PC2, dPC2, Ppp
Please see the JBrowse view of Dmel\amon for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.49
4 (northern blot)
There is only one protein coding transcript and one polypeptide associated with this gene
654 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\amon using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: late embryonic stage 17
Comment: late embryonic stage 17
Comment: late embryonic stage 17
amon transcripts are observed in the third instar larval midgut. The highest levels are found in the anterior midgut and in the anterior-most part of the posterior midgut.
amon-XR transcript is found in the cells of the corpus cardiacum in larva.
amon transcript is first detected in stage 15-16 embryos. Expression peaks in stage 17 embryos. Expression levels are low in larval and most pupal stages, then increase in late pupae and peak in adults. In the embryo, expression is detected in subsets of the nervous systems, endocrine system, and the gut. In late stage 17 embryos, expression is detected in the epiphysis and the antennal maxillary complex, but this expression disappears by mid-first larval instar. The number of amon expressing cells in the brain and ventral nerve cord are approximately 168 in late embryos; this number decreases by about 85% by second instar larval stage. Approximately 4 cells in the middle protocerebrum of the brain maintain high levels of amon expression throughout larval development.
amon immunoreactivity is observed in the larval dorsomedial neurosecretory cells of the larval brain, in paired neurons in the ventral nerve cord, and in endocrine cells in the larval midgut.
JBrowse - Visual display of RNA-Seq signals
View Dmel\amon in JBrowse
3-91
3-88.6
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
amon is required during pupal development for head eversion, leg and wing disc extensin and abdominal differentiation.
The protease encoded by amon cleaves on the carboxyl side of the sequence Lys-Arg.
amon has a role in triggering hatching behaviour.
Larvae lacking amon function have a defect in hatching behaviour; the frequency of head swinging (which in wild-type larvae results in the larvae scraping through the eggshell with their mouth hooks) is greatly reduced and they do not hatch.
Identification: Sequence similarity to the mammalian secretory vesicle associated protease PC2.
The similarity with mammalian and S.cerevisiae proteins suggests a potential role of amon in processing of neuropeptide and hormone precursors.
Source for merge of: amon Ppp
The gene is named "amontillado" from the title of the Edgar Allen Poe story ("The cask of amontillado") about a man who is walled-in while still alive.
