FB2024_02 , released April 23, 2024
Gene: Hsap\PTEN
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General Information
Symbol
Hsap\PTEN
Species
H. sapiens
Name
phosphatase and tensin homolog
Annotation Symbol
Feature Type
engineered_foreign_gene
FlyBase ID
FBgn0028728
Gene Model Status
Not Applicable
Stock Availability
1 publicly available
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

PTEN

Key Links
Foreign Gene Data

Foreign sequence; species == Homo sapiens; gene == PTEN; HGNC:9588.

(FlyBase Curators, 1992-)
Function

Information on product gene function for non-D. melanogaster species is no longer provided by FlyBase.

Up-to-date information on gene product function can be found by searching UniProtKB for proteins or RNAcentral for non-coding RNAs.

Summaries
Gene Model and Products
Number of Transcripts
0
Number of Unique Polypeptides
0
Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Experimentally Determined Structures
Crossreferences
Comments on Gene Model
Sequence Ontology: Class of Gene
engineered_foreign_gene
Transcript Data
Annotated Transcripts
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Polypeptides with Identical Sequences

 

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
    Mapped Features

    Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Hsap\PTEN using the Feature Mapper tool.

    External Data
    Crossreferences
    Linkouts
    Expression Data
    Testis-specificity index

    The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

    NA

    Transcript Expression
    Additional Descriptive Data
    Marker for
     
    Subcellular Localization
    CV Term
    Polypeptide Expression
    Additional Descriptive Data
    Marker for
     
    Subcellular Localization
    CV Term
    Evidence
    References
    Expression Deduced from Reporters
    High-Throughput Expression Data
    Associated Tools

    JBrowse - Visual display of RNA-Seq signals

    View Hsap\PTEN in JBrowse
    RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
    Bulk Downloads
    RNA-Seq RPKM values for all genes
    Reference
    See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
    Developmental Proteome: Life Cycle
    Developmental Proteome: Embryogenesis
    External Data and Images
    Alleles, Insertions, Transgenic Constructs, and Aberrations
    Classical and Insertion Alleles ( 0 )
    For All Classical and Insertion Alleles Show
     
    Other relevant insertions
    Transgenic Constructs ( 103 )
    For All Alleles Carried on Transgenic Constructs Show
    Transgenic constructs containing/affecting coding region of Hsap\PTEN
    Transgenic constructs containing regulatory region of Hsap\PTEN
    Aberrations (Deficiencies and Duplications) ( 0 )
    Inferred from experimentation ( 0 )
    Inferred from location ( 0 )
      Variants
      Variant Molecular Consequences
      Alleles Representing Disease-Implicated Variants
      Phenotypes
      Orthologs
      Downloads
      Download All DIOPT Orthologs
      Human Orthologs (via DIOPT v9.1)
      Species\Gene Symbol
      Score
      Best Score
      Best Reverse Score
      Source
      Compara
      Domainoid
      eggNOG
      Hieranoid
      Homologene
      Inparanoid
      OMA
      OrthoDB
      OrthoFinder
      OrthoInspector
      orthoMCL
      Panther
      Phylome
      SonicParanoid
      Alignment
      Complementation?
      Transgene?
      Homo sapiens (Human) (0)
      Model Organism Orthologs (via DIOPT v9.1)
      Species\Gene Symbol
      Score
      Best Score
      Best Reverse Score
      Source
      Compara
      Domainoid
      eggNOG
      Hieranoid
      Homologene
      Inparanoid
      OMA
      OrthoDB
      OrthoFinder
      OrthoInspector
      orthoMCL
      Panther
      Phylome
      SonicParanoid
      Alignment
      Complementation?
      Transgene?
      Drosophila melanogaster (Fruit fly) (6)
      Pten
      13 of 14
      Yes
      Yes
       
