FlyBase Gene Report: Dmel\Idgf3

General Information

Symbol

Dmel\Idgf3

Species

D. melanogaster

Name

Imaginal disc growth factor 3

Annotation Symbol

CG4559

Feature Type

protein_coding_gene

FlyBase ID

FBgn0020414

Gene Model Status

Current

Stock Availability

16 publicly available

Gene Summary

Imaginal disc growth factor 3 (Idgf3) encodes a member of the chitinase-like protein family that was originally shown to facilitate insulin signalling in imaginal disc cell lines. Idgf3 product is a component of hemolymph clot, aids in wound healing and protects against certain infections. [Date last reviewed: 2018-10-04] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

lincRNA.163, IDGF, DmIDGF3, BG:DS02780.2

Key Links

Genomic Location

Cytogenetic map

36A1-36A1

Sequence location

2L:16,450,907..16,455,194 [+]

Recombination map

2-52

RefSeq locus

NT_033779 REGION:16450907..16455194

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (9 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables imaginal disc growth factor receptor binding

inferred from direct assay

(Kawamura et al., 1999)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables chitin binding

inferred from electronic annotation with InterPro:IPR011583

(InterPro Project Members, 2004-)

Biological Process (6 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

involved_in chitin-based cuticle development

inferred from mutant phenotype

(Pesch et al., 2016)

involved_in ecdysis, chitin-based cuticle

inferred from mutant phenotype

(Pesch et al., 2016)

involved_in imaginal disc development

inferred from direct assay

(Kawamura et al., 1999)

involved_in wound healing

inferred from mutant phenotype

(Pesch et al., 2016)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in carbohydrate metabolic process

inferred from electronic annotation with InterPro:IPR001223

(InterPro Project Members, 2004-)

involved_in chitin catabolic process

inferred from biological aspect of ancestor with PANTHER:PTN000126545

(GO Reference Genome Project, 2011-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in extracellular region

inferred from high throughput direct assay

(Karlsson et al., 2004)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in extracellular region

inferred from biological aspect of ancestor with PANTHER:PTN000126545

(GO Reference Genome Project, 2011-)

located_in extracellular region

non-traceable author statement

(Kawamura et al., 1999)

Gene Group (FlyBase)

IMAGINAL DISC GROWTH FACTORS

Protein Family (UniProt)

Belongs to the glycosyl hydrolase 18 family. IDGF subfamily. (Q8MLZ7)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

IMAGINAL DISC GROWTH FACTORS -: The Imaginal Disc Growth Factors (IDGF) belong to the 18-glycosylhydrolase family. IDGFs possess a single glyco18 domain which is catalytically inactive and may act as a chitin binding module. (Adapted from FBrf0231276 and FBrf0230884).

Protein Function (UniProtKB)

Cooperates with insulin-like peptides to stimulate the proliferation, polarization and motility of imaginal disk cells. May act by stabilizing the binding of insulin-like peptides to its receptor through a simultaneous interaction with both molecules to form a multiprotein signaling complex.

(UniProt, Q8MLZ7)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Idgf3 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q8MLZ7)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.50

Gene model reviewed during 5.51

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Idgf3-RA

FBtr0080864

NM_057908

1649

441

Idgf3-RB

FBtr0080863

NM_165157

3145

441

Idgf3-RC

FBtr0080862

NM_165158

1724

441

Idgf3-RD

FBtr0342945

NM_001299053

3801

441

Additional Transcript Data and Comments

Reported size (kB)

1.683 (longest cDNA)

(Kawamura et al., 1999)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Idgf3-PA

FBpp0080421

49.3

441

7.62

FBpp0080420

49.3

441

7.62

FBpp0080419

49.3

441

7.62

FBpp0309719

49.3

441

7.62

X2JA18

NP_001285982

AHN54496

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

441 aa isoforms: Idgf3-PA, Idgf3-PB, Idgf3-PC, Idgf3-PD

Additional Polypeptide Data and Comments

Reported size (kDa)

441 (aa)

(Kawamura et al., 1999)

Comments

External Data

Post Translational Modification

Glycosylated.

(UniProt, Q8MLZ7)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Idgf3 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

3.57

Transcript Expression

No Assay Recorded

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

ventral furrow | vicinity of

(Kawamura et al., 1999)

amnioproctodeal invagination | vicinity of

(Kawamura et al., 1999)

embryonic stage & larval stage

embryonic/larval salivary gland

(Kawamura et al., 1999)

third instar larval stage

embryonic/larval brain

(Kawamura et al., 1999)

ring gland

(Kawamura et al., 1999)

imaginal disc

(Kawamura et al., 1999)

adult stage & oogenesis

oocyte

(Kawamura et al., 1999)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

cephalic furrow | vicinity of

(Kawamura et al., 1999)

embryonic/larval tracheal system

(Kawamura et al., 1999)

yolk

(Kawamura et al., 1999)

embryonic stage & larval stage

embryonic/larval fat body

(Kawamura et al., 1999)

embryonic stage 11 -- 12

yolk nucleus

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic/larval fat body

(Fisher et al., 2012)

yolk nucleus

(Fisher et al., 2012)

third instar larval stage

embryonic/larval optic lobe

(Kawamura et al., 1999)

embryonic/larval lymph gland

(Kawamura et al., 1999)

adult stage & oogenesis

nurse cell

(Kawamura et al., 1999)

