FlyBase Gene Report: Dmel\CCT8

General Information

Symbol

Dmel\CCT8

Species

D. melanogaster

Name

Chaperonin containing TCP1 subunit 8

Annotation Symbol

CG8258

Feature Type

protein_coding_gene

FlyBase ID

FBgn0284436

Gene Model Status

Current

Stock Availability

5 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

44F5-44F5

Sequence location

2R:8,904,844..8,906,990 [-]

Recombination map

2-59

RefSeq locus

NT_033778 REGION:8904844..8906990

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (7 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables ATP binding

inferred from electronic annotation with InterPro:IPR002194, InterPro:IPR002423, InterPro:IPR012721

(InterPro Project Members, 2004-)

enables ATP hydrolysis activity

inferred from electronic annotation with InterPro:IPR002194, InterPro:IPR012721

(InterPro Project Members, 2004-)

enables ATP-dependent protein folding chaperone

inferred from electronic annotation with InterPro:IPR017998

(InterPro Project Members, 2004-)

enables unfolded protein binding

inferred from electronic annotation with InterPro:IPR002194, InterPro:IPR012721

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN004253040

(GO Reference Genome Project, 2011-)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in protein folding

inferred from biological aspect of ancestor with PANTHER:PTN004253040

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR002194, InterPro:IPR012721

(InterPro Project Members, 2004-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in plasma membrane

inferred from high throughput direct assay

(Tan et al., 2009)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

part_of chaperonin-containing T-complex

inferred from biological aspect of ancestor with PANTHER:PTN000144200

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

CHAPERONIN CONTAINING TCP-1 COMPLEX

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

ATP hydrolysis activity
RHEA 13065:

Summaries

Gene Group (FlyBase)

CHAPERONIN CONTAINING TCP-1 COMPLEX -: Group II Heat Shock Protein 60 chaperonins are paralogous subunits that assemble to form a multi-subunit ring complex, the TCP-1 Ring Complex (TRiC) or Chaperonin Containing TCP-1 (CCT) complex. Within the cytoplasm, TRiC/CCT catalyses the ATP-dependent folding of approximately 10% of of newly synthesized proteins. (Adapted from FBrf0210519, FBrf0232269 and PMID:11580267).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\CCT8 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q7K3J0)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.49

Sequence Ontology: Class of Gene

gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CCT8-RA

FBtr0088683

NM_136574

1904

546

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

CCT8-PA

FBpp0087764

59.4

546

4.94

Q7K3J0

NP_610418

AAF59029

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q7K3J0

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CCT8 using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.63

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

anterior endoderm

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 11 -- 12

anal pad primordium

Comment: reported as anal pad specific anlage

(Fisher et al., 2012)

anterior midgut primordium

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

hindgut proper primordium

(Fisher et al., 2012)

Malpighian tubule primordium

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

somatic muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)

visceral muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 13 -- 16

dorsal pharyngeal muscle cell

(Fisher et al., 2012)

embryonic anal pad

(Fisher et al., 2012)

embryonic hindgut

(Fisher et al., 2012)

embryonic Malpighian tubule

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

embryonic/larval muscle system

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in plasma membrane

inferred from high throughput direct assay

(Tan et al., 2009)

Expression Deduced from Reporters

Reporter: PBac{768.FSVS-0}CCT8^CPTI003689

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

glial cell of adult brain cell body rind

Comment: adult brain cortex and glial sheath

(Knowles-Barley, 2011.8.24)

adult brain cell body rind | restricted

Comment: some parts of the adult brain cortex

(Knowles-Barley, 2011.8.24)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\CCT8 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CCT8

View exonic expression by tissue for Dmel\CCT8

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35882/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0284436

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0033342

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0284436

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 4 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 3 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CCT8

Transgenic constructs containing regulatory region of CCT8

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(2R)BSC268

(Kahsai et al., 2016)

Df(2R)Exel8048

(Ryder, 2004.4.26)

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^Act5C.PI

CCT8^GD13863

lethal (with Df(2R)BSC268)

CCT8⁰³⁹⁹⁶

lethal | recessive

lethal - all die during larval stage, with Scer\GAL4^Mef2.PR

CCT8^GD13863

lethal - all die during pharate adult stage, with Scer\GAL4^ey.PU

partially lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

CCT8^GD13863

partially lethal, with Scer\GAL4^tin.CΔ4

CCT8^GD13863

partially lethal - majority die

CCT8⁰³⁹⁹⁶

Other Phenotypes

Allele

some die during pupal stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

CCT8^GD13863

visible | pharate adult stage, with Scer\GAL4^ey.PU

Phenotype manifest in

Allele

adult head | pharate adult stage, with Scer\GAL4^ey.PU

eye, with Scer\GAL4^ey.PH

CCT8^GD13863

sarcomere, with Scer\GAL4^Mef2.PR

CCT8^GD13863

Z disc, with Scer\GAL4^Mef2.PR

CCT8^GD13863

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (11)

Hsap\CCT8

14 of 14

Yes

Hsap\CCT8L2

4 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (10)

Rnor\Cct8

14 of 14

Yes

Rnor\Cct8l1

4 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (10)

