FB2024_04 , released June 25, 2024
Human Disease Model Report: high-sugar diet, insulin pathway effects
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General Information
Name
high-sugar diet, insulin pathway effects
FlyBase ID
FBhh0000496
Disease Ontology Term
Parent Disease
OMIM
Overview

Multiple studies have assessed the effects of a high-sugar diet on flies, using larval or adult stages. Phenotypes of type 2 diabetes are observed in animals cultured on a high-sugar diet, including hyperglycemia and insulin resistance; cardiomyopathy (see FBhh0000482) and nephropathy (see FBhh0001117) are also observed. Comparative analyses of gene expression in control animals vs. high-sugar-fed animals has allowed identification of affected genes and pathways. Genes that ameliorate or otherwise modify effects of a high-sugar diet have been identified.

[updated Oct. 2019 by FlyBase; FBrf0222196]

Disease Summary Information
Disease Summary: high-sugar diet, insulin pathway effects
OMIM report
Human gene(s) implicated
Symptoms and phenotype
Genetics
Cellular phenotype and pathology
Molecular information
External links
    Disease synonyms
    diabesity
    HS diet, insulin pathway effects
    Ortholog Information
    Human gene(s) in FlyBase
      Other mammalian ortholog(s) used
        D. melanogaster Gene Information (0)
        Other Genes Used: Viral, Bacterial, Synthetic (0)
          Summary of Physical Interactions (0 groups)
          Alleles Reported to Model Human Disease (Disease Ontology) (0 alleles)
          Alleles Representing Disease-Implicated Variants
          Genetic Tools, Stocks and Reagents
          Sources of Stocks
          Contact lab of origin for a reagent not available from a public stock center.
          Bloomington Stock Center Disease Page
          Related mammalian, viral, bacterial, or synthetic transgenes
          Allele
          Transgene
          Publicly Available Stocks
          Selected Drosophila transgenes
          Allele
          Transgene
          Publicly Available Stocks
          RNAi constructs available
          Allele
          Transgene
          Publicly Available Stocks
          Selected Drosophila classical alleles
          Allele
          Allele class
          Mutagen
          Publicly Available Stocks
          References (96)