Dh, DH44, CRF-like peptide, Drm-DH, Diuretic hormone
hormone produced by brain neurosecretory cells - sensor of nutritive sugar - directs the detection and consumption of nutritive sugar - controls sperm retention and storage by females - a circadian output hormone that is required for normal rest:activity rhythms
Please see the JBrowse view of Dmel\Dh44 for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.40
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.53
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Dh44 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Dh44 is expressed in large numbers of cells distributed across the brain and thoracico-abdominal ganglion.
Expression of Dh44 was established via single cell RNA sequencing of ScerGAL4Kurs58 or ScerGAL4c767 positive adult pars intercerebralis neurons.
Dh44 is expressed in the embryo in the midline in VUM interneuron 3 (called iVUM6 in the paper) of segments A2-A5 and in one cell in the labial segment.
Anti-Dh44 labels adult DH44 neurons of pars intercerebralis, these neurons were co-labelled with anti-Lkr or ScerGAL4GMR65C11 in separate experiments.
Expression of Dh44 protein is restricted to six ScerGAL4Kurs58 positive neurons of the adult pars intercerebralis.
Comment: 48 hours APF
Comment: 48 hours APF
JBrowse - Visual display of RNA-Seq signals
View Dmel\Dh44 in JBrowse3-49
3-46.2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Dh44 Dh
'Dh' (FBgn0012344) renamed to 'Dh44' to reflect usage in the literature, to clearly distinguish it from 'Dh31' (FBgn0032048) and 'dh' (FBgn0014147), and for consistency with the nomenclature of 'Dh44-R1' (FBgn0033932) and the other diuretic hormone and diuretic hormone receptor genes.
