BG:DS07473.3 , PRL
Please see the JBrowse view of Dmel\PRL-1 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.45
Gene model reviewed during 6.13
Homotrimer (By similarity). Interacts with uex, possibly at the plasma membrane (PubMed:31404830).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\PRL-1 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: stronger staining in differentiating retinal cells
Prior to cellularization, PRL-1 is evenly expressed throughout the syncytium. Following cellularization, PRL-1 levels are relatively low in the newly formed blastoderm, but can be seen in the cytoplasm. As embryogenesis proceeds, PRL-1 remains ubiquitously and cytoplasmically expressed, though most abundant in the amnioserosa in later stages of embryogenesis. Analysis of the first through third larval instar tissues showed that PRL-1 becomes localized to and more abundant at the plasma membrane though cytoplasmic staining is still detected. The larval midgut demonstrated the most dynamic expression, with some cells showing predominant PRL-1 staining at plasma membrane and others showing very high levels of PRL-1 in the cytoplasm. PRL-1 appears to be ubiquitously expressed throughout larval development although with variable levels; the gastric caecum consistently demonstrated very strong staining for PRL-1, while the larval brain was consistently among the lowest. In the developing eye and wing discs, PRL-1 is most abundant at the plasma membrane. Staining in the developing eye demonstrates that PRL-1 levels and localization are similar in both actively dividing cells (anterior to the morphogenetic furrow) and differentiated cells (posterior to the morphogenetic furrow).
JBrowse - Visual display of RNA-Seq signals
View Dmel\PRL-1 in JBrowse2-52
2-49.3
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Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Data suggests that PRL-1 is not a vital gene.
Source for merge of: PRL-1 BcDNA:RE40268
One or more of the processed transcripts for these genes contain several non-overlapping open reading frames (ORFs). The non-overlapping ORFs are represented by CG46309 (FBgn0284225) and CG4993 (FBgn0024734).
Source for merge of PRL-1 BcDNA:RE40268 was a shared cDNA ( date:030728 ).
Source for identity of: PRL-1 CG4993