FB2024_02 , released April 23, 2024
Gene: Dmel\Cad74A
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General Information
Symbol
Dmel\Cad74A
Species
D. melanogaster
Name
Cadherin 74A
Annotation Symbol
CG6445
Feature Type
protein_coding_gene
FlyBase ID
FBgn0036715
Gene Model Status
Current
Stock Availability
5 publicly available
Gene Summary
Cadherin 74A (Cad74A) encodes a non-classical cadherin involved in cell-cell adhesion. [Date last reviewed: 2019-07-11] (FlyBase Gene Snapshot)
All Summaries
Key Links
Genomic Location
Cytogenetic map
74A5-74A6
Sequence location
Recombination map
3-45
RefSeq locus
NT_037436 REGION:17367753..17379530
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (10 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables calcium ion binding
inferred from direct assay
(Lovegrove et al., 2006)
enables protein homodimerization activity
inferred from physical interaction with FLYBASE:Cad74A; FB:FBgn0036715
(Lovegrove et al., 2006)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables calcium ion binding
inferred from electronic annotation with InterPro:IPR002126, InterPro:IPR015919
(InterPro Project Members, 2004-)
Biological Process (5 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
inferred from direct assay
(Lovegrove et al., 2006)
involved_in cell-cell adhesion mediated by cadherin
inferred from direct assay
(Lovegrove et al., 2006)
involved_in dorsal appendage formation
inferred from direct assay
(Zartman et al., 2008)
involved_in homophilic cell adhesion via plasma membrane adhesion molecules
inferred from direct assay
(Lovegrove et al., 2006)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
inferred from sequence or structural similarity
(Hynes and Zhao, 2000)
involved_in cell-cell adhesion
inferred from biological aspect of ancestor with PANTHER:PTN007763440
(GO Reference Genome Project, 2011-)
involved_in homophilic cell adhesion via plasma membrane adhesion molecules
inferred from electronic annotation with InterPro:IPR002126
(InterPro Project Members, 2004-)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in apical plasma membrane
inferred from direct assay
(Zartman et al., 2008, Lovegrove et al., 2006)
located_in microvillus
inferred from direct assay
(Zartman et al., 2008)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in plasma membrane
inferred from sequence or structural similarity
(Hynes and Zhao, 2000)
inferred from electronic annotation with InterPro:IPR020894
(InterPro Project Members, 2004-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Cadherin 74A (Cad74A) encodes a non-classical cadherin involved in cell-cell adhesion. [Date last reviewed: 2019-07-11]
Gene Group (FlyBase)
CADHERINS -
The cadherin superfamily represent a diverse group of transmembrane receptors which mediate cell-cell adhesion. Cadherins are defined by the presence of cadherin domains, typically organised in tandem repeats, which mediate calcium-dependent homophilic interactions between cadherin molecules. (Adapted from FBrf0146675).
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Cad74A for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VVG0)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.55

Gene model reviewed during 5.45

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.40

Gene model reviewed during 5.56

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Cad74A-RA
FBtr0075240
NM_140716
6493
1820
Cad74A-RB
FBtr0075239
NM_168724
6508
1820
Cad74A-RC
FBtr0309231
NM_001259885
6779
1820
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Cad74A-PA
FBpp0075002
201.0
1820
4.57
Q9VVG0
NP_648973
AAF49351
Cad74A-PB
FBpp0075001
201.0
1820
4.57
Q9VVG0
NP_730261
AAN11706
Cad74A-PC
FBpp0301170
201.0
1820
4.57
Q9VVG0
NP_001246814
AFH04485
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1820 aa isoforms: Cad74A-PA, Cad74A-PB, Cad74A-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cad74A using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.30

