FlyBase Gene Report: Dmel\zyd

General Information

Symbol

Dmel\zyd

Species

D. melanogaster

Name

zydeco

Annotation Symbol

CG2893

Feature Type

protein_coding_gene

FlyBase ID

FBgn0265767

Gene Model Status

Current

Stock Availability

5 publicly available

Gene Summary

zydeco (zyd) encodes a potassium-dependent sodium/calcium exchanger found in cortex glia. It is thought to serve as a key calcium export pathway to control calcium oscillations that occur in membrane microdomains of the glial cell. [Date last reviewed: 2019-03-21] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

20F4-20F4

Sequence location

X:23,022,898..23,035,550 [+]

Recombination map

1-66

RefSeq locus

NC_004354 REGION:23022898..23035550

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

NCBI

UCSC

Ensembl

Function

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables calcium channel activity

inferred from biological aspect of ancestor with PANTHER:PTN000090975

(GO Reference Genome Project, 2011-)

enables calcium, potassium:sodium antiporter activity

inferred from biological aspect of ancestor with PANTHER:PTN000090975

(GO Reference Genome Project, 2011-)

Biological Process (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in calcium ion transmembrane transport

inferred from mutant phenotype

(Melom and Littleton, 2013)

involved_in calcium-mediated signaling

inferred from mutant phenotype

(Melom and Littleton, 2013)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in calcium ion transmembrane transport

inferred from biological aspect of ancestor with PANTHER:PTN000090975

(GO Reference Genome Project, 2011-)

involved_in intracellular calcium ion homeostasis

inferred from biological aspect of ancestor with PANTHER:PTN000090975

(GO Reference Genome Project, 2011-)

involved_in transmembrane transport

inferred from electronic annotation with InterPro:IPR004837

(InterPro Project Members, 2004-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in plasma membrane

inferred from direct assay

(Melom and Littleton, 2013)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in membrane

inferred from electronic annotation with InterPro:IPR004837

(InterPro Project Members, 2004-)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000090975

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

SLC24 FAMILY OF POTASSIUM-DEPENDENT SODIUM/CALCIUM EXCHANGERS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

SLC24 FAMILY OF POTASSIUM-DEPENDENT SODIUM/CALCIUM EXCHANGERS -: Solute carrier family 24 (SLC24) transmembrane transporters are potassium-dependent sodium/calcium exchangers, which use both the inward sodium gradient and the outward potassium gradient to release calcium. (Adapted from FBrf0111900).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\zyd for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q5LJX8)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.50

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 6.04

Sequence Ontology: Class of Gene

gene

(FlyBase, 1992-)

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

zyd-RA

FBtr0113768

NM_001015262

2172

526

zyd-RD

FBtr0113769

NM_001015263

2460

463

zyd-RE

FBtr0301132

NM_001015260

2006

535

zyd-RF

FBtr0301133

NM_001015261

2094

542

zyd-RG

FBtr0340198

NM_001300714

3164

499

zyd-RH

FBtr0340199

NM_001300715

2341

463

zyd-RI

FBtr0347557

NM_001316629

2794

463

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

zyd-PA

FBpp0112491

56.5

526

6.60

FBpp0112492

49.5

463

7.28

FBpp0290355

57.5

535

5.67

FBpp0290356

58.4

542

7.08

FBpp0309173

53.6

499

5.41

FBpp0309174

49.5

463

7.28

FBpp0312590

49.5

463

7.28

Q5LJX7

NP_001303558

ALI51163

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

463 aa isoforms: zyd-PD, zyd-PH, zyd-PI

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\zyd using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.76

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

ventral midline of embryo

(Wheeler et al., 2009)

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

embryonic/larval cell body glial cell

(Melom and Littleton, 2013)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

embryonic/larval cell body glial cell

(Melom and Littleton, 2013)

Subcellular Localization

CV Term

Evidence

References

located_in plasma membrane

inferred from direct assay

(Melom and Littleton, 2013)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\zyd in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\zyd

View exonic expression by tissue for Dmel\zyd

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0265767

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

3354992/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0265767

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0040030

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0265767

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG2893

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 5 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 3 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of zyd

