FlyBase Gene Report: Dmel\Prx3

General Information

Symbol

Dmel\Prx3

Species

D. melanogaster

Name

Peroxiredoxin 3

Annotation Symbol

CG5826

Feature Type

protein_coding_gene

FlyBase ID

FBgn0038519

Gene Model Status

Current

Stock Availability

4 publicly available

Enzyme Name (EC)

thioredoxin-dependent peroxiredoxin (1.11.1.24)

Gene Summary

Peroxiredoxin 3 (Prx3) encodes an antioxidant protein involved in hydrogen peroxide catabolism and regulation of apoptosis. [Date last reviewed: 2019-08-01] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

Prx5037, dPrx3, Peroxiredoxin 5037, DPx-5037, DPx5037

Key Links

Genomic Location

Cytogenetic map

90B4-90B4

Sequence location

3R:17,545,222..17,546,531 [-]

Recombination map

3-61

RefSeq locus

NT_033777 REGION:17545222..17546531

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (10 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables peroxiredoxin activity

inferred from direct assay

(McGinnis et al., 2021)

enables thioredoxin-dependent peroxiredoxin activity

inferred from direct assay

(Radyuk et al., 2001)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables peroxiredoxin activity

inferred from electronic annotation with InterPro:IPR019479

(InterPro Project Members, 2004-)

enables thioredoxin peroxidase activity

inferred from biological aspect of ancestor with PANTHER:PTN000073874

(GO Reference Genome Project, 2011-)

Biological Process (5 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

involved_in cell redox homeostasis

inferred from genetic interaction with FLYBASE:Prx5; FB:FBgn0038570

(Radyuk et al., 2010)

involved_in determination of adult lifespan

inferred from genetic interaction with FLYBASE:Prx5; FB:FBgn0038570

(Radyuk et al., 2010)

involved_in hydrogen peroxide catabolic process

inferred from direct assay

(Radyuk et al., 2001)

involved_in negative regulation of apoptotic process

inferred from mutant phenotype

(Radyuk et al., 2010)

inferred from genetic interaction with FLYBASE:Prx5; FB:FBgn0038570

(Radyuk et al., 2010)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in cell redox homeostasis

inferred from biological aspect of ancestor with PANTHER:PTN000073874

(GO Reference Genome Project, 2011-)

involved_in hydrogen peroxide catabolic process

inferred from biological aspect of ancestor with PANTHER:PTN000073874

(GO Reference Genome Project, 2011-)

involved_in response to oxidative stress

inferred from biological aspect of ancestor with PANTHER:PTN000073874

(GO Reference Genome Project, 2011-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in mitochondrion

inferred from high throughput direct assay

(Tan et al., 2009)

inferred from direct assay

(Radyuk et al., 2001)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in cytosol

inferred from biological aspect of ancestor with PANTHER:PTN000073874

(GO Reference Genome Project, 2011-)

is_active_in mitochondrion

inferred from biological aspect of ancestor with PANTHER:PTN002449985

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

PEROXIREDOXINS

Protein Family (UniProt)

Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. (Q9VEJ0)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

thioredoxin-dependent peroxiredoxin activity

[thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O (1.11.1.24)

RHEA 62620: peroxiredoxin activity
RHEA 10008: thioredoxin peroxidase activity
RHEA 63528:

Summaries

Gene Snapshot

Peroxiredoxin 3 (Prx3) encodes an antioxidant protein involved in hydrogen peroxide catabolism and regulation of apoptosis. [Date last reviewed: 2019-08-01]

Gene Group (FlyBase)

PEROXIREDOXINS -: Peroxiredoxins are a family of thiol-dependent antioxidant proteins that catalyze the reduction of hydrogen peroxide, peroxynitrite and a wide range of organic hydroperoxides (ROOH) to the corresponding alcohol (ROH) and water. These proteins function as peroxidases only when coupled to a sulfhydryl-reducing system such as thioredoxin or glutathione. Catalytic activity is dependent on the oxidation of a conserved cysteine residue at the active site. (Adapted from FBrf0139661, PMID:12517450.)

Protein Function (UniProtKB)

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (PubMed:11677042). Plays a role in cell protection against oxidative stress by detoxifying peroxides (PubMed:11677042, PubMed:20869434, PubMed:23124252). May be involved in aging-associated changes in the responsiveness to oxidative stress (PubMed:23124252). Involved in the maintenance of global thiol redox homeostasis (PubMed:20869434). Functions in the central nervous system (CNS) and in motor neurons and is essential for normal motor function (PubMed:33585478, PubMed:33889951).

(UniProt, Q9VEJ0)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Prx3 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VEJ0)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.48

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Prx3-RA

FBtr0083503

NM_079663

1017

234

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Prx3-PA

FBpp0082927

26.4

234

7.59

Q9VEJ0

NP_524387

AAF55431

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Homodimer; disulfide-linked, upon oxidation (PubMed:33920774). 6 homodimers assemble to form a ring-like dodecamer (By similarity). Also exists as a monomer, however the monomeric form is present at a much lower level than the homodimeric form (PubMed:33920774).

