Mutations in a number of Drosophila genes produce phenotypes of seizure sensitivity, including zyd. Dmel\zyd encodes a transmembrane transporter that acts as a potassium-dependent sodium/calcium exchanger and is expressed in CNS glial cells. There are multiple orthologous genes in human, including SLC24A3, SLC24A4, SLC24A5 and SLC24A5. To date, none of the orthologous SLC24A human genes has been reported by OMIM as implicated in a seizure- or epilepsy-related disorder.
None of the orthologous SLC24A human genes has been introduced into flies.
Temperature-sensitive loss-of-function mutations in Dmel\zyd result in seizure-sensitivity in adults; at the restrictive temperature, rapid, unpatterned firing is observed at the larval neuromuscular junction. RNAi-effected loss-of-function of Dmel\zyd in glia, but not neurons, results in the seizure-sensitive phenotype. The role of zyd appears to be acute, rather than developmental.
[updated Nov. 2019 by FlyBase; FBrf0222196]
Genes of solute carrier family 24 encode trans-plasma-membrane transporters that act as potassium-dependent sodium/calcium exchangers; they are an important component of intracellular calcium homeostasis and electrical conduction.
[Gene Cards, SLC24A3; 2019.11.04]
Many to many: multiple orthologous genes in both species.
Many to many: multiple orthologous genes in both species.
Many to many: multiple orthologous genes in both species.
Many to many: multiple orthologous genes in both species.
Low- to moderate-scoring ortholog of human SLC24A3, SLC24A4, SLC24A5 and SLC24A5 (multiple orthologous genes in both species). Dmel\zyd shares 38-39% identity and 55-56% similarity with SLC24A3 and SLC24A3, the most closely related human orthologs.