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 4 -- 6
anterior endoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
central brain anlage in statu nascendi
(Fisher et al., 2012)
foregut anlage in statu nascendi
(Fisher et al., 2012)
antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
anterior endoderm
(Fisher et al., 2012)
mesectoderm
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
embryonic stage 9 -- 12
midline primordium | subset
(Kearney et al., 2004)
embryonic stage 11
midline glial cell
(Wheeler et al., 2006)
embryonic posterior midline glial cell
(Wheeler et al., 2006)
neuroblast MNB
(Wheeler et al., 2006)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
foregut primordium
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
midline primordium
(Fisher et al., 2012)
larval ventral midline glial cell
(Fisher et al., 2012)
pars intercerebralis primordium
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
embryonic stage 13
embryonic posterior midline glial cell
(Wheeler et al., 2006)
embryonic stage 13 -- 16
embryonic epipharynx
(Fisher et al., 2012)
embryonic foregut
(Fisher et al., 2012)
embryonic head epidermis
(Fisher et al., 2012)
embryonic head sensory system
(Fisher et al., 2012)
embryonic hindgut
(Fisher et al., 2012)
embryonic hypopharynx
(Fisher et al., 2012)
embryonic/larval posterior spiracle
(Fisher et al., 2012)
embryonic stage 14 -- 15
spiracular chamber | restricted
(Lovegrove et al., 2006)
oogenesis stage S7 -- S10B
polar follicle cell
(Zartman et al., 2009)
oogenesis stage S8 -- S13
main body follicle cell

Comment: not in roof cells

(Zartman et al., 2009)
oogenesis stage S10 -- S13
follicle cell
(Zartman et al., 2008)
border follicle cell
(Zartman et al., 2008)
oogenesis stage S13
dorsal appendage
(Zartman et al., 2008)
Additional Descriptive Data

Cad74A is expressed in polar cells in early oogenesis. At stage 10B, it is expressed in all follicle cells contacting the oocyte except for the roof cells.

(Zartman et al., 2009)

Cad74A is expressed in a dynamic pattern starting in late oogenesis. From stage S10 and onwards, Cad74A is expressed in all columnar follicle cells except in two dorsolateral patches. It is also expressed in the border cells, but only after migrating from the anterior of the egg chamber to the oocyte/nurse cell boundary. Throughout the later stages of oogenesis, Cad74A is expressed in the floor cells of the dorsal appendages and in the main body follicle cells.

(Zartman et al., 2008)

Several cadherin genes are expressed in an overlapping pattern in the developing posterior spiracles. Cad74A transcript is expressed a group of less elongated spiracle cells. Cad88C and Cad96Cb are expressed in a group of spiracle cells located more deeply in the spiracular chamber than the Cad74A-expressing cells, while Cad86C is expressed in a row of stigmatophore cells surrounding the spiracular chamber.

(Lovegrove et al., 2006)

Expression assayed at stages 9, 11, 13, and 17. Expression may be continuous between assayed stages in some tissues.

(Wheeler et al., 2006)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
oogenesis stage S10 -- S13
follicle cell
(Zartman et al., 2008)
oogenesis stage S13
dorsal appendage
(Zartman et al., 2008)
Additional Descriptive Data

Cad74A localizes to the apical membranes in follicle cells. Punctate expression is observed in dorsal midline and floor cells in stage S11/S12 egg chambers.

