Dm_X:51771 , lincRNA.975
cytoplasmic protein that acts as the β subunit and redox sensor of Shaker voltage-dependent K+ channels - functional in neural pathway in arousal and circadian rhythms - interacts with Ether go-go channels
Please see the JBrowse view of Dmel\Hk for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.51
Gene model reviewed during 5.44
Gene model reviewed during 5.55
Gene model reviewed during 6.01
Multiphase exon postulated: reading frame of first coding exon differs in alternative transcripts.
Double stop-codon suppression (UGA, UGA) postulated; FBrf0216884.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.48
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
~9 (northern blot)
546 (aa); 60 (kD predicted)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Hk using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Eye-enriched transcripts determined by ratio of expression level in wild-type heads. versus expression level in so heads.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Hk in JBrowse1-31
1-32.5
1-30.9 +/- 0.6
1-30.4 +/- 0.6
1-30.5
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Duplicate transcripts identified and eliminated during the migration of annotations from the release 5 genome assembly to the release 6 assembly.
New annotation (CG34319) in release 5.2 of the genome annotation.
RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
Mutants are hypersensitive to paraquat.
Alteration of the rate of aging and life span using Sh and Hk hyperactive mutants shows that the timing of type I Ecol\lacZ2216 expression is independent of metabolic rate.
Hk β subunit modulates a wide range of the Sh K+ current properties, inducing its amplitude, activation and inactivation, temperature dependence and drug sensitivity. Modulation is thought to occur via hydrophobic interactions, Hk β subunits modulate Sh channel formation in the cytoplasmic pore region.
The entire adult temporal pattern of expression of an enhancer trap element, P{lacW}1085, scales to life span in Hk1 and Sh5 mutants.
Source for merge of: Hk CG17779
Source for merge of: Hk CG34319
Annotations CG32688 and CG34319 merged as CG43388 in release 5.37 of the genome annotation.
Annotations CG17779 and CG2287 merged as CG32688 in release 3 of the genome annotation.
Additional γ ray-induced alleles have been isolated by K. Schlimgen on the basis of their failure to complement the leg shaking of Hk1 (FBrf0050361).
