FlyBase Gene Report: Dmel\dj-1β

FB2024_04 , released June 25, 2024

FB2024_04 , released June 25, 2024

Gene: Dmel\dj-1β

General Information

Symbol

Dmel\dj-1β

Species

D. melanogaster

Name

dj-1β

Annotation Symbol

CG1349

Feature Type

protein_coding_gene

FlyBase ID

FBgn0039802

Gene Model Status

Stock Availability

10 publicly available

Enzyme Name (EC)

protein deglycase (3.5.1.124)

Gene Summary

Plays an important role in cell protection against oxidative stress and cell death by acting as a oxidative stress sensor (PubMed:16139214, PubMed:16203113, PubMed:16894167, PubMed:20457924). Does not play a role in methylglyoxal detoxification (PubMed:27903648). Plays a role in mitochondrial function together with Pink1 (PubMed:20457924). In motor neurons regulates structural synaptic plasticity of locomotor behavior as part of the PTEN-phosphatidylinositol 3-kinase pathway in response to oxygen species (ROS) levels (PubMed:30540251). (UniProt, Q9VA37)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

DJ-1, DJ-1b

Key Links

Genomic Location

Cytogenetic map

Sequence location

3R:30,807,117..30,807,978 [+]

Recombination map

3-101

RefSeq locus

NT_033777 REGION:30807117..30807978

Sequence

Get Decorated FASTA

Genomic Maps

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (20 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables peroxiredoxin activity

inferred from sequence or structural similarity with UniProtKB:Q99LX0

(Gene Ontology Curators, 2002-)

enables protein deglycase activity

inferred from sequence or structural similarity with UniProtKB:Q99497

(Gene Ontology Curators, 2002-)

Biological Process (15 terms)

Terms Based on Experimental Evidence (13 terms)

CV Term

Evidence

References

involved_in adult locomotory behavior

inferred from mutant phenotype

(Park et al., 2005)

involved_in cellular response to reactive oxygen species

inferred from mutant phenotype

(Oswald et al., 2018)

acts_upstream_of larval locomotory behavior

inferred from mutant phenotype

(Oswald et al., 2018)

involved_in negative regulation of developmental growth

inferred from mutant phenotype

(Stefanatos et al., 2012)

involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

inferred from mutant phenotype

(Oswald et al., 2018)

involved_in regulation of hydrogen peroxide metabolic process

inferred from mutant phenotype

(Stefanatos et al., 2012)

involved_in regulation of mitochondrial ATP synthesis coupled electron transport

inferred from genetic interaction with FLYBASE:DJ-1α; FB:FBgn0033885

(Hao et al., 2010)

involved_in regulation of neuromuscular synaptic transmission

inferred from mutant phenotype

(Oswald et al., 2018)

involved_in regulation of synaptic plasticity

inferred from mutant phenotype

(Oswald et al., 2018)

inferred from genetic interaction with UniProtKB:P91634

(Oswald et al., 2018)

involved_in response to oxidative stress

inferred from mutant phenotype

(Hwang et al., 2013, Meulener et al., 2006, Menzies et al., 2005, Meulener et al., 2005, Park et al., 2005)

inferred from direct assay

(Lavara-Culebras and Paricio, 2007)

NOT involved_in methylglyoxal metabolic process

inferred from direct assay

(Pfaff et al., 2017)

NOT involved_in protein deglycation, methylglyoxal removal

inferred from direct assay

(Pfaff et al., 2017)

NOT involved_in protein deglycosylation

inferred from direct assay

(Pfaff et al., 2017)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in glycolate biosynthetic process

inferred from biological aspect of ancestor with PANTHER:PTN000866642

(GO Reference Genome Project, 2011-)

involved_in glyoxal metabolic process

inferred from biological aspect of ancestor with PANTHER:PTN000111108

(GO Reference Genome Project, 2011-)

involved_in response to oxidative stress

inferred from biological aspect of ancestor with PANTHER:PTN000111109

(GO Reference Genome Project, 2011-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in mitochondrion

inferred from direct assay

(Park et al., 2005)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN005163920

(GO Reference Genome Project, 2011-)

is_active_in mitochondrion

inferred from biological aspect of ancestor with PANTHER:PTN000111109

(GO Reference Genome Project, 2011-)

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000111109

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

UNCLASSIFIED CARBON-NITROGEN HYDROLASES OF LINEAR AMIDES

Protein Family (UniProt)

