FlyBase Allele Report: Scer\GAL4[NP2222]

General Information

Symbol

Scer\GAL4^NP2222

Species

S. cerevisiae

Name

FlyBase ID

FBal0260979

Feature type

allele

Associated gene

Scer\GAL4

Associated Insertion(s)

P{GawB}Akap200^NP2222

Carried in Construct

Also Known As

NP2222-GAL4, NP2222

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Associated Insertion(s)

P{GawB}Akap200^NP2222

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{GawB}

enhancer trap

Encoded product / tool

GAL4

binary expression system - driver

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:8,420,528..8,420,801

(Haynes et al., 2024, Miao et al., 2024, Li et al., 2023, Li et al., 2023, Shu et al., 2023, Chen et al., 2022, de Torres-Jurado et al., 2022, Weiss et al., 2022, Coll-Tané et al., 2021, Dong et al., 2021, Lee et al., 2021, Lin et al., 2021, Marr and Potter, 2021, Park et al., 2021, Ryabova et al., 2021, Winkler et al., 2021, Chakravarti Dilley et al., 2020, Kim et al., 2020, Nandakumar et al., 2020, Deng et al., 2019, Lee et al., 2019, Nakano et al., 2019, Sengupta et al., 2019, Wang et al., 2019, Weiss et al., 2019, Artiushin et al., 2018, Delgado et al., 2018, Kanai et al., 2018, Kunduri et al., 2018, Yeh et al., 2018, Aw et al., 2017, Coutinho-Budd et al., 2017, Long and Giebultowicz, 2017, Winfree et al., 2017, Dutta et al., 2016, Gai et al., 2016, Kis et al., 2015, Schulz et al., 2015, Stratoulias and Heino, 2015, Stratoulias and Heino, 2015, Rusan et al., 2014, Spéder and Brand, 2014, Awasaki et al., 2011, Ng et al., 2011, Awasaki et al., 2008)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

distribution deduced from reporter (Gal4 UAS)

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

larval ventral nerve cord

(Coutinho-Budd et al., 2017)

larval ventral nerve cord | restricted

(Coutinho-Budd et al., 2017)

embryonic/larval cell body glial cell

(Coutinho-Budd et al., 2017, Spéder and Brand, 2014)

adult stage

adult brain cell body glial cell

(Lee et al., 2019, Melom and Littleton, 2013)

Additional Information

Statement

Reference

Drives expression in adult cell body glial cells (cortex glia).

(FlyBase Curators, 2017)

Marker for

adult brain cell body glial cell

(Melom and Littleton, 2013)

Reflects expression of

Akap200

(Melom and Littleton, 2013)

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal behavior | heat sensitive, with zyd^GD3723

(Melom and Littleton, 2013)

abnormal behavior | heat sensitive, with zyd^JF01872

(Melom and Littleton, 2013)

abnormal cell polarity | larval stage, with htl^λ.UAS

(Dong et al., 2021)

abnormal locomotor behavior | adult stage, with Pvf2^d02444

(Winkler et al., 2021)

abnormal locomotor behavior | adult stage, with sws^HMJ23229

(Ryabova et al., 2021)

abnormal neuroanatomy | adult stage | progressive, with sws^HMJ23229

(Ryabova et al., 2021)

abnormal neuroanatomy | larval stage, with hh^GD6242

(Dong et al., 2021)

abnormal neuroanatomy | larval stage, with htl^λ.UAS

(Dong et al., 2021)

abnormal neuroanatomy | larval stage, with sws^HMJ23229

(Ryabova et al., 2021)

abnormal neurophysiology | adult stage | heat sensitive, with TrpA1^UAS.(B).cKa

(Melom and Littleton, 2013)

abnormal neurophysiology | third instar larval stage | heat sensitive, with TrpA1^UAS.(B).cKa

