FlyBase Gene Report: Dmel\Gr5a

General Information

Symbol

Dmel\Gr5a

Species

D. melanogaster

Name

Gustatory receptor 5a

Annotation Symbol

CG15779

Feature Type

protein_coding_gene

FlyBase ID

FBgn0003747

Gene Model Status

Current

Stock Availability

8 publicly available

Gene Summary

Gustatory receptor required for response to the sugar trehalose in taste neurons. Gr5a neurons selectively respond to sugars, in contrast to Gr66a cells which respond to bitter compounds. Flies are attracted to sugars and avoid bitter substances, suggesting that Gr5a neuron activity is sufficient to mediate acceptance behavior. Sugar signal transduction occurs through coupling with G-proteins such as Galpha49B and G-salpha60A. (UniProt, Q9W497)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Red Book
Interactive Fly

Also Known As

Tre, han, Gr5A1, trehalose receptor

Key Links

Genomic Location

Cytogenetic map

5A12-5A12

Sequence location

X:5,680,617..5,682,488 [+]

Recombination map

1-12

RefSeq locus

NC_004354 REGION:5680617..5682488

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (12 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables sweet taste receptor activity

inferred from mutant phenotype

(Dahanukar et al., 2007)

enables taste receptor activity

inferred from mutant phenotype

(Ueno et al., 2001)

inferred from mutant phenotype

(Dahanukar et al., 2001)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables ligand-gated monoatomic ion channel activity

inferred from sequence or structural similarity with UniProtKB:Q9V4K2

(Gene Ontology Curators, 2002-)

enables sweet taste receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN000484226

(GO Reference Genome Project, 2011-)

enables taste receptor activity

inferred from electronic annotation with InterPro:IPR009318

(InterPro Project Members, 2004-)

traceable author statement

(Matsunami and Amrein, 2003)

non-traceable author statement

(Dunipace et al., 2001, Clyne et al., 2000)

Biological Process (7 terms)

Terms Based on Experimental Evidence (6 terms)

CV Term

Evidence

References

involved_in detection of chemical stimulus involved in sensory perception of sweet taste

inferred from mutant phenotype

(Ueno et al., 2001)

involved_in detection of chemical stimulus involved in sensory perception of taste

inferred from direct assay

(Chyb et al., 2003)

inferred from mutant phenotype

(Jiao et al., 2008)

involved_in proboscis extension reflex

inferred from mutant phenotype

(Dahanukar et al., 2007)

involved_in response to trehalose

inferred from mutant phenotype

(Ueno et al., 2006)

involved_in sensory perception of sweet taste

inferred from mutant phenotype

(Dahanukar et al., 2007, Ueno et al., 2006)

involved_in sensory perception of taste

inferred from direct assay

(Usui-Aoki et al., 2005)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in detection of chemical stimulus involved in sensory perception of taste

inferred from electronic annotation with InterPro:IPR009318

(InterPro Project Members, 2004-)

involved_in monoatomic ion transmembrane transport

inferred from sequence or structural similarity with UniProtKB:Q9V4K2

(Gene Ontology Curators, 2002-)

involved_in sensory perception of sweet taste

inferred from biological aspect of ancestor with PANTHER:PTN000484226

(GO Reference Genome Project, 2011-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in membrane

non-traceable author statement

(Dunipace et al., 2001, Ueno et al., 2001, Clyne et al., 2000)

inferred from electronic annotation with InterPro:IPR009318

(InterPro Project Members, 2004-)

is_active_in plasma membrane

inferred from sequence or structural similarity with UniProtKB:Q9V4K2

(Gene Ontology Curators, 2002-)

Gene Group (FlyBase)

GUSTATORY RECEPTORS

Protein Family (UniProt)

Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr5a subfamily. (Q9W497)

Protein Signatures (InterPro)

Gustatory receptor

Summaries

Gene Group (FlyBase)

GUSTATORY RECEPTORS -: The Gustatory receptors are a divergent group of (non-GPCR) seven-transmembrane chemoreceptors that are expressed in gustatory sensilla receptor neurons. They detect tastants (non-volatile compounds) via contact chemosensation. (Adapted from FBrf0208984).