(UniProt, Q9VEJ0)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9VEJ0

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Prx3 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Prx3_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

1.23

Transcript Expression

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

organism

(Radyuk et al., 2001)

third instar larval stage

organism

(Radyuk et al., 2001)

pupal stage

organism

(Radyuk et al., 2001)

day 1 of adulthood & male -- day 2 of adulthood & male

organism

(Radyuk et al., 2001)

Additional Descriptive Data

JPrx3 transcript is expressed most intensely in embryos and young adults, and less instensely in third instar larvae and pupae.

(Radyuk et al., 2001)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

day 1 of adulthood & male -- day 2 of adulthood & male

adult thorax

• mitochondrion

(Radyuk et al., 2001)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in mitochondrion

inferred from high throughput direct assay

(Tan et al., 2009)

inferred from direct assay

(Radyuk et al., 2001)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Prx3 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Prx3

View exonic expression by tissue for Dmel\Prx3

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0038519

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42109/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0038519

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0038519

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0038519

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG5826

Flygut - An atlas of the Drosophila adult midgut

FBgn0038519

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 0 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Prx3

Transgenic constructs containing regulatory region of Prx3

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Prx3^GD11779

viable, with Scer\GAL4^Mef2.PR

Prx3^GD11779

viable, with Scer\GAL4^pnr-MD237

Prx3^GD11779

Other Phenotypes

Allele

abnormal stress response, with Scer\GAL4^Appl.G1a

Prx3^UAS.cRa

abnormal stress response, with Scer\GAL4^da.G32

Prx3^RNAi.UAS

increased cell death, with Scer\GAL4^da.G32

Prx3^RNAi.UAS

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (5)

Hsap\PRDX3

12 of 14

Yes

8 of 14

8 of 14

8 of 14

3 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (6)

Rnor\Prdx3

12 of 14

Yes

8 of 14

7 of 14

7 of 14

5 of 14

3 of 14

Mus musculus (laboratory mouse) (6)

Mmus\Prdx3

12 of 14

Yes

8 of 14

7 of 14

6 of 14

3 of 14

3 of 14

Xenopus tropicalis (Western clawed frog) (7)

Xtro\prdx2

6 of 13

Yes

Xtro\prdx1

3 of 13

Yes

Xtro\prdx3

3 of 13

Yes

Xtro\prdx4

3 of 13

Xtro\limk2

2 of 13

Xtro\lemd1

1 of 13

Yes

Xtro\prdx6

1 of 13

Danio rerio (Zebrafish) (5)

Drer\prdx3

12 of 14

Yes

8 of 14

8 of 14

7 of 14

3 of 14

Caenorhabditis elegans (Nematode, roundworm) (3)

Cele\prdx-3

9 of 14

Yes

Cele\prdx-2

8 of 14

Cele\prdx-6

3 of 14

Anopheles gambiae (African malaria mosquito) (5)

Agam\TPX1

12 of 12

Yes

6 of 12

6 of 12

2 of 12

2 of 12

Arabidopsis thaliana (thale-cress) (6)

Atha\2-Cys Prx B

10 of 13

Yes

Atha\AT3G11630

10 of 13

Yes

Atha\PRXQ

3 of 13

Yes

Atha\PER1

2 of 13

Atha\AT3G52960

1 of 13

Atha\TPX1

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (4)

Scer\TSA2

10 of 13

Yes

Scer\TSA1

9 of 13

Scer\PRX1

3 of 13

Scer\DOT5

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\tpx1

8 of 12

Yes

Spom\but1

1 of 12

Escherichia coli (enterobacterium) (2)

Ecol\ahpC

9 of 11

Yes

Ecol\bcp

2 of 11

Yes

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Prx3. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (7)

10 of 13

10 of 13

10 of 13

4 of 13

4 of 13

4 of 13

4 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

spinocerebellar ataxia autosomal recessive 32

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

Prx3^GD11779

model of autosomal recessive spinocerebellar ataxia 32

CEC

(Rebelo et al., 2021)

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

PRDX3; peroxiredoxin 3

model of autosomal recessive spinocerebellar ataxia 32

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PRDX3; peroxiredoxin 3

12 of 14

604769

autosomal recessive spinocerebellar ataxia 32

PRDX1; peroxiredoxin 1

8 of 14

176763

METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA, cblC TYPE; MAHCC

methylmalonic aciduria and homocystinuria type cblC

PRDX2; peroxiredoxin 2

8 of 14

600538

PRDX4; peroxiredoxin 4

8 of 14

300927

PRDX6; peroxiredoxin 6

3 of 14

602316

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Other Interaction Browsers

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Prx3

enhanceable

Prx5

(Radyuk et al., 2010)

Prx5|Prx3

suppressible

Trxr1

(Radyuk et al., 2010)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Prx5

enhanceable

Prx3

(Radyuk et al., 2010)

External Data

Subunit Structure (UniProtKB)

(UniProt, Q9VEJ0 )

Linkouts

BioGRID - A database of protein and genetic interactions.

