              MEROPS - An information resource for peptidases (also termed proteases, proteinases and proteolytic enzymes) and the proteins that inhibit them.
              Linkouts
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              SignaLink - A signaling pathway resource with multi-layered regulatory networks.
              References (72)