FlyBase Gene Report: Dmel\Grip71

General Information

Symbol

Dmel\Grip71

Species

D. melanogaster

Name

Grip71

Annotation Symbol

CG10346

Feature Type

protein_coding_gene

FlyBase ID

FBgn0032705

Gene Model Status

Current

Stock Availability

7 publicly available

Gene Summary

Grip71 (Grip71) encodes a recruitment adapter protein for multi-protein gamma-tubulin ring complexes (γTuRCs), which template microtubule nucleation. It associates with γTuRCs, but is not required for their assembly. Grip71 is required, however, for γTuRC localisation to spindle microtubules and to centrosomes once other recruitment pathways have been removed. [Date last reviewed: 2023-11-16] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

Dgrip71, Dgp71WD

Key Links

Genomic Location

Cytogenetic map

37A1-37A1

Sequence location

2L:18,708,846..18,711,297 [+]

Recombination map

2-54

RefSeq locus

NT_033779 REGION:18708846..18711297

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (19 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables gamma-tubulin binding

inferred from direct assay

(Gunawardane et al., 2003)

enables protein-macromolecule adaptor activity

inferred from physical interaction with FLYBASE:dgt5; FB:FBgn0033740,FLYBASE:dgt3; FB:FBgn0034569

(Chen et al., 2017)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables gamma-tubulin binding

inferred from biological aspect of ancestor with PANTHER:PTN001871829

(GO Reference Genome Project, 2011-)

Biological Process (8 terms)

Terms Based on Experimental Evidence (8 terms)

CV Term

Evidence

References

involved_in centrosome cycle

inferred from mutant phenotype

(Dobbelaere et al., 2008)

involved_in microtubule nucleation

inferred from direct assay

(Romé and Ohkura, 2018)

involved_in mitotic cell cycle

inferred from high throughput mutant phenotype

(Ducat et al., 2008)

inferred from mutant phenotype

(Verollet et al., 2006)

involved_in mitotic spindle-templated microtubule nucleation

inferred from direct assay

(Chen et al., 2017)

involved_in regulation of cell cycle

inferred from mutant phenotype

(Muller et al., 2006)

involved_in spindle assembly involved in female meiosis I

inferred from mutant phenotype

(Reschen et al., 2012)

involved_in spindle assembly involved in female meiosis

inferred from genetic interaction with FLYBASE:sub; FB:FBgn0003545

(Romé and Ohkura, 2018)

NOT involved_in bicoid mRNA localization

inferred from mutant phenotype

(Reschen et al., 2012)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in microtubule nucleation

inferred from biological aspect of ancestor with PANTHER:PTN001871829

(GO Reference Genome Project, 2011-)

involved_in mitotic cell cycle

inferred from biological aspect of ancestor with PANTHER:PTN001871829

(GO Reference Genome Project, 2011-)

Cellular Component (9 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Dobbelaere et al., 2008)

part_of gamma-tubulin complex

inferred from direct assay

(Romé and Ohkura, 2018)

part_of gamma-tubulin ring complex

inferred from direct assay

(Gunawardane et al., 2003)

located_in meiotic spindle midzone

inferred from direct assay

(Romé and Ohkura, 2018)

located_in meiotic spindle pole

inferred from direct assay

(Romé and Ohkura, 2018)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

is_active_in centriole

inferred from biological aspect of ancestor with PANTHER:PTN001871829

(GO Reference Genome Project, 2011-)

is_active_in ciliary basal body

inferred from biological aspect of ancestor with PANTHER:PTN001871829

(GO Reference Genome Project, 2011-)

is_active_in pericentriolar material

inferred from biological aspect of ancestor with PANTHER:PTN001871829

(GO Reference Genome Project, 2011-)

is_active_in spindle pole

inferred from biological aspect of ancestor with PANTHER:PTN001871829

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

GAMMA-TUBULIN RING COMPLEX

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

GAMMA-TUBULIN RING COMPLEX -: Gamma-tubulin ring complex (γ-TuRC) is a multiprotein complex composed of the core subunit G-TUSC (γ-TuSC) and additional Grip-motif proteins to form the ring-shaped complex. G-TURC localizes to the centrosome and catalyze the microtubule nucleation. (Adapted from FBrf0190946).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Grip71 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VJ57)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.51

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Grip71-RA

FBtr0081099

NM_136058

2276

646

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Grip71-PA

FBpp0080649

71.8

646

7.05

Q9VJ57

NP_609902

AAF53698

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Grip71 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Grip71_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.79