Protein Function (UniProtKB)

(UniProt, Q9W497)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

Tre: Trehalose sensitivity (J.C. Hall)

Locus determining differences in sensitivity to the taste of the disaccharide trehalose in behaviorly-based (fluid intake) tests (no differences in sensitivity to glucose, fructose, or sucrose). The Tre+ allele results in high trehalose sensitivity, the Tre allele in low trehalose sensitivity. Females with half the normal dose of a given Tre+ allele are half as sensitive to trehalose, but flies (male or female) with twice the normal dose of Tre+ show only a slight increase in sensitivity as compared to normal flies. Tre is thought to be a structural gene for the trehalose specific receptor in D. melanogaster (Tanimura et al., 1988).

Summary (Interactive Fly)

G-protein coupled receptor - Taste receptor

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Gr5a for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9W497)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.42

Gene model reviewed during 5.50

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Gr5a-RA

FBtr0070802

NM_078495

1490

444

Additional Transcript Data and Comments

Reported size (kB)

1.179 (longest cDNA)

(Ishimoto et al., 2000)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Gr5a-PA

FBpp0070768

51.2

444

9.94

Q9W497

NP_511050

AAF46060

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

392 (aa)

(Ishimoto et al., 2000)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Gustatory receptor

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9W497

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Gr5a using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Gr5a_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

5.20

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

gustatory sensory organ

(Ishimoto et al., 2000)

Additional Descriptive Data

In-situ hybridization to labellum preparations show that Tre1 transcript is present in one of the taste sensory cells beneath a taste bristle.

(Ishimoto et al., 2000)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: P{Gr5a-GAL4.5.156}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

sugar-sensing neuron of taste bristle

(Lin et al., 2013)

Reporter: P{Gr5a-GAL4.8.5}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

sugar-sensing neuron of taste bristle | subset of prothoracic tarsal segment 2

(Ling et al., 2014)

sugar-sensing neuron of taste bristle | subset of prothoracic tarsal segment 3

(Ling et al., 2014)

sugar-sensing neuron of taste bristle | subset of prothoracic tarsal segment 5

(Ling et al., 2014)

sugar-sensing neuron of taste bristle | subset of prothoracic tarsal segment 4

(Ling et al., 2014)

sugar-sensing neuron of taste bristle | subset of mesothoracic tarsal segment 5

(Ling et al., 2014)

sugar-sensing neuron of taste bristle | subset of mesothoracic tarsal segment 4

(Ling et al., 2014)

sugar-sensing neuron of taste bristle | subset of metathoracic tarsal segment 5

(Ling et al., 2014)

sugar-sensing neuron of taste bristle | subset of metathoracic tarsal segment 4

(Ling et al., 2014)

gustatory receptor neuron of proboscis

(Wang et al., 2004)

gustatory receptor neuron of labellum

(Wang et al., 2004)

gnathal ganglion

(Wang et al., 2004)

gustatory receptor neuron of leg

(Wang et al., 2004)

adult ventral nerve cord

(Wang et al., 2004)

gustatory receptor neuron | subset

(Yang et al., 2008)

sugar-sensing neuron of taste bristle of short labellar taste bristle | subset

(Weiss et al., 2011)

sugar-sensing neuron of taste bristle of adult labellum sensillum

(Weiss et al., 2011)

L-type sensillum L1 | intense

(Weiss et al., 2011)

L-type sensillum L2 | intense

(Weiss et al., 2011)

L-type sensillum L4 | intense

(Weiss et al., 2011)

L-type sensillum L6 | intense

(Weiss et al., 2011)

L-type sensillum L8 | intense

(Weiss et al., 2011)

L-type sensillum L9 | intense

(Weiss et al., 2011)

L-type sensillum L3 | intense

(Weiss et al., 2011)

L-type sensillum L5 | intense

(Weiss et al., 2011)

L-type sensillum L7 | intense

(Weiss et al., 2011)

short labellar taste bristle S-a | intense

(Weiss et al., 2011)

bitter-sensitive labellar taste bristle | intense

(Weiss et al., 2011)

short labellar taste bristle S-b | intense

(Weiss et al., 2011)

short labellar taste bristle S-c | intense

(Weiss et al., 2011)

intermediate labellar taste bristle I-a | intense

(Weiss et al., 2011)

intermediate labellar taste bristle | intense

(Weiss et al., 2011)

intermediate labellar taste bristle I-b | intense

(Weiss et al., 2011)

sugar-sensing neuron of taste bristle | subset of adult prothoracic segment

(Clowney et al., 2015)

prothoracic leg taste bristle segmental tarsal chemosensory neuron

(Thoma et al., 2016)

adult abdominal multidendritic neuron | subset

(Park and Kwon, 2011)