Additional Descriptive Data

Idgf3 transcripts are expressed at all stages tested on northern blots but most heavily in mid-larval stages. Idgf3 transcripts are present in the yolk cytoplasm in the early embryo but are excluded from the blastoderm as it cellularizes. During gastrulation, transcripts are observed in rows parallel to the major invaginations including the ventral furrow, the cephalic furrow, and the anterior and posterior midgut invaginations. In late embryos, Idgf3 transcripts are observed in yolk cells, fat body, salivary glands, and in the tracheal system. In third instar larvae, Idgf3 transcripts are strongly expressed in fat body, the ring gland, and in lymph glands. Expression is also observed in the optic lobes, the central brain, and in imaginal discs. Duing oogenesis, Idgf3 transcripts are present in nurse cells and in the oocyte. While the patterns of expression of the four Idgf genes are in general very similar, they are differentially expressed in the larval salivary glands. Levels of Idgf2 and Idgf4 are generally higher than Idgf1 and Idgf3.

(Kawamura et al., 1999)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

hemocyte

(Kucerova et al., 2016)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

At a wound site, Idgf3 staining identifes both hemocytes and clot fibers.

(Kucerova et al., 2016)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in extracellular region

inferred from high throughput direct assay

(Karlsson et al., 2004)

Expression Deduced from Reporters

Reporter: P{Idgf3-GFP}

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

hemocyte

(Kucerova et al., 2016)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Idgf3 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Idgf3

View exonic expression by tissue for Dmel\Idgf3

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0020414

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34981/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0020414

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0020414

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0020414

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4559

Flygut - An atlas of the Drosophila adult midgut

FBgn0020414

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Idgf3

Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 27 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Idgf3

Transgenic constructs containing regulatory region of Idgf3

Aberrations (Deficiencies and Duplications) ( 3 )

Inferred from experimentation ( 3 )

Gene disrupted in

Df(2L)ED1102

(Sustar et al., 2023)

Df(2L)Exel7065

(Ryder, 2004.4.26)

Df(2L)Idgf2-3^Δ

(Sustar et al., 2023)

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal, with Scer\GAL4^69B

Idgf3^GD5407

partially lethal - majority live, with Scer\GAL4^btl.PS

Idgf3^GD5407

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Idgf3^GD5407

viable, with Scer\GAL4^Mef2.PR

Idgf3^GD5407

viable, with Scer\GAL4^pnr-MD237

Idgf3^GD5407

Other Phenotypes

Allele

abnormal wound healing, with Scer\GAL4^69B

Idgf3^GD5407

increased size | embryonic stage, with Scer\GAL4^btl.PS

Idgf3^GD5407

some die during larval stage, with Scer\GAL4^69B

Idgf3^GD5407

Phenotype manifest in

Allele

embryonic/larval cuticle, with Scer\GAL4^69B

Idgf3^GD5407

embryonic/larval tracheal dorsal trunk | embryonic stage, with Scer\GAL4^btl.PS

Idgf3^GD5407

taenidial fold | larval stage, with Scer\GAL4^btl.PS

Idgf3^GD5407

tracheal lumen | embryonic stage, with Scer\GAL4^btl.PS

Idgf3^GD5407

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (6)

Hsap\CHI3L1

5 of 14

Yes

Hsap\CHIT1

5 of 14

Yes

4 of 14

4 of 14

4 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (6)

Rnor\Chi3l1

4 of 14

Yes

Rnor\Chit1

4 of 14

Yes

Rnor\RGD1309110

4 of 14

Yes

Rnor\Chi3l3

3 of 14

Rnor\Chia

3 of 14

Rnor\Ctbs

1 of 14

Mus musculus (laboratory mouse) (9)

Mmus\Chil1

5 of 14

Yes

Mmus\Chit1

5 of 14

Yes

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

3 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (5)

Xtro\chit1

3 of 13

Yes

2 of 13

1 of 13

1 of 13

1 of 13

Yes

Danio rerio (Zebrafish) (8)

Drer\chia.3

5 of 14

Yes

Drer\chia.6

5 of 14

Yes

4 of 14

4 of 14

4 of 14

3 of 14

2 of 14

Drer\si:ch211-226m16.2

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (39)

Cele\chil-3

4 of 14

Yes

Cele\chil-4

4 of 14

Yes

Cele\chil-6

4 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

Yes

Cele\btb-17

1 of 14

Yes

Cele\btb-18

1 of 14

Yes

Cele\C45E5.3

1 of 14

Yes

Cele\K08F9.3

1 of 14

Anopheles gambiae (African malaria mosquito) (29)

