Exposure by feeding to levodopa (L-dopa) or chlorpromazine induces depression-like phenotypes in Drosophila adults, including reduction of appetite and sexual activity; key biochemical markers are also observed to change. Assessed using RNA-seq and QRT-PCR experiments, changes in gene expression after exposure to chlorpromazine have been characterized.
See the FlyBase chemical reports for L-dopa (FBch0000146), chlorpromazine (FBch0000035).
[updated Mar. 2024 by FlyBase; FBrf0222196]
Depression (also known as major depression or major depressive disorder) is a psychiatric disorder that affects mood, behavior, and overall health. It causes prolonged feelings of sadness, emptiness, or hopelessness, and a loss of interest in activities that were once enjoyed. People with depression may also have changes in appetite (leading to overeating or not eating enough), changes in sleeping patterns (sleeping too much or not being able to sleep), loss of energy, and difficulty concentrating. [Genetics Home Reference, Depression; 2019.02.06]