67142

DroID - A comprehensive database of gene and protein interactions.

FBgn0038519

MIST (protein-protein) - An integrated Molecular Interaction Database

42109

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Detoxification of Reactive Oxygen Species

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-61

Cytogenetic map

90B4-90B4

Sequence location

3R:17,545,222..17,546,531 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

90B4-90B4

Limits computationally determined from genome sequence between P{PZ}l(3)07882⁰⁷⁸⁸² and P{EP}cpo^EP3679

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

90B4-90B5

(Radyuk, 2000.10.5)

Experimentally Determined Recombination Data

Location

3-61

(FlyBase, 2016)

3-59.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (4)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

60475

y¹ v¹; P{TRiP.HMJ22845}attP40/CyO

NIG-Fly

HMJ22845

y¹ v¹; P{TRiP.HMJ22845}attP40/CyO

VDRC

v105617

P{KK100591}VIE-260B

v27521

w¹¹¹⁸; P{GD11779}v27521/CyO

Genomic Clones (13)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (91)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

SD08737

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0038519

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0038519

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

New stable cell line derived from S2-unspecified : Stable S2 cell lines were created to over-express Prx3 or Prx2.
(Radyuk et al., 2003)

Other Comments

S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.

(Stroschein-Stevenson et al., 2006)

Relationship to Other Genes

Source for database merge of

Additional comments

Source for identity of thioredoxin-peroxidase-3 CG5826 was sequence comparison ( date:001223 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: Prx5037 thioredoxin-peroxidase-3

(Orr, 2001.3.5)

Source for identity of: thioredoxin-peroxidase-3 CG5826

(FlyBase, 1996-)

Source for identity of: Prx3 Prx5037

(Radyuk et al., 2010)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (17)

Reported As

Symbol Synonym

CG5826

(Murari et al., 2022, Çiçek et al., 2016, Rosa-Ferreira et al., 2015, Cammarato et al., 2011, Terhzaz et al., 2010, Thornton et al., 2010, Keleman et al., 2009.8.5, Pan and Zhang, 2009, Perkins et al., 2009, Girardot et al., 2004, Orr, 2001.3.5, Radyuk, 2000.10.5)

DPx-5037

(Radyuk et al., 2003, Orr and Radyuk, 2002, Radyuk et al., 2001)

DPx5037

(Detienne et al., 2018, Heifetz and Rivlin, 2010, Orr et al., 2001)

Prx3

(Muita and Baxter, 2023, Ding et al., 2022, Sebastian et al., 2022, Rebelo et al., 2021, Klichko et al., 2019, Calap-Quintana et al., 2015, Bischof and FlyORF project members, 2014.6.20, Kayashima and Yamakawa-Kobayashi, 2012)

Prx5037

(Wang et al., 2014, Mishra et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Munoz-Soriano et al., 2012, Boyd et al., 2011, Wangler et al., 2011, Heifetz and Rivlin, 2010, Terhzaz et al., 2010, Tan et al., 2009, Stroschein-Stevenson et al., 2006)

dPRDX3

(Murari et al., 2022)

dPrx3

(Odnokoz et al., 2023, McGinnis et al., 2021, Bradshaw, 2019, Detienne et al., 2018, Odnokoz et al., 2017, Radyuk et al., 2010)

dprx3

(Klichko et al., 2019, Odnokoz et al., 2017)

mTPx

(Calap-Quintana et al., 2018, Anderson et al., 2008)

mtTPx

(Radyuk et al., 2003)

peroxiredoxin 5037

(Edgar et al., 2012)

Name Synonyms

Peroxiredoxin 3

Peroxiredoxin 5037

(Cammarato et al., 2011, Heifetz and Rivlin, 2010, Tan et al., 2009, Orr et al., 2001)

Thioredoxin peroxidase 3

(de Morais Guedes et al., 2003)

mitochondrial peroxiredoxin

(Anderson et al., 2008)

peroxiredoxin 3

(Radyuk et al., 2010)

thioredoxin-peroxidase-3

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 38 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

42109

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VEJ0

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VEJ0

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VEJ0

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0038519

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42109/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0038519

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0038519

FlyMine - An integrated database for Drosophila genomics

FBgn0038519

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG5826

MARRVEL_MODEL - MARRVEL (model organism gene)

42109

Linkouts

BioGRID - A database of protein and genetic interactions.

67142

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0038519

DroID - A comprehensive database of gene and protein interactions.

FBgn0038519

DRSC - Results frm RNAi screens

FBgn0038519

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Prx3_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0038519

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0038519

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG5826

Flygut - An atlas of the Drosophila adult midgut

FBgn0038519

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0038519

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC012328

MIST (protein-protein) - An integrated Molecular Interaction Database

42109

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Detoxification of Reactive Oxygen Species

References (76)

The following external sites may use different assemblies or annotations than FlyBase.

1.23

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