-

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

peroxiredoxin activity
RHEA 10008: protein deglycase activity

(1) H2O + N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein] = H(+) + L-arginyl-[protein] + lactate (3.5.1.124)

(2) H2O + N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein] = H(+) + L-lysyl-[protein] + lactate (3.5.1.124)

(3) H2O + S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein] = H(+) + L-cysteinyl-[protein] + lactate (3.5.1.124)

Summaries

Gene Group (FlyBase)

UNCLASSIFIED CARBON-NITROGEN HYDROLASES OF LINEAR AMIDES -: This group comprises carbon-nitrogen hydrolases of linear amides that do not classify under other groups in FlyBase.
PEROXIREDOXINS -: Peroxiredoxins are a family of thiol-dependent antioxidant proteins that catalyze the reduction of hydrogen peroxide, peroxynitrite and a wide range of organic hydroperoxides (ROOH) to the corresponding alcohol (ROH) and water. These proteins function as peroxidases only when coupled to a sulfhydryl-reducing system such as thioredoxin or glutathione. Catalytic activity is dependent on the oxidation of a conserved cysteine residue at the active site. (Adapted from FBrf0139661, PMID:12517450.)

Protein Function (UniProtKB)

Plays an important role in cell protection against oxidative stress and cell death by acting as a oxidative stress sensor (PubMed:16139214, PubMed:16203113, PubMed:16894167, PubMed:20457924). Does not play a role in methylglyoxal detoxification (PubMed:27903648). Plays a role in mitochondrial function together with Pink1 (PubMed:20457924). In motor neurons regulates structural synaptic plasticity of locomotor behavior as part of the PTEN-phosphatidylinositol 3-kinase pathway in response to oxygen species (ROS) levels (PubMed:30540251).

(UniProt, Q9VA37)

Gene Model and Products

Number of Transcripts

1

Number of Unique Polypeptides

1

Please see the JBrowse view of Dmel\dj-1β for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VA37)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

PDB - An information portal to biological macromolecular structures

4E08

Comments on Gene Model

Gene model reviewed during 5.42

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Gene model reviewed during 6.06

Sequence Ontology: Class of Gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0445215

733

187

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

FBpp0401456

19.2

187

5.28

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Post Translational Modification

Oxidation of Cys-45 and Cys-104 in response to oxidative stress (PubMed:16894167, PubMed:22515803). Levels of oxidation increase with age (PubMed:16894167).

(UniProt, Q9VA37)

Crossreferences

InterPro - A database of protein families, domains and functional sites

PDB - An information portal to biological macromolecular structures

4E08

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\dj-1β using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

dj-1beta_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

1.83

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 5 of adulthood & male -- day 7 of adulthood & male

(Dorus et al., 2006)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in mitochondrion

inferred from direct assay

(Park et al., 2005)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\dj-1β in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\dj-1β

View exonic expression by tissue for Dmel\dj-1β

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0039802

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43652/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0039802

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0039802

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0039802

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1349

Flygut - An atlas of the Drosophila adult midgut

FBgn0039802

Images

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 8 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 12 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of dj-1β

Transgenic constructs containing regulatory region of dj-1β

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

(Ryder, 2004.4.26)

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

dj-1β^GD8038

viable, with Scer\GAL4^Mef2.PR

dj-1β^GD8038

viable, with Scer\GAL4^pnr-MD237

dj-1β^GD8038

viable, with Scer\GAL4^tin.CΔ4

dj-1β^GD8038

Sterility

Allele

Other Phenotypes

Allele

abnormal locomotor behavior

dj-1β^GE23381

abnormal locomotor behavior | adult stage

dj-1β^ex54

abnormal locomotor behavior | adult stage | progressive

dj-1β^A286

abnormal locomotor behavior | progressive

abnormal locomotor behavior | recessive

abnormal oxidative stress response | adult stage

dj-1β^ex54

abnormal oxidative stress response | larval stage

dj-1β^ex54

abnormal stress response

dj-1β^A286

abnormal visual perception

dj-1β^Δ93

chemical resistant

chemical sensitive

chemical sensitive | recessive

dj-1β^GE23381

dj-1β^GE23381

radiation sensitive

dj-1β^ex54

Phenotype manifest in

Allele

dopaminergic neuron

dopaminergic neuron | adult stage

dj-1β^ex54

dorso-lateral dopaminergic neuron

dj-1β^ex54

embryonic/larval brain

dj-1β^ex54

dj-1β^GE23381

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (1)