Agam\AgaP_AGAP008060

5 of 12

Yes

4 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

2 of 12

2 of 12

2 of 12

2 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (9)

Atha\AT4G19720

4 of 13

Yes

Atha\AT4G19730

4 of 13

Yes

Atha\AT4G19750

4 of 13

Yes

Atha\AT4G19760

4 of 13

Yes

Atha\AT4G19800

4 of 13

Yes

Atha\AT4G19820

4 of 13

Yes

Atha\ChiC

4 of 13

Yes

Atha\AT4G19770

3 of 13

Atha\AT4G19740

2 of 13

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\CTS2

2 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Idgf3. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (20)

6 of 13

6 of 13

6 of 13

6 of 13

6 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

3 of 13

3 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

CHI3L1; chitinase 3 like 1

model of schizophrenia

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CHI3L1; chitinase 3 like 1

5 of 14

601525

schizophrenia

CHIT1; chitinase 1

5 of 14

600031

CHITOTRIOSIDASE DEFICIENCY; CHITD

CHI3L2; chitinase 3 like 2

4 of 14

601526

CHIA; chitinase acidic

4 of 14

606080

OVGP1; oviductal glycoprotein 1

4 of 14

603578

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

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Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

RNA-RNA

Physical Interaction

Assay

References

Idgf3 - mir-8

quantitative reverse transcription pcr

(Lee et al., 2015)

Summary of Genetic Interactions

esyN Network Diagram

Other Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0020414

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Neutrophil degranulation

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-52

Cytogenetic map

36A1-36A1

Sequence location

2L:16,450,907..16,455,194 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

36A1-36A1

Limits computationally determined from genome sequence between P{EP}fzy^EP1028&P{lacW}mRpL4^k14608 and P{PZ}dac^P

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

36A2-36A4

(Kawamura, 1998.10.28, Kawamura et al., 1997)

Experimentally Determined Recombination Data

Location

2-52

(FlyBase, 2016)

2-50.1

(Comeron et al., 2012)

(Kawamura et al., 1997)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (16)

Genomic Clones (13)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (99)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GH07453

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0020414

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0020414

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Kucerova et al., 2016)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Gene expression is increased in response to the presence of either one or two copies of Scer\GAL4^hs.PB.

(Liu and Lehmann, 2008)

Maps to subclone 3-d7 of P1 DS02780.

(Kawamura et al., 1999)

Candidate gene for tibia length quantitative trait locus.

(Macdonald and Goldstein, 1999)

Encodes a soluble growth factor that works in combination with insulin to stimulate cell proliferation, cell polarisation and movement.

(Kawamura et al., 1997)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Idgf3 CG4559

(Zhong, 1999.11)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

BG:DS02780.2

(Ashburner et al., 1999, Ashburner et al., 1999.10.12)

CG4559

(National Institute of Genetics Fly Stocks, 2022-, Bourouis, 2013.11.8, Ibrahim et al., 2013, Lombard et al., 2013, Mosallanejad et al., 2010, Perkins et al., 2009, Karlsson et al., 2004, Zhu et al., 2004, De Gregorio et al., 2001, Irving et al., 2001)

DmIDGF3

(Zhang et al., 2011, Zhu et al., 2008)

IDGF

(Edgar, 2006, Britton et al., 1999)

IDGF-3

(Varela et al., 2002)

IDGF3

(Lee et al., 2015, Kucerova and Zurovec, 2007, Pappu et al., 2005, Monserrate et al., 2003, Monserrate et al., 2003, Hipfner and Cohen, 1999, Kawamura, 1998.10.28)

idgf3

(Behr and Riedel, 2020, Towler et al., 2020, Pesch et al., 2016, Moorman et al., 2006, Reese et al., 2000, Reese et al., 2000)

lincRNA.163

(FlyBase Genome Annotators, 2014, Young et al., 2012)

Name Synonyms

Imaginal disc growth factor 3

(Garlovsky et al., 2022, Ibrahim et al., 2013, Kawamura et al., 1997)

imaginal disc growth factor 3

(Kucerova et al., 2016, Chintapalli et al., 2012)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 95 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

34981

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q8MLZ7

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q8MLZ7

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

X2JA18

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q8MLZ7

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0020414

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34981/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0020414

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0020414

FlyMine - An integrated database for Drosophila genomics

FBgn0020414

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG4559

MARRVEL_MODEL - MARRVEL (model organism gene)

34981

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0020414

DroID - A comprehensive database of gene and protein interactions.

FBgn0020414

DRSC - Results frm RNAi screens

FBgn0020414

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0020414

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0020414

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4559

Flygut - An atlas of the Drosophila adult midgut

FBgn0020414

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0020414

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Neutrophil degranulation

References (111)

The following external sites may use different assemblies or annotations than FlyBase.

3.57

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