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Dobbelaere et al., 2008)

part_of gamma-tubulin complex

inferred from direct assay

(Romé and Ohkura, 2018)

part_of gamma-tubulin ring complex

inferred from direct assay

(Gunawardane et al., 2003)

located_in meiotic spindle midzone

inferred from direct assay

(Romé and Ohkura, 2018)

located_in meiotic spindle pole

inferred from direct assay

(Romé and Ohkura, 2018)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Grip71 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Grip71

View exonic expression by tissue for Dmel\Grip71

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0032705

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35130/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0032705

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0032705

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0032705

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG10346

Flygut - An atlas of the Drosophila adult midgut

FBgn0032705

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Grip71

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 9-10

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 5 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Grip71

Transgenic constructs containing regulatory region of Grip71

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(2L)Exel6041

(Ryder, 2004.4.26)

Df(2L)Exel7071

(Ryder, 2004.4.26)

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die during embryonic stage | maternal effect

Grip71¹²⁰

viable

Grip71¹²⁰

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Grip71^GD6950

viable, with Scer\GAL4^Mef2.PR

Grip71^GD6950

viable, with Scer\GAL4^pnr-MD237

Grip71^GD6950

viable, with Scer\GAL4^tin.CΔ4

Grip71^GD6950

viable (with Df(2L)Exel7071)

Grip71¹²⁰

Sterility

Allele

female sterile

female sterile (with Df(2L)Exel7071)

Grip71¹²⁰

male fertile

Grip71¹²⁰

Other Phenotypes

Allele

abnormal mitotic cell cycle

Grip71^GE30807

short lived

Grip71^GE30807

some die during embryonic stage | maternal effect

Grip71¹²⁰

Phenotype manifest in

Allele

meiotic spindle (with Df(2L)ED119)

Grip71¹²⁰

neuroblast

Grip71^GE30807

spindle

Grip71^GE30807

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (7)

Hsap\NEDD1

5 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (9)

Rnor\Nedd1

5 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (8)

Mmus\Nedd1

5 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (6)

Xtro\serpina3k

3 of 13

Yes

Xtro\nedd1

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (7)

Drer\nedd1

5 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (2)

Cele\npp-23

1 of 14

Yes

Cele\rba-1

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (9)

Agam\AgaP_AGAP007817

9 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (4)

Atha\NEDD1

4 of 13

Yes

Atha\AT3G16650

1 of 13

Atha\LIS

1 of 13

Atha\NFC5

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\LST8

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (3)

Spom\SPAC4F8.11

1 of 12

Yes

Spom\SPAC227.12

1 of 12

Yes

Spom\SPBC3D6.12

1 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Grip71. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (3)

CG3436

1 of 13

Nup43

1 of 13

U4-U6-60K

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

NEDD1; NEDD1 gamma-tubulin ring complex targeting factor

5 of 14

600372

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Grip71 - Cnb

anti tag coimmunoprecipitation, peptide massfingerprinting

(Januschke et al., 2013)

Grip71 - Grip128

anti bait coimmunoprecipitation, molecular weight estimation by staining, western blot

(Gunawardane et al., 2003)

Grip71 - Grip163

anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, molecular weight estimation by staining, cosedimentation through density gradient

(Gunawardane et al., 2003)

Grip71 - Grip84

anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, molecular weight estimation by staining

(Gunawardane et al., 2003)

Grip71 - Grip91

anti tag coimmunoprecipitation, molecular weight estimation by staining, anti bait coimmunoprecipitation, western blot

(Goshima et al., 2008, Gunawardane et al., 2003)

Grip71 - Mzt1

anti tag coimmunoprecipitation, western blot

(Tovey et al., 2018)

Grip71 - cnn

pull down, Identification by mass spectrometry, anti bait coimmunoprecipitation, peptide massfingerprinting, western blot

(Tovey et al., 2021, Habermann et al., 2012)

Grip71 - dgt3

pull down, western blot

(Chen et al., 2017)

Grip71 - dgt5

pull down, western blot

(Chen et al., 2017)

Grip71 - dgt6

anti tag coimmunoprecipitation, western blot, pull down

(Chen et al., 2017, Uehara et al., 2009)

Grip71 - fzr

anti tag coimmunoprecipitation, peptide massfingerprinting

(Meghini et al., 2016)

Grip71 - kel

two hybrid, tandem affinity purification, Identification by mass spectrometry

(Hudson et al., 2019)

Grip71 - sub

anti tag coimmunoprecipitation, western blot

(Romé and Ohkura, 2018)

Grip71 - γTub23C

anti tag coimmunoprecipitation, western blot

(Goshima et al., 2008)

Grip71 - γTub37C

anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, molecular weight estimation by staining, cosedimentation through density gradient

(Tariq et al., 2020, Goshima et al., 2008, Gunawardane et al., 2003)

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

61124

DroID - A comprehensive database of gene and protein interactions.