Mmus\Cct8

14 of 14

Yes

Mmus\Cct8l1

3 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (6)

Xtro\cct8

8 of 13

Yes

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (7)

Drer\cct8

14 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (8)

Cele\cct-8

13 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (8)

Agam\AgaP_AGAP010588

12 of 12

Yes

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (9)

Atha\AT3G03960

13 of 13

Yes

Atha\AT4G08640

2 of 13

Yes

Atha\AT1G24510

1 of 13

Atha\AT1G48095

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (7)

Scer\CCT8

13 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (7)

Spom\cct8

12 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:CCT8. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (12)

4 of 13

4 of 13

4 of 13

3 of 13

3 of 13

3 of 13

3 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

CCT8^KK100186

exacerbates frontotemporal dementia and/or amyotrophic lateral sclerosis-1

modeled by Zzzz\GGGGCC^36.UAS

(Ortega et al., 2020)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CCT8; chaperonin containing TCP1 subunit 8

14 of 14

617786

CCT8L2; chaperonin containing TCP1 subunit 8 like 2

4 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

MIST Molecular Interaction Search Tool

View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

CCT8 - Akt

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

CCT8 - CCT1

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - CCT2

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - CCT3

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - CCT4

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - CCT5

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - CCT6

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - CCT7

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - CG1371

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - CG3008

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - CG33303

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - Chc

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - Cndp2

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - Cnx99A

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - Cyp12d1-p

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - DCAF12

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - FASN1

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - Fatp1

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - Gfat2

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - Glt

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - GluProRS

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - Gp210

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - Gp93

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - Idh3a

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - Ipo9

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - Kap-α3

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - Kr-h2

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - MRP

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - Mcad

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - Mec2

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - Mettl14

pull down, anti tag western blot, anti tag coimmunoprecipitation

(Tang et al., 2021)

CCT8 - Mettl3

anti tag coimmunoprecipitation, anti tag western blot, pull down

(Tang et al., 2021)

CCT8 - Mpcp2

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - Nfs1

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - Ost48

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - OstΔ

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - Past1

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - Pi3K68D

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - Pp2A-29B

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - Psa

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - Rab7

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - Rdh1

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - Rpn1

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - Rpt1

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - Rpt6

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - ScsβA

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - ScsβG

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - Sec61α

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - SerRS

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - TER94

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - UQCR-6.4

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - UQCR-C2

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - Vps4

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - boca

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - bor

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - fax

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - mst

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Palumbo et al., 2015)

CCT8 - shd

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - spidey

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - viaf

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - wal

experimental knowledge based

(Guruharsha et al., 2011)

CCT8 - βCOP

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

CCT8

(Abrell et al., 2000)

External Data

Linkouts

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-59

Cytogenetic map

44F5-44F5

Sequence location

2R:8,904,844..8,906,990 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

44F5-44F5

Limits computationally determined from genome sequence between P{lacW}Dmn^k16109&P{lacW}Gγ1^k08017 and P{lacW}babo^k16912

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

44F3-44F4

(determined by in situ hybridisation)

(Spradling et al., 1999)

44F3-44F4

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

2-59

(FlyBase, 2016)

2-57.9

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (5)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

11361

cn¹ P{PZ}CCT8⁰³⁹⁹⁶/CyO; ry⁵⁰⁶

Kyoto

115440

w¹¹¹⁸; PBac{768.FSVS-0}CCT8^CPTI003689

VDRC

v103905

P{KK100186}VIE-260B

v45790

w¹¹¹⁸; P{GD13863}v45790

v45789

w¹¹¹⁸; P{GD13863}v45789/TM3

Genomic Clones (11)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (106)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD24495

Other clones

DPiM_LD24495

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Source for merge of: CG8258 l(2)03996

(Monzo et al., 2010)

Additional comments

"l(2)03996" probably corresponds to "CG8258"; the P{PZ} insertion in the "l(2)03996⁰³⁹⁹⁶" allele maps 7bp upstream of the 5' end of the CT8297 transcript of "CG8258".

(Misra, 2000.8.25)

Nomenclature History

Source for database identify of

Source for identity of: CCT8 CG8258

(Monzo et al., 2010)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

CCT8

(Heigwer et al., 2023, Perlegos et al., 2022, Uçkun et al., 2021, Kim and Choi, 2019, Hassan et al., 2018, Levis, 2018.8.30, Monzo et al., 2010)

Q7K3J0_DROME

(Fukuyama et al., 2012)

TCP-1θ

(Monzo et al., 2010)

TCP1-theta

(Palumbo et al., 2015)

Tcp1-theta

(Fisher et al., 2008)

cct8

(Ohhara et al., 2019, Monzo et al., 2010)

l(2)03996

Name Synonyms

Chaperonin containing TCP1 subunit 8

lethal (2) 03996

Secondary FlyBase IDs

FBgn0033342
FBgn0010562

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 29 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

35882

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q7K3J0

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q7K3J0

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q7K3J0

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35882/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0284436

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0284436

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG8258

MARRVEL_MODEL - MARRVEL (model organism gene)

35882

Linkouts

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0033342

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0284436

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (78)

The following external sites may use different assemblies or annotations than FlyBase.

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