Please see the JBrowse view of Dmel\sol for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.55
Gene model reviewed during 5.48
Low-frequency RNA-Seq exon junction(s) not annotated.
Alternative translation stop created by use of multiphasic reading frames within coding region.
Gene model reviewed during 5.53
Unconventional translation start (UUG) postulated; FlyBase analysis.
Gene model reviewed during 5.57
5.8, 5.2, 4.6 (northern blot)
None of the polypeptides share 100% sequence identity.
1597 (aa)
1597, 395 (aa); 175 (kD)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\sol using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
JBrowse - Visual display of RNA-Seq signals
View Dmel\sol in JBrowse1-65
1-66.0
Fischbach and Heisenberg (FBrf0037249) and Helfrich (FBrf0044891) quote more distal and more proximal meiotic map positions, respectively.
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
sol- flies have Ca2+-activated protease activity that is indistinguishable from wild-type flies.
sol has been cloned and characterized: brain morphology of mutant individuals has been rescued by P element mediated transformation.
Behavioural and anatomical studies demonstrate that central brain lesions can be interpreted behaviourally.
In behavioral tests, sol1 was complemented by alleles of l(1)19Ff and also by mutations at the nearby slgA, uncl and stn loci (Miklos et al., 1987).
Medulla, lobula and lobula-plate optic ganglia reduced in volume and cell number (anatomical criteria on which several of the mutations, including the most studied allele sol1, were isolated by Heisenberg and Bohl, 1979); lamina seems unaffected; degree of reduction in the three more proximal visual-system ganglia is allele-dependent; after isogenization the severity ranking of nine alleles was as follows: sol2 = sol3 (ca. 50% normal volume) > sol6 = sol9 = sol16 > sol1 = sol4 = sol5 = sol8 (ca. 30% normal volume). Three sol mutants isolated on basis of fast phototaxis; Markow and Merriam (1977) showed that one such allele, sol4, causes flies to be anomalously photo positive and highly geonegative in maze tests. Anatomically, sol mutations cause specific cell types in medulla to be missing (Fischbach and Heisenberg, 1981); stratifications in outer medulla are missing; in general, however, mutant optic lobes are grossly well structured, and there are no disorders in the optic chiasma; special classes of transmedullary columnar neurons as well as intramedullary cells are absent; numbers of columns in the visual ganglia are normal, but numbers of neurons per column are reduced; certain neurons called T1 cells are present in each column in sol1, as usual; these reductions in cell numbers are caused by cell-type-specific degeneration of presumptive optic lobe neurons during pupation, with no degeneration apparent in neuropils of these ganglia (Fischbach and Technau, 1984); the number of axons severely reduced in anterior optic track and the combining of so with sol1 showed that these two mutations act independently on nearly exclusive subsets of these axons (Fischbach and Lyly-Hunerberg, 1983). Mosaic study showed that aberrant morphology of visual ganglia is autonomous in these optic lobes (Fischbach and Technau, 1984); adult eye and lamina optic lobe appear normal. In combination with rol and mnb mutations, sol causes diminished amplitudes of light-on and light-off transient spikes in electroretinogram (Coombe, 1986); visual fixation behavior notably defective (Fischbach and Heisenberg, 1981) <up>e.g., in the walking mode, fixation behavior is actually reversed in all sol alleles (Fischbach)</up> as, to a lesser degree, are landing responses and 'figure/ground' discrimination; on the other hand, optomotor yaw response is nearly normal (Fischbach and Heisenberg, 1981); orientation to spots in multiple Y-maze quite subnormal (Bulthoff, 1982a,b). Shock-avoidance learning of sol1 (Heisenberg, Borst, Wagner and Byers, 1985) and color discrimination in sol1, sol2, and sol3 (Fischbach) are normal; there are, however, deficits in visual plasticity (Gotz, 1983) and in the flexibility that wild types can exhibit in optomotor flight control tests (Gotz, 1985). Circadian rhythms of adult locomotor activity basically normal (Helfrich and Engelmann, 1983; Helfrich, 1986), but when sol1 combined with so, all flies tested showed complex periodicities, with a given behavioral record having one component at approximately 21 and another at approximately 26 h (Helfrich, 1986).
Source for merge of: sol CG1391