Reporter: P{Gr5a-GAL4.T}

Stage

Tissue/Position (including subcellular localization)

Reference

Reporter: P{Gr5a-GAL4.U}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

gustatory receptor neuron of labellar taste bristle | restricted

(Ueno et al., 2006)

gustatory receptor neuron of leg taste bristle | restricted

(Ueno et al., 2006)

Reporter: P{Gr5a-GAL4.Un}

Stage

Tissue/Position (including subcellular localization)

Reference

Reporter: P{Gr5a-GFP.IRES.GFP.IRES.GFP}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

gustatory receptor neuron of labellar taste peg | subset

(Fischler et al., 2007)

gustatory receptor neuron | subset of adult gnathal ganglion

(Fischler et al., 2007)

sugar-sensing neuron of taste bristle

(Cameron et al., 2010)

gustatory receptor neuron | subset of labellar taste bristle

(Cameron et al., 2010)

gustatory receptor neuron of the labellum | subset of posterior maxillary sensory center

(Miyazaki and Ito, 2010)

Reporter: P{Gr5a-LexA-VP16}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

sugar-sensing neuron of taste bristle of labellar taste bristle

(Gordon and Scott, 2009)

prothoracic leg taste bristle segmental tarsal chemosensory neuron

(Thoma et al., 2016)

Reporter: TI{lexA::VP16}Gr5a^LEXA

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

water-sensing neuron of labellar taste bristle of labellar taste bristle

(Fujii et al., 2015)

low salt-sensing neuron of labellar taste bristle of labellar taste bristle

(Fujii et al., 2015)

sugar-sensing neuron of taste bristle of labellar taste bristle

(Fujii et al., 2015)

prothoracic leg taste bristle chemosensory neuron of tarsal segment 4

(Fujii et al., 2015)

prothoracic leg taste bristle chemosensory neuron | subset of tarsal segment 5

(Fujii et al., 2015)

sugar-sensing neuron of taste bristle | subset of prothoracic leg taste bristle chemosensory neuron

(Fujii et al., 2015)

gustatory receptor neuron | subset of pseudotracheal taste peg

(Fujii et al., 2015)

gustatory receptor neuron | subset of labral sense organ neuron

Comment: Expressed in a subset of gustatory receptor neurons

(Fujii et al., 2015)

adult subesophageal zone | restricted

(Fujii et al., 2015)

maxillary palp olfactory receptor neuron | subset

(Fujii et al., 2015)

antennal lobe glomerulus VA7l | restricted

(Fujii et al., 2015)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Gr5a in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Gr5a

View exonic expression by tissue for Dmel\Gr5a

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

44873/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0003747

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0003747

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0003747

Flygut - An atlas of the Drosophila adult midgut

FBgn0003747

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 67 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Gr5a

Transgenic constructs containing regulatory region of Gr5a

Aberrations (Deficiencies and Duplications) ( 7 )

Inferred from experimentation ( 7 )

Gene disrupted in

Df(1)Exel6236

(Ryder, 2004.4.26)

Df(1)Tre^ΔEP1

(Ueno et al., 2001)

Df(1)Tre^ΔEP3

(Ueno et al., 2001)

Df(1)Tre^ΔEP5

(Ueno et al., 2001)

Df(1)Tre^ΔEP13

(Ueno et al., 2001)

Df(1)Tre^ΔEP18

(Ueno et al., 2001)

Gene partially disrupted in

Df(1)Δ22

(Rollmann et al., 2006)

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Scer\GAL4^Mef2.PR

Gr5a^GD716

viable, with Scer\GAL4^pnr-MD237

Gr5a^GD716

Other Phenotypes

Allele

abnormal feeding behavior

abnormal neurophysiology

abnormal neurophysiology | adult stage

Gr5a^ΔEP5

abnormal proboscis extension reflex

abnormal taste perception

abnormal taste perception, with Scer\GAL4^Gr21a.9.323

Gr5a^UAS.cDa

abnormal taste perception, with Scer\GAL4^Gr63a.PF

Gr5a^UAS.cDa

abnormal taste perception | recessive

Gr5a^ΔEP5

abnormal taste perception | semidominant

Gr5a⁰¹

Phenotype manifest in

Allele

labellar taste bristle

Gr5a^ΔEP19

large labellar taste bristle

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (0)

