Anakonda, aka
transmembrane receptor protein - interacts extracellularly to mediate assembly of tricellular junctions - septate junctions - ectodermal and endodermal epithelia
Please see the JBrowse view of Dmel\bark for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.55
Gene model reviewed during 5.47
N-glycosylated.
May be proteolytically cleaved in the extracellular domain.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\bark using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
bark transcript expression is restricted to ectodermally-derived tissues including tracheal system, foregut, hindgut, salivary gland and epidermis.
bark accumulates at epithelial tricellular junctions.
JBrowse - Visual display of RNA-Seq signals
View Dmel\bark in JBrowse2-11
2-9.7
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
bark is required for septate junction maturation in developing epithelial cells.
Source for identity of: bark CG3921
Named 'anakonda' (aka) based on the tortuous tube phenotype of mutants.
The gene is named "bark beetle" since the convoluted tracheal branches seen in mutant larvae resemble the tracks of bark beetle larvae.