potassium inward rectifier (Kir) superfamily of channels - inward rectifiers allow a much greater K(+) influx than efflux - osmoregulation - hind gut - Malpighian tubules - regulation of spike discharge frequency and amplitude of the evoked EPSPa at the neuromuscular junction - a principal potassium conductance pathway in the salivary gland that is required for sucrose feeding
Please see the JBrowse view of Dmel\Irk2 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.49
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Irk2 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Irk2 is expressed in adult Malpighian tubules mainly in the spermathecum and in the principal (Type I) cells of the main segment but not in the initial segment.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Irk2 in JBrowse3-80
3-81.1
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: CG4370 CG10180
Source for identity of Irk2 CG4370 was sequence comparison ( date:020109 ).
Source for identity of: Irk2 CG4370