FB2024_03 , released June 25, 2024
Human Disease Model Report: cognitive disorders, diet-induced
Open Close
General Information
Name
cognitive disorders, diet-induced
FlyBase ID
FBhh0001296
Disease Ontology Term
Parent Disease
OMIM
Overview

Diets high in hydrogenated vegetable fat induce depression-like and anxiety-like phenotypes in Drosophila adults; increased aggressive activities are also observed. A diet high in saturated fat induces depression-like phenotypes, but not behaviors associated with anxiety or increased aggressive behaviors. With both types of diets, significant drops in serotonin and octopamine are observed.

Male-male aggression has been assessed in adults that developed on a low-, medium- or high-resource diet, manipulated via yeast content. Animals raised on the resource-poor diet exhibited reduced levels of male-male aggressive behaviors.

[updated Mar. 2022 by FlyBase; FBrf0222196]

Disease Summary Information
Disease Summary: cognitive disorders, diet-induced
OMIM report
Human gene(s) implicated
Symptoms and phenotype
Genetics
Cellular phenotype and pathology
Molecular information
External links
    Disease synonyms
    anxiety-like behaviors, diet-induced
    cognitive disorders, high-fat diets
    depression-like behaviors, diet-induced
    Ortholog Information
    Human gene(s) in FlyBase
      Other mammalian ortholog(s) used
        D. melanogaster Gene Information (0)
        Other Genes Used: Viral, Bacterial, Synthetic (0)
          Summary of Physical Interactions (0 groups)
          Alleles Reported to Model Human Disease (Disease Ontology) (0 alleles)
          Alleles Representing Disease-Implicated Variants
          Genetic Tools, Stocks and Reagents
          Sources of Stocks
          Contact lab of origin for a reagent not available from a public stock center.
          Bloomington Stock Center Disease Page
          Related mammalian, viral, bacterial, or synthetic transgenes
          Allele
          Transgene
          Publicly Available Stocks
          Selected Drosophila transgenes
          Allele
          Transgene
          Publicly Available Stocks
          RNAi constructs available
          Allele
          Transgene
          Publicly Available Stocks
          Selected Drosophila classical alleles
          Allele
          Allele class
          Mutagen
          Publicly Available Stocks
          References (6)