(Melom and Littleton, 2013)

chemical resistant | adult stage, with CtsL1^GD5803

(Lee et al., 2019)

chemical sensitive | adult stage, with CtsL1^GD5803

(Lee et al., 2019)

chemical sensitive | adult stage, with CtsL1^HMS00725

(Lee et al., 2019)

decreased cell number | larval stage, with hh^GD6242

(Dong et al., 2021)

decreased occurrence of cell division | larval stage, with hh^GD6242

(Dong et al., 2021)

decreased occurrence of cell division | larval stage, with hh^{N.UAS.cHa.EGFP}

(Dong et al., 2021)

decreased occurrence of cell division | larval stage, with hh^UAS.cIa

(Dong et al., 2021)

decreased occurrence of cell division | larval stage, with htl^λ.UAS

(Dong et al., 2021)

decreased size | larval stage, with hh^GD6242

(Dong et al., 2021)

increased cell number, with Pvf2^d02444

(Winkler et al., 2021)

increased cell number | larval stage, with htl^λ.UAS

(Dong et al., 2021)

short lived, with Pvf2^d02444

(Winkler et al., 2021)

Phenotype Manifest In

adult brain, with sws^HMJ23229

(Ryabova et al., 2021)

adult wrapping glial cell, with sws^HMJ23229

(Ryabova et al., 2021)

brain | larval stage, with hh^GD6242

(Dong et al., 2021)

central nervous system, with Pvf2^d02444

(Winkler et al., 2021)

CNS glial cell | decreased number | larval stage, with hh^GD6242

(Dong et al., 2021)

CNS glial cell | increased number | larval stage, with htl^λ.UAS

(Dong et al., 2021)

embryonic/larval wrapping glial cell | larval stage, with sws^HMJ23229

(Ryabova et al., 2021)

neuroblast | larval stage, with hh^GD6242

(Dong et al., 2021)

neuroblast | larval stage, with hh^{N.UAS.cHa.EGFP}

(Dong et al., 2021)

neuroblast | larval stage, with hh^UAS.cIa

(Dong et al., 2021)

neuroblast | larval stage, with htl^λ.UAS

(Dong et al., 2021)

plasmatocyte | increased number, with Pvf2^d02444

(Winkler et al., 2021)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^NP2222, hh^{N.UAS.cHa.EGFP} has decreased occurrence of cell division | larval stage phenotype, suppressible by FASN1^NIG.3523R, Scer\GAL4^NP2222

(Dong et al., 2021)

Scer\GAL4^NP2222, hh^UAS.cIa has decreased occurrence of cell division | larval stage phenotype, suppressible by Lsd-2^HMS00629, Scer\GAL4^NP2222

(Dong et al., 2021)

Scer\GAL4^NP2222, htl^λ.UAS has abnormal neuroanatomy | larval stage phenotype, suppressible | partially by hh^JF01804/Scer\GAL4^NP2222

(Dong et al., 2021)

Scer\GAL4^NP2222, htl^λ.UAS has abnormal neuroanatomy | larval stage phenotype, suppressible | partially by hh^GD6242/Scer\GAL4^NP2222

(Dong et al., 2021)

Scer\GAL4^NP2222, htl^λ.UAS has decreased occurrence of cell division | larval stage phenotype, suppressible | partially by hh^JF01804/Scer\GAL4^NP2222

(Dong et al., 2021)

Scer\GAL4^NP2222, htl^λ.UAS has decreased occurrence of cell division | larval stage phenotype, suppressible | partially by hh^GD6242/Scer\GAL4^NP2222

(Dong et al., 2021)

Scer\GAL4^NP2222, htl^λ.UAS has decreased occurrence of cell division | larval stage phenotype, suppressible by FASN1^NIG.3523R, Scer\GAL4^NP2222

(Dong et al., 2021)

Scer\GAL4^NP2222, htl^λ.UAS has decreased occurrence of cell division | larval stage phenotype, suppressible by Lsd-2^KK111306, Scer\GAL4^NP2222

(Dong et al., 2021)