13 of 14

Yes

No

3

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (1)

13 of 14

Yes

No

Mus musculus (laboratory mouse) (1)

12 of 14

Yes

No

Xenopus tropicalis (Western clawed frog) (1)

7 of 13

Yes

Yes

Danio rerio (Zebrafish) (1)

13 of 14

Yes

Yes

Caenorhabditis elegans (Nematode, roundworm) (2)

13 of 14

Yes

No

13 of 14

Yes

No

Anopheles gambiae (African malaria mosquito) (1)

Agam\AgaP_AGAP000705

10 of 12

Yes

No

Arabidopsis thaliana (thale-cress) (6)

8 of 13

Yes

No

8 of 13

Yes

No

7 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\SPAC22E12.03c

10 of 12

Yes

No

Escherichia coli (enterobacterium) (2)

8 of 11

Yes

No

1 of 11

No

No

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:dj-1β. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (1)

12 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Parkinson disease 7, early-onset

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 5 )

Allele

Disease

Evidence

References

model of early-onset Parkinson's disease

CEA

(West et al., 2015)

model of Parkinson's disease

CEA with DJ-1α^Δ72

(Hao et al., 2010)

CEA

(Hao et al., 2010)

model of Parkinson's disease 7

CEA

(Heremans et al., 2022, Dwivedi and Lakhotia, 2016)

model of Parkinson's disease 7

CEA

(Sanz et al., 2017, Lavara-Culebras and Paricio, 2007)

model of Parkinson's disease 7

CEA

(Fernandez-Ayala et al., 2009, Park et al., 2005)

model of Parkinson's disease 7

CEA

(Lee et al., 2022, Park et al., 2005)

model of Parkinson's disease

CEA

(Hwang et al., 2013)

model of Parkinson's disease 7

CEC

(Martinez-Perez et al., 2018)

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

PARK7; Parkinsonism associated deglycase

model of Parkinson's disease 7

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 4 )

Allele

Disease

Interaction

References

ameliorates Parkinson's disease

modeled by Hsc70-5^KK100233

(Zhu et al., 2021)

ameliorates Parkinson's disease

modeled by Pink1^B9

(Hao et al., 2010)

model of Parkinson's disease 7

is ameliorated by Pdk^UAS.Tag:HA

(Lee et al., 2022)

is ameliorated by Pdp^G1628

(Lee et al., 2022)

is ameliorated by Vhl¹

(Lee et al., 2022)

is ameliorated by sima^UAS.cBa

(Lee et al., 2022)

is ameliorated by Cyp1^EP1073

(Kim et al., 2018)

model of Parkinson's disease

is ameliorated by Daxx¹

(Hwang et al., 2013)

dj-1β^C45A.UAS

ameliorates Parkinson's disease

modeled by Pink1^B9

(Hao et al., 2010)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PARK7; Parkinsonism associated deglycase

13 of 14

PARKINSON DISEASE 7, AUTOSOMAL RECESSIVE EARLY-ONSET; PARK7

Parkinson's disease 7

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Dmel gene

Ortholog showing functional complementation

Supporting References

(Meulener et al., 2006)

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

On

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

RNA-protein

Physical Interaction

Assay

References

anti bait coimmunoprecipitation, quantitative reverse transcription pcr

(Lu et al., 2014)

anti tag coimmunoprecipitation, quantitative reverse transcription pcr

(Lu et al., 2014)

protein-protein

Physical Interaction

Assay

References

dj-1β - Fkbp14

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Hwang et al., 2013)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Meng et al., 2017)

suppressible

(Hwang et al., 2013)

suppressible

(Zhu et al., 2021)

suppressible

(Hao et al., 2010)

suppressible

(Aron et al., 2010)

suppressible

(Aron et al., 2010)

suppressible

(Aron et al., 2010)

suppressible

(Aron et al., 2010)

enhanceable

(Aron et al., 2010)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0039802

MIST (genetic) - An integrated Molecular Interaction Database

43652

MIST (protein-protein) - An integrated Molecular Interaction Database

43652

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Aggrephagy

Genomic Location and Detailed Mapping Data

Chromosome (arm)