Transgenic constructs containing regulatory region of zyd

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal - majority die, with Scer\GAL4^repo

viable

viable, with Scer\GAL4^Mef2.PR

zyd^GD3723

viable, with Scer\GAL4^pnr-MD237

zyd^GD3723

Other Phenotypes

Allele

abnormal behavior | adult stage | recessive | heat sensitive

abnormal behavior | heat sensitive, with Scer\GAL4^NP577

abnormal behavior | heat sensitive, with Scer\GAL4^NP2222

abnormal behavior | heat sensitive, with Scer\GAL4^nrv2.PS

abnormal behavior | third instar larval stage | heat sensitive

zyd¹

abnormal behavior | third instar larval stage | heat sensitive, with Scer\GAL4^NP1243

abnormal neurophysiology | third instar larval stage | heat sensitive

zyd¹

abnormal neurophysiology | third instar larval stage | heat sensitive, with Scer\GAL4^repo

bang sensitive

zyd¹

bang sensitive (with zyd¹)

bang sensitive (with zyd²)

zyd¹

bang sensitive (with zyd³)

zyd¹

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (9)

Hsap\SLC24A3

12 of 14

Yes

Hsap\SLC24A4

11 of 14

Yes

5 of 14

4 of 14

4 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (9)

Rnor\Slc24a3

11 of 14

Yes

Rnor\Slc24a4

10 of 14

Yes

5 of 14

4 of 14

3 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (9)

Mmus\Slc24a3

11 of 14

Yes

Mmus\Slc24a4

11 of 14

Yes

5 of 14

4 of 14

4 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (13)

Xtro\slc24a4

7 of 13

Yes

Xtro\cyp2a6.1

6 of 13

Xtro\inhbc.1

6 of 13

Xtro\slc24a3

6 of 13

Yes

4 of 13

3 of 13

2 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (20)

Drer\slc24a3

14 of 14

Yes

Drer\LOC101886560

13 of 14

Yes

Drer\slc24a4a

13 of 14

Yes

Drer\slc24a4b

13 of 14

Yes

Drer\slc24a6a

13 of 14

Yes

5 of 14

4 of 14

3 of 14

1 of 14

Yes

Drer\cax2

1 of 14

Yes

Drer\LOC571043

1 of 14

Yes

Drer\LOC100332770

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (10)

Cele\ncx-5

4 of 14

Yes

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (10)

Agam\AgaP_AGAP010975

7 of 12

Yes

Agam\AgaP_AGAP010977

6 of 12

Yes

Agam\AgaP_AGAP010976

5 of 12

Yes

4 of 12

4 of 12

4 of 12

3 of 12

2 of 12

2 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (12)

Atha\CAX9

4 of 13

Yes

Atha\CAX11

4 of 13

Yes

Atha\CCX4

4 of 13

Yes

Atha\AT5G17850

3 of 13

Atha\CAX7

3 of 13

Atha\CAX1

1 of 13

Yes

Atha\CAX2

1 of 13

Yes

Atha\CAX3

1 of 13

Yes

Atha\CAX4

1 of 13

Yes

Atha\CAX5

1 of 13

Yes

Atha\CAX6

1 of 13

Yes

Atha\MHX

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (4)

Scer\YDL206W

4 of 13

Yes

Scer\ECM27

2 of 13

Scer\VCX1

1 of 13

Yes

Scer\VNX1

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (3)

Spom\SPAC3A12.06c

4 of 12

Yes

Spom\SPAC521.04c

1 of 12

Yes

Spom\vcx1

1 of 12

Yes

Escherichia coli (enterobacterium) (1)

Ecol\yrbG

7 of 11

Yes

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:zyd. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (11)

9 of 13

9 of 13

9 of 13

8 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

seizure-sensitive (postulated), SLC24A-related

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 2 )

Allele

Disease

Evidence

References

zyd¹

model of epilepsy

CEA

(Weiss et al., 2019)

zyd^GD3723

model of epilepsy

CEA

(Weiss et al., 2019)

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

SLC24A4; solute carrier family 24 member 4

model of amelogenesis imperfecta hypomaturation type 2A5

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

zyd¹

model of epilepsy

is ameliorated by CanA-14F^GD14690

(Weiss et al., 2019)

is ameliorated by CanA-14F^HMS01880

(Weiss et al., 2019)

is ameliorated by CanB^GD10703

(Weiss et al., 2019)

is ameliorated by CanB^GD17823

(Weiss et al., 2019)

is ameliorated by CanB^JF02616

(Weiss et al., 2019)

is ameliorated by CanB2^GD13435

(Weiss et al., 2019)

is ameliorated by CanB2^JF02583

(Weiss et al., 2019)

is ameliorated by CanB2^KK107988

(Weiss et al., 2019)

is ameliorated by Rab5^HMS00147

(Weiss et al., 2019)

is ameliorated by Rab5^S43N.UAS

(Weiss et al., 2019)

is ameliorated by Sh^{EKO.UAS.GFP(GL)}

(Weiss et al., 2019)

is ameliorated by cac^KK101478

(Weiss et al., 2019)

is ameliorated by sand^UAS.EGFP

(Weiss et al., 2019)