(Zartman et al., 2008)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in apical plasma membrane
inferred from direct assay
(Zartman et al., 2008, Lovegrove et al., 2006)
located_in microvillus
inferred from direct assay
(Zartman et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Cad74A in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 4 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Cad74A
Transgenic constructs containing regulatory region of Cad74A
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(3L)Exel6131
(Ryder, 2004.4.26)
Inferred from location ( 0 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (12)
Hsap\CDH23
2 of 14
Yes
No
Hsap\CDHR1
2 of 14
Yes
No
Hsap\FAT1
2 of 14
Yes
No
Hsap\FAT2
2 of 14
Yes
No
Hsap\CDHR2
1 of 14
No
No
Hsap\CELSR1
1 of 14
No
No
Hsap\CELSR2
1 of 14
No
No
Hsap\CELSR3
1 of 14
No
No
Hsap\DCHS1
1 of 14
No
No
Hsap\DCHS2
1 of 14
No
No
Hsap\FAT3
1 of 14
No
No
Hsap\FAT4
1 of 14
No
No
0  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (21)
Rnor\Cdhr2
3 of 14
Yes
No
Rnor\Cdhr1
2 of 14
No
No
Rnor\Fat1
2 of 14
No
No
Rnor\Cdh6
1 of 14
No
No
Rnor\Cdh7
1 of 14
No
No
Rnor\Cdh8
1 of 14
No
No
Rnor\Cdh9
1 of 14
No
No
Rnor\Cdh10
1 of 14
No
No
Rnor\Cdh11
1 of 14
No
No
Rnor\Cdh12
1 of 14
No
No
Rnor\Cdh18
1 of 14
No
No
Rnor\Cdh19
1 of 14
No
No
Rnor\Cdh20
1 of 14
No
No
Rnor\Cdh22
1 of 14
No
No
Rnor\Cdh23
1 of 14
No
No
Rnor\Cdh24
1 of 14
No
No
Rnor\Celsr1
1 of 14
No
No
Rnor\Celsr2
1 of 14
No
No
Rnor\Celsr3
1 of 14
No
No
Rnor\Fat2
1 of 14
No
No
Rnor\Fat4
1 of 14
No
No
Mus musculus (laboratory mouse) (21)
Mmus\Cdhr2
3 of 14
Yes
No
Mmus\Cdhr1
2 of 14
No
No
Mmus\Fat1
2 of 14
No
No
Mmus\Cdh6
1 of 14
No
No
Mmus\Cdh7
1 of 14
No
No
Mmus\Cdh8
1 of 14
No
No
Mmus\Cdh9
1 of 14
No
No
Mmus\Cdh10
1 of 14
No
No
Mmus\Cdh11
1 of 14
No
No
Mmus\Cdh12
1 of 14
No
No
Mmus\Cdh18
1 of 14
No
No
Mmus\Cdh19
1 of 14
No
No
Mmus\Cdh20
1 of 14
No
No
Mmus\Cdh22
1 of 14
No
No
Mmus\Cdh23
1 of 14
No
No
Mmus\Cdh24
1 of 14
No
No
Mmus\Celsr1
1 of 14
No
No
Mmus\Celsr2
1 of 14
No
No
Mmus\Celsr3
1 of 14
No
No
Mmus\Fat2
1 of 14
No
No
Mmus\Fat4
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (11)
Xtro\cdh23
3 of 13
Yes
No
Xtro\fat1
2 of 13
No
No
Xtro\ccdc88a
1 of 13
No
No
Xtro\cdhr1
1 of 13
No
Yes
Xtro\cdhr4
1 of 13
No
Yes
Xtro\celsr3
1 of 13
No
No
Xtro\fat3
1 of 13
No
No
Xtro\fat4
1 of 13
No
No
Xtro\kcng3
1 of 13
No
No
Xtro\LOC100493382
1 of 13
No
No
Xtro\snrpf
1 of 13
No
No
Danio rerio (Zebrafish) (25)
Drer\cdhr1a
2 of 14
Yes
Yes
Drer\fat1a
2 of 14
Yes
No
Drer\fat1b
2 of 14
Yes
No
Drer\cdh6
1 of 14
No
No
Drer\cdh7a
1 of 14
No
No
Drer\cdh10a
1 of 14
No
No
Drer\cdh11
1 of 14
No
No
Drer\cdh12a
1 of 14
No
No
Drer\cdh18a
1 of 14
No
No
Drer\cdh19
1 of 14
No
Yes
Drer\cdh23
1 of 14
No
No
Drer\cdhr2
1 of 14
No
No
Drer\celsr1a
1 of 14
No
No
Drer\celsr1b
1 of 14
No
No
Drer\celsr2
1 of 14
No
No
Drer\celsr3
1 of 14
No
No
Drer\dchs1a
1 of 14
No
No
Drer\fat2
1 of 14
No
No
Drer\fat3a
1 of 14
No
No
Drer\LOC100534755
1 of 14
No
No
Drer\LOC101883589
1 of 14
No
No
Drer\LOC101886358
1 of 14
No
No
Drer\LOC108191765
1 of 14
No
No
Drer\si:ch211-186j3.6
1 of 14
No
No
Drer\si:dkey-22o22.2
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (7)
Cele\cdh-8
4 of 14
Yes
No
Cele\cdh-7
2 of 14
No
Yes
Cele\cdh-1
1 of 14
No
No
Cele\cdh-4
1 of 14
No
No
Cele\cdh-10
1 of 14
No
Yes
Cele\fmi-1
1 of 14
No
No
Cele\hmr-1