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (0)

Mus musculus (laboratory mouse) (0)

Xenopus tropicalis (Western clawed frog) (0)

Danio rerio (Zebrafish) (0)

Caenorhabditis elegans (Nematode, roundworm) (2)

Cele\gur-3

2 of 14

Yes

Cele\lite-1

2 of 14

Yes

Anopheles gambiae (African malaria mosquito) (9)

Agam\GPRGR15

11 of 12

Yes

4 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

2 of 12

2 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Gr5a. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (7)

11 of 13

9 of 13

7 of 13

7 of 13

6 of 13

6 of 13

5 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

MIST Molecular Interaction Search Tool

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Gr61a|Gr5a

suppressible

Gr64a

(Yavuz et al., 2014)

Gr61a|Gr5a

suppressible

Gr64b|Gr64e

(Yavuz et al., 2014)

Gr61a|Gr5a

suppressible

Gr64e|Gr64a

(Yavuz et al., 2014)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

pbl

enhanceable

Gr5a

(Gregory et al., 2007)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

69345

DroID - A comprehensive database of gene and protein interactions.

FBgn0003747

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-12

Cytogenetic map

5A12-5A12

Sequence location

X:5,680,617..5,682,488 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

5A12-5A12

Limits computationally determined from genome sequence between P{EP}Tre1^EP496 and P{EP}cv^EP1349&P{EP}CG32758^EP1368

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-12

(FlyBase, 2016)

1-14.4

(Comeron et al., 2012)

(Tanimura et al., 1982)

1-13.6

Left of (cM)

(Tanimura et al., 1982)

Right of (cM)

Notes

Closely linked to cx.

(Tanimura et al., 1982)

Stocks and Reagents

Stocks (8)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

31282

y¹ v¹; P{TRiP.JF01223}attP2

31283

y¹ v¹; P{TRiP.JF01224}attP2

93440

w¹¹¹⁸ TI{lexA::VP16}Gr5a^LEXA

57592

w^*; P{Gr5a-GAL4.8.5}6; Dr¹/TM3, Sb¹

57591

w^*; wg^Sp-1/CyO; P{Gr5a-GAL4.8.5}2/TM3, Sb¹

Kyoto

201255

y¹ w^67c23 P{GSV2}Gr5a^GS7438/Binsinscy

VDRC

v110528

P{KK112090}VIE-260B

v12347

w¹¹¹⁸; P{GD716}v12347

Genomic Clones (13)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (5)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0003747

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0003747

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Gr5a encodes a taste receptor required for response to the sugar trehalose, but not for response to sucrose, indicating a role for G protein-mediated signalling in the transduction of sweet taste.

(Dahanukar et al., 2001)

Encodes a gustatory sugar receptor involved in the response to trehalose.

(Ueno et al., 2001)

Genetic evidence suggests Gr5a is the structural gene for the trehalose receptor. Trehalose sensitivity decreases in females carrying half the normal dosage of Gr5a, but does not increase with an increase in Gr5a dosage. Changes in sensitivity of several aneuploid flies suggest there is an upper limit to the number of molecules that can be incorporated into the receptor membrane.

(Tanimura et al., 1988)

Relationship to Other Genes

Source for database merge of

Source for merge of: Tre CG15779

(Isono, 2001.9.22)

Source for merge of: Tre Gr5a

(Ueno et al., 2001)

Additional comments

Although FBrf0128502 reported that Tre1, which maps extremely close to Gr5a, mediates the trehalose response, the balance of evidence suggests that Gr5a, rather than Tre1, encodes a trehalose receptor.

(Dahanukar et al., 2001)

The "CG15779"/"Gr5a" gene corresponds to the "Trehalose-sensitivity" complementation group as opposed to the "CG3171" gene, as was reported in FBrf0128502.

(Isono, 2001.9.22)

Expression of mRNAs in mutant flies, expression analysis in wild-type flies and amino acid polymorphism data suggest that the "Gr5a" and not "CG3171" corresponds to the "Tre" (Trehalose-sensitivity) locus.