is ameliorated by CanB2^KO

(Weiss et al., 2019)

is ameliorated by EndoA^GD7681

(Weiss et al., 2019)

is ameliorated by EndoA^JF02758

(Weiss et al., 2019)

is ameliorated by Pp2B-14D^DN.UASp

(Weiss et al., 2019)

is ameliorated by shi^ts.UAS.cUa

(Weiss et al., 2019)

is ameliorated by Pp2B-14D^HMS02039

(Weiss et al., 2019)

is ameliorated by Pp2B-14D^JF01949

(Weiss et al., 2019)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

SLC24A3; solute carrier family 24 member 3

12 of 14

609839

SLC24A4; solute carrier family 24 member 4

11 of 14

609840

amelogenesis imperfecta hypomaturation type 2A5

SLC24A5; solute carrier family 24 member 5

5 of 14

609802

ALBINISM, OCULOCUTANEOUS, TYPE VI; OCA6

oculocutaneous albinism type VI

SLC24A1; solute carrier family 24 member 1

4 of 14

603617

NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 1D; CSNB1D

congenital stationary night blindness 1D

SLC24A2; solute carrier family 24 member 2

4 of 14

609838

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

MIST Molecular Interaction Search Tool

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

zyd

suppressible

Cam

(Melom and Littleton, 2013)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0265767

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Sodium/Calcium exchangers

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-66

Cytogenetic map

20F4-20F4

Sequence location

X:23,022,898..23,035,550 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

20F4-20F4

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

20E-20E

h27

(Drosophila Heterochromatin Genome Project, 2004)

Experimentally Determined Recombination Data

Location

1-66

(FlyBase, 2016)

1-66.3

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (5)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

25851

y¹ v¹; P{TRiP.JF01872}attP2

61128

y¹ w^* Mi{MIC}zyd^MI15679/FM7h

97168

y¹ w^* TI{CRIMIC.TG4.1}zyd^{CR70403-TG4.1}/FM7h

VDRC

v40987

w¹¹¹⁸; P{GD3723}v40987

v40988

w¹¹¹⁸; P{GD3723}v40988

Genomic Clones (4)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (12)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0265767

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Melom and Littleton, 2013)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

zyd is required for microdomain cortex glial Ca[2+] oscillatory activity, and mutation of zyd predisposes animals to seizures in response to several environmental stressors.

(Melom and Littleton, 2013)

Transiently named CG40147 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Identification: cDNA screen for secreted and transmembrane proteins expressed during embryogenesis.

(Kopczynski et al., 1998)

Relationship to Other Genes

Source for database merge of

Source for merge of: CG2893 BEST:CK02262

(FlyBase, 1996-)

Source for merge of: zydeco CG2893

(Melom and Littleton, 2013)

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

BEST:CK02262

CG2893

(Han et al., 2017, Bernstein et al., 2016, Hosono et al., 2015, Ashwal-Fluss et al., 2014, Meadows, 2014.12.12, Melom and Littleton, 2013, Tsubouchi et al., 2012, Vujatovic et al., 2012, Perkins et al., 2009.1.15, Wheeler et al., 2009, Beckervordersandforth et al., 2008, Drosophila Heterochromatin Genome Project, 2007, Altenhein et al., 2006)

CG40147

(Giot et al., 2003)

CK02262

(Kopczynski et al., 1998)

Nckx-x

(Featherstone, 2011)

Ncxk-x

(Winkfein et al., 2004)

zyd

(Lones and DiAntonio, 2023, Sebastian et al., 2022, Weiss et al., 2022, Xie et al., 2022, Bittern et al., 2021, Hope et al., 2020, Weiss et al., 2019, Croset et al., 2018, Gene Disruption Project members, 2018-, Zwarts et al., 2015, Melom and Littleton, 2013)

zydeco

(Guan et al., 2011, Guan et al., 2005)

Name Synonyms

zydeco

(Han et al., 2017, Melom and Littleton, 2013, Guan et al., 2011, Guan et al., 2005)

Secondary FlyBase IDs

FBgn0243503
FBgn0025689
FBgn0058147
FBan0002893
FBgn0040030

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 52 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

3354992

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q5LJX8

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q5LJX8

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0265767

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

3354992/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0265767

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0265767

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG2893

MARRVEL_MODEL - MARRVEL (model organism gene)

3354992

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0265767

DroID - A comprehensive database of gene and protein interactions.

FBgn0265767

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0040030

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0265767

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG2893

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0265767

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC014488

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Sodium/Calcium exchangers

References (53)

The following external sites may use different assemblies or annotations than FlyBase.

-0.76

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