FlyBase Gene Report: Dmel\CG42814

General Information

Symbol

Dmel\CG42814

Species

D. melanogaster

Name

Annotation Symbol

CG42814

Feature Type

protein_coding_gene

FlyBase ID

FBgn0261996

Gene Model Status

Current

Stock Availability

4 publicly available

Enzyme Name (EC)

UDP-sugar diphosphatase (3.6.1.45)

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

97E10-97E10

Sequence location

3R:27,228,673..27,229,468 [-]

Recombination map

3-92

RefSeq locus

NT_033777 REGION:27228673..27229468

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (5 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

inferred from electronic annotation with InterPro:IPR004385

(InterPro Project Members, 2004-)

enables metal ion binding

inferred from electronic annotation with InterPro:IPR004385

(InterPro Project Members, 2004-)

enables UDP-sugar diphosphatase activity

inferred from biological aspect of ancestor with PANTHER:PTN000931669

(GO Reference Genome Project, 2011-)

Biological Process (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in nucleoside phosphate metabolic process

inferred from biological aspect of ancestor with PANTHER:PTN000217263

(GO Reference Genome Project, 2011-)

involved_in ribose phosphate metabolic process

inferred from biological aspect of ancestor with PANTHER:PTN000217263

(GO Reference Genome Project, 2011-)

Cellular Component (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

UDP-SUGAR DIPHOSPHATASES

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

UDP-sugar diphosphatase activity

UDP-sugar + H2O = UMP + alpha-D-aldose 1-phosphate (3.6.1.45)

Summaries

Gene Group (FlyBase)

UDP-SUGAR DIPHOSPHATASES -: Uridine diphosphate (UDP)-sugar diphosphatases catalyze the hydrolysis of a UDP-sugar to produce uridine monophosphate and sugar-1-phosphate.

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\CG42814 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry F3YD80)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.49

Sequence Ontology: Class of Gene

nuclear_gene

(FlyBase Genome Annotators, 2010)

protein_coding_gene

(FlyBase Genome Annotators, 2010)

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CG42814-RA

FBtr0303824

NM_001202372

796

237

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

CG42814-PA

FBpp0292831

25.9

237

5.39

F3YD80

NP_001189301

ADV37391

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

F3YD80

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG42814 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG42814_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

5.12

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\CG42814 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CG42814

View exonic expression by tissue for Dmel\CG42814

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

10178958/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0261996

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0261996

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 1 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 3 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CG42814

Transgenic constructs containing regulatory region of CG42814

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

CG42814^f07185

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

CG42814^GD10151

viable, with Scer\GAL4^Mef2.PR

CG42814^GD10151

viable, with Scer\GAL4^pnr-MD237

CG42814^GD10151

viable, with Scer\GAL4^tin.CΔ4

CG42814^GD10151

Sterility

Allele

fertile

CG42814^f07185

Other Phenotypes

Allele

short lived | heat sensitive, with Scer\GAL4^tin.CΔ4

CG42814^GD10151

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (19)

Hsap\NUDT14

13 of 14

Yes

Hsap\NUDT5

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (15)

Rnor\Nudt14

13 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (19)

Mmus\Nudt14

12 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (4)

Xtro\LOC100495877

1 of 13

Yes

Xtro\mpp2

1 of 13

Yes

Xtro\serpind1

1 of 13

Yes

Xtro\trac

1 of 13

Yes

Danio rerio (Zebrafish) (16)

Drer\nudt14

13 of 14

Yes

Drer\nudt5

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (7)

Cele\C50F4.16

7 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (9)

Agam\AgaP_AGAP004158

8 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (17)

Atha\DCP2

1 of 13

Yes

Atha\NUDT3

1 of 13

Yes

Atha\NUDT4

1 of 13

Yes

Atha\NUDT11

1 of 13

Yes

Atha\NUDT12

1 of 13

Yes

Atha\NUDT16

1 of 13

Yes

Atha\NUDT17

1 of 13

Yes

Atha\NUDT18

1 of 13

Yes

Atha\NUDT20

1 of 13

Yes

Atha\NUDT21

1 of 13

Yes

Atha\NUDT22

1 of 13

Yes

Atha\NUDT24

1 of 13

Yes

Atha\NUDX13

1 of 13

Yes

Atha\NUDX14

1 of 13

Yes

Atha\NUDX15

1 of 13

Yes

Atha\NUDX25

1 of 13

Yes

Atha\NUDX26

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (5)

Scer\YSA1

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (6)

Spom\aps1

1 of 12

Yes

Spom\dcp2

1 of 12

Yes

Spom\pcd1

1 of 12

Yes

Spom\SPAC14C4.10c

1 of 12

Yes

Spom\SPBP35G2.12

1 of 12

Yes

Spom\tnr3

1 of 12

Yes

Escherichia coli (enterobacterium) (9)

Ecol\nudK

8 of 11

Yes

Ecol\nudF

4 of 11

Yes

2 of 11

1 of 11

1 of 11

1 of 11

1 of 11

1 of 11

1 of 11

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:CG42814. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (12)

CG42813

12 of 13

Aps

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

NUDT14; nudix hydrolase 14

13 of 14

609219

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

MIST Molecular Interaction Search Tool

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-92

Cytogenetic map

97E10-97E10

Sequence location

3R:27,228,673..27,229,468 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

97E10-97E10

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-92

(FlyBase, 2016)

3-90.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (4)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

19054

w¹¹¹⁸; PBac{WH}CG42814^f07185

60088

y¹ sc^* v¹ sev²¹; P{TRiP.HMC05082}attP40

VDRC

v108204

P{KK100663}VIE-260B

v45246

w¹¹¹⁸; P{GD10151}v45246

Genomic Clones (15)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (1)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

MIP29220

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0261996

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0261996

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Comments: dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R[+] cell morphology.

(Kiger et al., 2003)

Relationship to Other Genes

Source for database merge of

Additional comments

Source for split of: CG31063

(FlyBase Genome Annotators, 2010)

Annotation CG31063 split into CG42813 and CG42814 in release 5.30 of the genome annotation.

(FlyBase Genome Annotators, 2010)

Source for split of: CG6001

(FlyBase Genome Annotators, 2002-2003)

Annotation CG6001 split into CG31063 and CG31064 in release 3 of the genome annotation. In addition, release 3 annotation CG31064 contains sequences corresponding to release 2 annotation CG14261.

(FlyBase Genome Annotators, 2002-2003)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

CG31063

(FlyBase Genome Annotators, 2010, Keleman et al., 2009.8.5, Dickson et al., 2007.7.18, InterPro Project Members, 2004-, Giot et al., 2003, Kiger et al., 2003, FlyBase Genome Annotators, 2002-2003)

CG42814

(Perkins et al., 2009)

CG6001

(FlyBase Genome Annotators, 2002-2003)

Name Synonyms

Secondary FlyBase IDs

FBgn0051063
FBan0031063
FBgn0039496

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 21 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

10178958

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

ADV37391

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

F3YD80

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

F3YD80

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

F3YD80

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

10178958/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0261996

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0261996

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG42814

MARRVEL_MODEL - MARRVEL (model organism gene)

10178958

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0261996

DRSC - Results frm RNAi screens

FBgn0261996

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG42814_1

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0261996

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

References (18)

The following external sites may use different assemblies or annotations than FlyBase.

5.12

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