(Ueno et al., 2001)

Evidence from FBrf0138267 (expression of mRNAs in mutant flies, expression analysis in wild-type flies and amino acid polymorphism data) suggests that the CG15779 gene prediction (Gr5a) corresponds to the "Trehalose-sensitivity" locus, mutation of which results in low sensitivity to trehalose. The "Trehalose-sensitivity" locus does not correspond to "Tre1" from FBrf0128502 which corresponds to the CG3171 gene prediction (which is adjacent to and divergently transcribed from CG15779). Mutation of Tre1 may also affect the sensitivity of flies to trehalose since mutants affecting Tre1 also show low sensitivity to trehalose which can be rescued by overexpression of Tre1 (FBrf0128502).

(FlyBase, 1992-)

Nomenclature History

Source for database identify of

Nomenclature comments

The symbol used in FlyBase for this gene has been changed from "Tre" (Trehalose-sensitivity) to "Gr5a" (Gustatory receptor 5a) to match the format used for other gustatory receptor genes, and to avoid confusion with the neighbouring "Tre1" (Trapped in endoderm 1) gene.

(FlyBase, 2009-)

Etymology

Synonyms and Secondary IDs (19)

Reported As

Symbol Synonym

CG15779

(Keleman et al., 2009.8.5, Ni et al., 2008, Grieder et al., 2007, Molnar et al., 2006, Marcus, 2003, Dahanukar et al., 2001, Dunipace et al., 2001, Isono, 2001.9.22)

Dmel5a

(Kent and Robertson, 2009)

GR5A

(Cameron et al., 2010)

GR5a

(Pandey et al., 2023, Montell, 2021, Aranha and Vasconcelos, 2018, Scott, 2018, Hoopfer, 2016, Montell, 2009)

GRLU.7

Gr5

(Marella et al., 2006)

Gr5A1

(Scott and Axel, 2001.4.25, Scott et al., 2001)

Gr5a

(Ali et al., 2022, Dweck et al., 2022, Kohatsu et al., 2022, Stanley et al., 2021, Chen and Dahanukar, 2020, Koyama et al., 2020, Miller et al., 2020, Zhao et al., 2020, Chen et al., 2019, Lin et al., 2019, Moreira et al., 2019, Abrat et al., 2018, Abu et al., 2018, Bohra et al., 2018, Kendroud et al., 2018, Kim et al., 2018, Landayan et al., 2018, Ryuda et al., 2018, Hasegawa et al., 2017, McGinnis et al., 2016, French et al., 2015, Fujii et al., 2015, Lau et al., 2015, Shim et al., 2015, Waterson et al., 2015, Yang et al., 2015, Freeman et al., 2014, Liman et al., 2014, Ro et al., 2014, Sun et al., 2014, Yavuz et al., 2014, Dus et al., 2013, Itskov and Ribeiro, 2013, Mishra et al., 2013, Sengupta, 2013, Herrero, 2012, Inagaki et al., 2012, Keene and Masek, 2012, Linford et al., 2012, Bredendiek et al., 2011, Dus et al., 2011, Weiss et al., 2011, Weiss et al., 2011, Wisotsky et al., 2011, Cameron et al., 2010, Chatterjee et al., 2010, Kain et al., 2010, Gardiner et al., 2009, Robertson, 2009, Takahashi et al., 2009, Zhou et al., 2009, Bharucha et al., 2008, Hiroi et al., 2008, Jiao et al., 2008, Moon and Montell, 2008, Thorne and Amrein, 2008, Ueno and Kidokoro, 2008, Colomb and Stocker, 2007, Colomb et al., 2007, Dahanukar et al., 2007, Ebbs and Amrein, 2007, Fischler et al., 2007, Jiao et al., 2007, McBride et al., 2007, Ueno and Kidokoro, 2007, de Bruyne and Warr, 2006, Rollmann et al., 2006, Ueno et al., 2006, van der Goes van Naters and Carlson, 2006, Amrein and Thorne, 2005, Isono et al., 2005, Koseki et al., 2005, Morita et al., 2005, Scott, 2005, Thorne et al., 2005, Usui-Aoki et al., 2005, Dahanukar et al., 2004, Inomata et al., 2004, Stocker, 2004, Thorne et al., 2004, Wang et al., 2004, Chyb et al., 2003, Giarratani and Vosshall, 2003, Kunwar et al., 2003, Matsunami and Amrein, 2003, Robertson et al., 2003, Kim and Carlson, 2002, Dahanukar et al., 2001, Dunipace et al., 2001, Robertson, 2001.11.11, Ueno et al., 2001)