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (17)
Agam\AgaP_AGAP006256
11 of 12
Yes
Yes
Agam\AgaP_AGAP001591
3 of 12
No
No
Agam\AgaP_AGAP003579
3 of 12
No
No
Agam\AgaP_AGAP006731
1 of 12
No
No
Agam\AgaP_AGAP006732
1 of 12
No
No
Agam\AgaP_AGAP007203
1 of 12
No
No
Agam\AgaP_AGAP007207
1 of 12
No
No
Agam\AgaP_AGAP007216
1 of 12
No
No
Agam\AgaP_AGAP007905
1 of 12
No
No
Agam\AgaP_AGAP007924
1 of 12
No
No
Agam\AgaP_AGAP009711
1 of 12
No
No
Agam\AgaP_AGAP009716
1 of 12
No
No
Agam\AgaP_AGAP009717
1 of 12
No
No
Agam\AgaP_AGAP009723
1 of 12
No
No
Agam\AgaP_AGAP009726
1 of 12
No
No
Agam\AgaP_AGAP011526
1 of 12
No
No
Agam\GPRSTN
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Cad74A. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (12)
Cad88C
4 of 13
Cad86C
2 of 13
Cad87A
2 of 13
ds
2 of 13
ft
2 of 13
kug
2 of 13
shg
2 of 13
stan
2 of 13
Cad89D
1 of 13
Cad99C
1 of 13
CadN2
1 of 13
CadN
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Show/hide secondary interactors 
    (data from AllianceMine provided by esyN)
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser
    View in Interactions Browser
    Please see the Physical Interaction reports below for full details
    MIST Molecular Interaction Search Tool
    View in MIST tool (external link)
    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    Cad74A
    bead aggregation assay, fluorescence microscopy, inferred by author
    (Lovegrove et al., 2006)
    Summary of Genetic Interactions
    esyN Network Diagram
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3L
    Recombination map
    3-45
    Cytogenetic map
    74A5-74A6
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    74A5-74A6
    Limits computationally determined from genome sequence between P{PZ}Baldspot02281 and P{PZ}blot01658
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location

    3-45

    (FlyBase, 2016)

    3-40.6

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (5)
    Genomic Clones (22)
    cDNA Clones (29)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      Antibody Information
      Laboratory Generated Antibodies
       

      polyclonal

      (Zartman et al., 2008)
      Commercially Available Antibodies
       
      Cell Line Information
      Publicly Available Cell Lines
       
        Other Stable Cell Lines
         
          Other Comments
          Relationship to Other Genes
          Source for database merge of
          Additional comments

          "S(CycEJP)3.1" alleles show no alterations in the "Cad74A" gene (as assayed by Southern analysis).

          (Brumby et al., 2004)
          Nomenclature History
          Source for database identify of
          Nomenclature comments
          Etymology
          Synonyms and Secondary IDs (7)
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          Study result (0)
          Result
          Result Type
          Title
          External Crossreferences and Linkouts ( 38 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
          FlyMine - An integrated database for Drosophila genomics
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MARRVEL_MODEL - MARRVEL (model organism gene)
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          MIST (protein-protein) - An integrated Molecular Interaction Database
          References (51)