      0  
      aux
      2 of 14
      No
      No
      0  
      Cdc14
      1 of 14
      No
      No
      0  
      Lar
      1 of 14
      No
      No
      0  
      mRNA-cap
      1 of 14
      No
      No
      0  
      PRL-1
      1 of 14
      No
      No
      0  
      Other Organism Orthologs (via OrthoDB)
      Data provided directly from OrthoDB:Hsap\PTEN. Refer to their site for version information.
      Human Disease Associations
      FlyBase Human Disease Model Reports
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Allele
      Disease
      Evidence
      References
      Potential Models Based on Orthology ( 0 )
      Human Ortholog
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 16 )
      Allele
      Disease
      Interaction
      References
      Hsap\PTENC124S.UAS
      exacerbates  Alzheimer's disease 1
      modeled by Hsap\APPAβ42.UAS.Tag:SS(rPENK)
      (Chiang et al., 2010)
      Hsap\PTENUAS.cHa
      ameliorates  fragile X syndrome
      modeled by Fmr13
      (Monyak et al., 2017)
      Hsap\PTEND107V.UAS
      ameliorates  cancer
      modeled by Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS)
      (Ganguly et al., 2021)
      Hsap\PTENF241S.UAS
      ameliorates  cancer
      modeled by Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS)
      (Ganguly et al., 2021)
      Hsap\PTENY27C.UAS
      ameliorates  cancer
      modeled by Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS)
      (Ganguly et al., 2021)
      Hsap\PTENH93R.UAS
      ameliorates  cancer
      modeled by Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS)
      (Ganguly et al., 2021)
      Hsap\PTENP246L.UAS
      ameliorates  cancer
      modeled by Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS)
      (Ganguly et al., 2021)
      Hsap\PTENR130Q.UAS
      ameliorates  cancer
      modeled by Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS)
      (Ganguly et al., 2021)
      Hsap\PTENC124R.UAS
      ameliorates  cancer
      modeled by Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS)
      (Ganguly et al., 2021)
      Hsap\PTENT131I.UAS
      ameliorates  cancer
      modeled by Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS)
      (Ganguly et al., 2021)
      Hsap\PTENT167N.UAS
      ameliorates  cancer
      modeled by Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS)
      (Ganguly et al., 2021)
      Hsap\PTENG129E.UAS
      ameliorates  cancer
      modeled by Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS)
      (Ganguly et al., 2021)
      Hsap\PTENY138L.UAS
      ameliorates  cancer
      modeled by Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS)
      (Ganguly et al., 2021)
      Hsap\PTENUAS.cPa
      ameliorates  cancer
      modeled by Pten117, Pten2L100
      (Ganguly et al., 2021)
      modeled by Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS)
      (Ganguly et al., 2021)
      Hsap\PTEN4A.UAS
      exacerbates  cancer
      modeled by Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS)
      (Ganguly et al., 2021)
      Hsap\PTENM35V.UAS
      ameliorates  cancer
      modeled by Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS)
      (Ganguly et al., 2021)
      Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
      Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
      Homo sapiens (Human)
      Gene name
      Score
      OMIM
      OMIM Phenotype
      DO term
      Complementation?
      Transgene?
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Dmel gene
      Ortholog showing functional complementation
      Supporting References
      Pten
      Hsap\PTEN
      (Ganguly et al., 2021)
      Interactions
      Summary of Physical Interactions
      esyN Network Diagram
      Interactions Browser
      Summary of Genetic Interactions
      esyN Network Diagram
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      External Data
      Linkouts
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      External Data
      Linkouts
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      Recombination map
      Cytogenetic map
      Sequence location
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      Experimentally Determined Recombination Data
      Location
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (1)
      Genomic Clones (0)
       
        cDNA Clones (0)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
          Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
                Other clones
                  RNAi and Array Information
                  Linkouts
                  Antibody Information
                  Laboratory Generated Antibodies
                   
                  Commercially Available Antibodies
                   
                  Cell Line Information
                  Publicly Available Cell Lines
                   
                    Other Stable Cell Lines
                     
                      Other Comments

                      Phenotypes caused by overexpression of Hsap\PTEN and Pten are indistinguishable.

                      (Huang et al., 1999)
                      Relationship to Other Genes
                      Source for database merge of
                      Additional comments

                      FlyBase curator comment: Name changed to reflect current HGNC name (19th Nov. 2012).

                      (FlyBase Curators, 1992-)
                      Nomenclature History
                      Source for database identify of
                      Nomenclature comments
                      Etymology
                      Synonyms and Secondary IDs (12)
                      Reported As
                      Symbol Synonym
                      BZS
                      (HGNC Curators and FlyBase Curators, 2013-)
                      Hsap\PTEN
                      MHAM
                      (HGNC Curators and FlyBase Curators, 2013-)
                      MMAC1
                      (HGNC Curators and FlyBase Curators, 2013-)
                      PTEN
                      (Monyak et al., 2017, HGNC Curators and FlyBase Curators, 2013-)
                      PTEN1
                      (HGNC Curators and FlyBase Curators, 2013-)
                      TEP1
                      (HGNC Curators and FlyBase Curators, 2013-)
                      hPTEN
                      (Song et al., 2007)
                      Name Synonyms
                      Phosphatase and tensin homolog
                      Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
                      (HGNC Curators and FlyBase Curators, 2013-)
                      mutated in multiple advanced cancers 1
                      (HGNC Curators and FlyBase Curators, 2013-)
                      phosphatase and tensin homolog
                      (HGNC Curators and FlyBase Curators, 2013-)
                      Secondary FlyBase IDs
                        Datasets (0)
                        Study focus (0)
                        Experimental Role
                        Project
                        Project Type
                        Title
                        Study result (0)
                        Result
                        Result Type
                        Title
                        External Crossreferences and Linkouts ( 10 )
                        Sequence Crossreferences
                        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                        Other crossreferences
                        Ensembl_Homo_sapiens -
                        HUGO Gene Nomenclature Committee -
                        MARRVEL - MARRVEL (human gene)
                        Online Mendelian Inheritance in Man (OMIM) -
                        Online Mendelian Inheritance in Man (OMIM) -
                        References (12)