3R

Recombination map

3-101

Cytogenetic map

Sequence location

3R:30,807,117..30,807,978 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

100A5-100A5

Limits computationally determined from genome sequence between P{PZ}ncd⁰⁵⁸⁸⁴ and P{lacW}l(3)s2500^s2500

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-101

(FlyBase, 2016)

3-98.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (10)

Aberrations including deletions of this gene Aberrations including duplications of this gene

33604

w¹¹¹⁸; P{UAS-dj-1β.M}7

33601

w¹¹¹⁸; dj-1β^Δ93

31859

w¹¹¹⁸; P{EP}dj-1β^G19993

31261

y¹ v¹; P{TRiP.JF01202}attP2

38378

y¹ v¹; P{TRiP.HMS01847}attP40

33602

w¹¹¹⁸; DJ-1α^Δ72; dj-1β^Δ93

16085

y¹ w¹¹¹⁸; PBac{5HPw⁺}dj-1β^A286

38999

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01915}attP2

v103336

P{KK112912}VIE-260B

v17214

w¹¹¹⁸; P{GD8038}v17214

Genomic Clones (13)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (37)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GH09983

Other clones

DPiM_GH09983

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0039802

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0039802

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Martinez-Perez et al., 2018, Oswald et al., 2018)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dj-1β plays a role in the survival of dopaminergic neurons.

(Menzies et al., 2005)

Relationship to Other Genes

Source for database merge of

Additional comments

Source for identity of dj-1β CG1349 was sequence comparison ( date:020211 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: dj-1β CG1349

(FlyBase, 1996-)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (13)

Reported As

Symbol Synonym

CG1349

(Ibaraki et al., 2021, Lu et al., 2014, Ni et al., 2010.12.1, Zhang et al., 2010, Keleman et al., 2009.8.5, Ni et al., 2008, Lavara-Culebras and Paricio, 2007, Menzies et al., 2005, Meulener et al., 2005, Park et al., 2005)

DJ-1

(Bajracharya et al., 2019, Scheckhuber, 2019, Xiong and Yu, 2018, Biskup and Moore, 2006, Meulener et al., 2006, Pallanck and Greenamyre, 2006)

DJ-1 beta

(Ham et al., 2021)

DJ-1B

(Aron et al., 2010, Yang et al., 2005)

DJ-1b

(Zhou et al., 2022, Meng et al., 2017, Hao et al., 2010, van der Brug et al., 2008, Meulener et al., 2006)

DJ1-1β

(Naz and Siddique, 2021)

Dj-1β

(Zhu et al., 2021)

dDJ-1beta

(Breger and Fuzzati Armentero, 2019)

dj-1b

(Szibor et al., 2022)

dj-1beta

(Chen et al., 2020, Zarubin et al., 2020, Lu et al., 2014, Mukherjee et al., 2014, Pezzulo et al., 2012, Sanz et al., 2010, Dorus et al., 2006)

dj-1β

(Asthana and Shravage, 2022, De Lazzari et al., 2022, Rounds et al., 2022, Ibaraki et al., 2021, Turnell et al., 2021, Turnell et al., 2021, Vos and Klein, 2021, Zhu et al., 2021, De Lazzari et al., 2020, Aryal and Lee, 2019, Evangelakou et al., 2019, Martinez-Perez et al., 2018, Vanhauwaert and Verstreken, 2015, Sanz et al., 2010, Fernandez-Ayala et al., 2009)

dj1-β

(Sanz, 2016)

Name Synonyms

DJ-1B

(Aron et al., 2010)

dj-1β

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 38 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

43652

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VA37

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VA37

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VA37

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0039802

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43652/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0039802

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0039802

FlyMine - An integrated database for Drosophila genomics

FBgn0039802

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG1349

MARRVEL_MODEL - MARRVEL (model organism gene)

43652

PDB - An information portal to biological macromolecular structures

4E08

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0039802

DroID - A comprehensive database of gene and protein interactions.

FBgn0039802

DRSC - Results frm RNAi screens

FBgn0039802

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

dj-1beta_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0039802

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0039802

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1349

Flygut - An atlas of the Drosophila adult midgut

FBgn0039802

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0039802

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC014965

MIST (genetic) - An integrated Molecular Interaction Database

43652

MIST (protein-protein) - An integrated Molecular Interaction Database

43652

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Aggrephagy

References (107)