FlyBase Gene Report: Dmel\S1P

General Information

Symbol

Dmel\S1P

Species

D. melanogaster

Name

Site-1 protease

Annotation Symbol

CG7169

Feature Type

protein_coding_gene

FlyBase ID

FBgn0037105

Gene Model Status

Current

Stock Availability

2 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

dS1P

Key Links

Genomic Location

Cytogenetic map

78E1-78E1

Sequence location

3L:21,613,797..21,617,376 [-]

Recombination map

3-47

RefSeq locus

NT_037436 REGION:21613797..21617376

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (3 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables serine-type endopeptidase activity

inferred from biological aspect of ancestor with PANTHER:PTN002465698

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR036852

(InterPro Project Members, 2004-)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in proteolysis

inferred from electronic annotation with InterPro:IPR000209, InterPro:IPR036852

(InterPro Project Members, 2004-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in Golgi apparatus

inferred from biological aspect of ancestor with PANTHER:PTN002465706

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

PROPROTEIN CONVERTASES

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

PROPROTEIN CONVERTASES -: Proprotein convertases are serine endopeptidases related to bacterial subtilisin-like enzymes. They activate a broad range of secretory proteins via post-translational cleavage of inactive precursor molecules. The targets and substrates of these convertases are very varied covering many aspects of cellular biology and communication. (Adapted from PMID:22204726.)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\S1P for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VP10)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.46

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

S1P-RA

FBtr0078466

NM_141080

3136

1012

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

S1P-PA

FBpp0078120

114.3

1012

8.35

Q9VP10

NP_649337

AAF51752

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9VP10

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\S1P using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

S1P_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.61

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\S1P in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\S1P

View exonic expression by tissue for Dmel\S1P

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40399/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0037105

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0037105

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0037105

Flygut - An atlas of the Drosophila adult midgut

FBgn0037105

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 0 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 2 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of S1P

Transgenic constructs containing regulatory region of S1P

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

S1P^GD5552

viable, with Scer\GAL4^Mef2.PR

S1P^GD5552

viable, with Scer\GAL4^pnr-MD237

S1P^GD5552

viable, with Scer\GAL4^tin.CΔ4

S1P^GD5552

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (15)

Hsap\MBTPS1

14 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (15)

Rnor\Mbtps1

13 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (15)

Mmus\Mbtps1

13 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (7)

Xtro\mbtps1

6 of 13

Yes

Xtro\vip

2 of 13

Yes

Xtro\htr6

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Danio rerio (Zebrafish) (14)

Drer\mbtps1

14 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (5)

Cele\aex-5

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (5)

Agam\AgaP_AGAP012203

12 of 12

Yes

2 of 12

2 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (56)

Atha\S1P

13 of 13

Yes

Atha\AIR3

1 of 13

Atha\ARA12

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT2G39850

1 of 13

Atha\AT3G14067

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\ATSBT5.2

1 of 13

Atha\SBT1.3

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\SDD1

1 of 13

Yes

Atha\SLP2

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (4)

Scer\PRB1

5 of 13

Yes

Scer\RRT12

5 of 13

Yes

Scer\YSP3

5 of 13

Yes

Scer\KEX2

2 of 13

Schizosaccharomyces pombe (Fission yeast) (4)

Spom\isp6

4 of 12

Yes

Spom\psp3

4 of 12

Yes

Spom\krp1

2 of 12

Spom\tpp2

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:S1P. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (4)

3 of 13

3 of 13

3 of 13

2 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

MBTPS1; membrane bound transcription factor peptidase, site 1

model of spondyloepiphyseal dysplasia Kondo-Fu type

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

MBTPS1; membrane bound transcription factor peptidase, site 1

14 of 14

603355

SPONDYLOEPIPHYSEAL DYSPLASIA, KONDO-FU TYPE; SEDKF

spondyloepiphyseal dysplasia Kondo-Fu type

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

MIST Molecular Interaction Search Tool

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0037105

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

Regulation of cholesterol biosynthesis by SREBP (SREBF)

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Protein processing in endoplasmic reticulum

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9VP10

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-47

Cytogenetic map

78E1-78E1

Sequence location

3L:21,613,797..21,617,376 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

78E1-78E1

Limits computationally determined from genome sequence between P{lacW}l(3)j1B10^j1B10 and P{lacW}l(3)j2C4^j2C4

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-47

(FlyBase, 2016)

3-43.9

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (2)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

67321

y¹ sc^* v¹ sev²¹; P{TRiP.HMC06425}attP40

VDRC

v44999

w¹¹¹⁸; P{GD5552}v44999

Genomic Clones (19)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (15)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

IP02833

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0037105

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0037105

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Additional comments

FlyBase curator comment: the insertion in the "f05271" Exelixis line (PBac{WH}CG11307^f05271) was originally assigned to the S1P gene in FBrf0179797, resulting in the "S1P^f05271" (FBal0159860) allele. However, FBrf0184340 shows that the insertion is actually within CG11307.

(Bloomington Drosophila Stock Center, 2004.11.6)

Source for identity of S1P CG7169 was sequence comparison ( date:020504 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: S1P CG7169

(FlyBase, 1996-)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

CG7169

(Perkins et al., 2009, Bolshakov et al., 2002, Seegmiller et al., 2002)

S1P

(Kumar et al., 2021, Toprak et al., 2020, Tsai et al., 2019, Amarneh et al., 2009)

SKI-1/S1P

(da Palma et al., 2016)

dS1P

(Rawson, 2003, Seegmiller et al., 2002, Seegmiller, 2001.11.1)

Name Synonyms

S1P

Site-1 protease

subtilisin kexin isozyme-1/site-1 protease

(da Palma et al., 2016)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 39 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

40399

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

AF441758

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VP10

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q9VP10

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VP10

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40399/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0037105

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0037105

FlyMine - An integrated database for Drosophila genomics

FBgn0037105

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG7169

MARRVEL_MODEL - MARRVEL (model organism gene)

40399

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0037105

DroID - A comprehensive database of gene and protein interactions.

FBgn0037105

DRSC - Results frm RNAi screens

FBgn0037105

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

S1P_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0037105

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0037105

Flygut - An atlas of the Drosophila adult midgut

FBgn0037105

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0037105

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC002816

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Protein processing in endoplasmic reticulum

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

Regulation of cholesterol biosynthesis by SREBP (SREBF)

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9VP10

References (37)

The following external sites may use different assemblies or annotations than FlyBase.

-0.61

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