FBgn0032705

MIST (protein-protein) - An integrated Molecular Interaction Database

35130

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q8SZD0

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-54

Cytogenetic map

37A1-37A1

Sequence location

2L:18,708,846..18,711,297 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

37A1-37A1

Limits computationally determined from genome sequence between P{EP}CG10413^EP2164 and P{lacW}l(2)37Db^k16106&P{lacW}Catsup^k05424

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-54

(FlyBase, 2016)

2-53.4

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (7)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

22406

y¹ w^67c23; P{EPgy2}Grip71^EY20619

NIG-Fly

M2L-2074

y¹ w¹¹¹⁸; Grip71^SK1 P{neoFRT}40A/CyO-Tb

M2L-2075

y¹ w¹¹¹⁸; Grip71^SK2 P{neoFRT}40A/CyO-Tb

2LG-1655

y² VhaAC39-1^cho-1 v¹; P{U6-Grip71.NIG.sgRNA}attP40/CyO

VDRC

v100830

P{KK103377}VIE-260B

v31228

w¹¹¹⁸; P{GD6950}v31228

v318312

PBac{fTRG00961.sfGFP-TVPTBF}VK00033

Genomic Clones (17)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (30)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0032705

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0032705

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Romé and Ohkura, 2018, Tovey et al., 2018)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Grip71 is required for efficient recruitment of pericentriolar material.

(Dobbelaere et al., 2008)

RNAi screen using dsRNA made from templates generated with primers directed against this gene results in the failure of γ-tubulin to localize to the spindle, without affecting its localization to the pole, and the formation of an aberrantly long spindle when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.

(Goshima et al., 2007)

SL2 cells treated with dsRNA against Grip71 show a clear increase in the mitotic index compared to control cells.

(Muller et al., 2006)

Identification: Protein identified as part of the γ tubulin ring complex.

(Gunawardane et al., 2003)

Grip71 associates with Grip163, l(1)dd4, Grip128, Grip84 and γ-Tubulin.

(Gunawardane et al., 2003)

Grip71 may act as a scaffold via its WD repeats in the gamma-tubulin ring complex. Unlike other subunits of the complex, Grip71 does not promote GTP binding to γ-tubulin.

(Gunawardane et al., 2003)

Relationship to Other Genes

Source for database merge of

Additional comments

Source for identity of Grip71 CG10346 was sequence comparison ( date:030311 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: Grip71 CG10346

(FlyBase, 1996-)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

CG10346

(National Institute of Genetics Fly Stocks, 2022-, Hosono et al., 2015, Fukuoh et al., 2014, Moutinho-Pereira et al., 2013, Müller et al., 2010, Keleman et al., 2009.8.5, Dobbelaere et al., 2008, Ducat et al., 2008, Goshima et al., 2007, Giot et al., 2003)

Dgp71WD

(Romé and Ohkura, 2018, Chen et al., 2017, Conduit et al., 2014, Reschen et al., 2012, Bouissou et al., 2009, Moutinho-Pereira et al., 2009, Verollet et al., 2006, Gunawardane et al., 2003)

Dgrip71

(Bouissou et al., 2014, Moutinho-Pereira et al., 2013, Uehara et al., 2009, Wainman et al., 2009, Goshima et al., 2008, Goshima et al., 2007, Goshima et al., 2007, Stumpff et al., 2005, Gunawardane, 2001.12.18)

Gp71WD

(Tariq et al., 2020)

Grip71

(Pang et al., 2021, Weiner et al., 2020, Hudson et al., 2019, Hughes et al., 2018, Romé and Ohkura, 2018, Tillery et al., 2018, Tovey et al., 2018, Meghini et al., 2016, Sarov et al., 2016, Januschke et al., 2013, Habermann et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Müller et al., 2010, Ducat et al., 2008, Muller et al., 2006)

Grip71wd

(Dobbelaere et al., 2008)

grip71

(Zhu et al., 2023)

Name Synonyms

Grip71

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 42 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

35130

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VJ57

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VJ57

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0032705

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35130/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0032705

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0032705

FlyMine - An integrated database for Drosophila genomics

FBgn0032705

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG10346

MARRVEL_MODEL - MARRVEL (model organism gene)

35130

Linkouts

BioGRID - A database of protein and genetic interactions.

61124

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0032705

DroID - A comprehensive database of gene and protein interactions.

FBgn0032705

DRSC - Results frm RNAi screens

FBgn0032705

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Grip71_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0032705

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0032705

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG10346

Flygut - An atlas of the Drosophila adult midgut

FBgn0032705

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

MIST (protein-protein) - An integrated Molecular Interaction Database

35130

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q8SZD0

References (60)

The following external sites may use different assemblies or annotations than FlyBase.

0.79

Report Sections