GrLU7

(Scott and Axel, 2001.4.25)

LU.7

(Clyne et al., 2000)

Tre

(Cameron et al., 2010, Zhou et al., 2009, Gregory et al., 2007, Grieder et al., 2007, Molnar et al., 2006, Ramos et al., 2006, Isono et al., 2005, Koseki et al., 2005, Lindsley and Zimm, 1992)

han

(Nagy et al., 2019, Scott, 2005)

tre

(Matsunami and Amrein, 2003)

Name Synonyms

Gr5a

(Scott, 2005)

Gustatory receptor 5a

(Marella et al., 2006)

Gustatory receptor LU.7

(Clyne et al., 2000)

Trehalose sensitivity

(Lindsley and Zimm, 1992)

Trehalose-sensitivity

gustatory receptor 5a

(Rollmann et al., 2006)

trehalose receptor

(Itskov and Ribeiro, 2013, Koseki et al., 2004)

Secondary FlyBase IDs

FBgn0029787
FBgn0041213

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 385 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

44873

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

AB066610
AB066611
AB066612
AB066619
AB066620
AB066621
AB066622
AB066623
AB066624
AB066625
AB066626
AB066627
AB066628
AB066629
AB066630
AB066631
AB066632
AB066633
AB066634
AB066635
AB066636
AB066637
AB066638
AB066639
AB066640
AB066641
AB066642
AB066643
AB162449
AB162450
AB162451
AB162452
AB162453
AB162454
AB162455
AB162456
AB162457
AB162458
AB162459
AB162460
AB162461
AB162462
AB162463
AB162464
AB162465
AB162466
AB162467
AB162468
AB162469
AB162470
AB162471
AB162472
AB162473
AB162474
AB162475
AB162476
AB162477
AB162478
AB162479
AB162480
AB162481
AB162482
AB162483
AB162484
AB162485
AB162486
AB162487
AB162488
AB162489
AB162490
AB162491
AB162492
AB162493
AB162494
AB162495
AB162496
AB162497
AB162498
AB162499
AB162500
AB162501
AB162502
AB162503
AB162504
AB162505
AB162506
AB162507
AB162508
AB162509
AB162510
AB162511
AB162512
AB162513
AB162514
AB162515
AB162516
AB162517
AB162518
AB162519
AB162520
AB162521
AB162522
AB162523
AB162524
AB162525
AB162526
AB162527
AB162528
AB162529
AB162530
AB162531
AB162532
AB162533
AB162534
AB162535
AB162536
AB162537
AB162538
AB162539
AB162540
AB162541
AB162542
AB162543
AB162544
AB162545
AB162546
AB162547
AB162548
AB162549
AB162550
AB162551
AB162552
AB162553
AB162554
AB162555
AB162556
AB162557
AB162558
AB162559
AB162560
AB162561
AB162562
AB162563
AB162564
AB162565
AB162566
AB162567
AB162568
AB162569
AB162570
AB162571
AB162572
AB162573
AB162574
AB162575
AB162576
AB162577
AB162578
AB162579
AB162580
AB162581
AB162582
AB162583
AB162584
AB162585
AB162586
AB162587
AB162588
AB162589
AB162590
AB162591
AB162592
AB162593
AB162594
AB162595
AB162596
AB162597
AB162598
AB162599
AB162600
AX058703

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9W497

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9W497

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9W497

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

44873/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0003747

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0003747

FlyMine - An integrated database for Drosophila genomics

FBgn0003747

InterPro - A database of protein families, domains and functional sites

Gustatory receptor

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG15779

MARRVEL_MODEL - MARRVEL (model organism gene)

44873

Linkouts

BioGRID - A database of protein and genetic interactions.

69345

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0003747

DroID - A comprehensive database of gene and protein interactions.

FBgn0003747

DRSC - Results frm RNAi screens

FBgn0003747

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Gr5a_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0003747

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0003747

Flygut - An atlas of the Drosophila adult midgut

FBgn0003747

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

References (180)

The following external sites may use different assemblies or annotations than FlyBase.

5.20

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