a secreted Ly domain adhesion protein required for septate junction formation and blood-brain barrier integrity - expressed in subperineurial glial cells - attached to the surface membrane via a glycosylphosphatidylinositol anchor - mediates cell adhesive properties - expressed in trachea
Please see the JBrowse view of Dmel\cold for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.42
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
GPI-anchored.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\cold using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
cold transcript is detected in ectodermally-derived tissues, and at late embryonic stages, in cells associated with nerve tracts.
JBrowse - Visual display of RNA-Seq signals
View Dmel\cold in JBrowse2-1.5
2-0.2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: cold CG2813
The gene is named "coiled", reflecting the mutant tracheal phenotype.