Scer\GAL4^NP2222, htl^λ.UAS has decreased occurrence of cell division | larval stage phenotype, suppressible | partially by rasp^NIG.11495R/Scer\GAL4^NP2222

(Dong et al., 2021)

Scer\GAL4^NP2222, htl^λ.UAS has decreased occurrence of cell division | larval stage phenotype, suppressible | partially by Scer\GAL4^repo/Lsd-2^HMS00629

(Dong et al., 2021)

Scer\GAL4^NP2222, htl^λ.UAS has decreased occurrence of cell division | larval stage phenotype, suppressible | partially by Cat^UAS.cAa, Scer\GAL4^NP2222

(Dong et al., 2021)

Scer\GAL4^NP2222, htl^λ.UAS has decreased occurrence of cell division | larval stage phenotype, suppressible | partially by Sod1^UAS.cAa/Scer\GAL4^NP2222

(Dong et al., 2021)

Scer\GAL4^NP2222, hh^UAS.cIa has decreased occurrence of cell division | larval stage phenotype, suppressible by Lsd-2^HMS01292, Scer\GAL4^NP2222

(Dong et al., 2021)

Suppressor of

Statement

Reference

FASN1^NIG.3523R, Scer\GAL4^NP2222 is a suppressor of decreased occurrence of cell division | larval stage phenotype of Scer\GAL4^NP2222, hh^{N.UAS.cHa.EGFP}

(Dong et al., 2021)

Lsd-2^HMS00629, Scer\GAL4^NP2222 is a suppressor of decreased occurrence of cell division | larval stage phenotype of Scer\GAL4^NP2222, hh^UAS.cIa

(Dong et al., 2021)

hh^JF01804/Scer\GAL4^NP2222 is a suppressor | partially of abnormal neuroanatomy | larval stage phenotype of Scer\GAL4^NP2222, htl^λ.UAS

(Dong et al., 2021)

hh^GD6242/Scer\GAL4^NP2222 is a suppressor | partially of abnormal neuroanatomy | larval stage phenotype of Scer\GAL4^NP2222, htl^λ.UAS

(Dong et al., 2021)

hh^JF01804/Scer\GAL4^NP2222 is a suppressor | partially of decreased occurrence of cell division | larval stage phenotype of Scer\GAL4^NP2222, htl^λ.UAS

(Dong et al., 2021)

hh^GD6242/Scer\GAL4^NP2222 is a suppressor | partially of decreased occurrence of cell division | larval stage phenotype of Scer\GAL4^NP2222, htl^λ.UAS

(Dong et al., 2021)

FASN1^NIG.3523R, Scer\GAL4^NP2222 is a suppressor of decreased occurrence of cell division | larval stage phenotype of Scer\GAL4^NP2222, htl^λ.UAS

(Dong et al., 2021)

Lsd-2^KK111306, Scer\GAL4^NP2222 is a suppressor of decreased occurrence of cell division | larval stage phenotype of Scer\GAL4^NP2222, htl^λ.UAS

(Dong et al., 2021)

rasp^NIG.11495R/Scer\GAL4^NP2222 is a suppressor | partially of decreased occurrence of cell division | larval stage phenotype of Scer\GAL4^NP2222, htl^λ.UAS

(Dong et al., 2021)

Cat^UAS.cAa, Scer\GAL4^NP2222 is a suppressor | partially of decreased occurrence of cell division | larval stage phenotype of Scer\GAL4^NP2222, htl^λ.UAS

(Dong et al., 2021)

Sod1^UAS.cAa/Scer\GAL4^NP2222 is a suppressor | partially of decreased occurrence of cell division | larval stage phenotype of Scer\GAL4^NP2222, htl^λ.UAS

(Dong et al., 2021)

Lsd-2^HMS01292, Scer\GAL4^NP2222 is a suppressor of decreased occurrence of cell division | larval stage phenotype of Scer\GAL4^NP2222, hh^UAS.cIa

(Dong et al., 2021)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^NP2222, hh^{N.UAS.cHa.EGFP} has neuroblast | larval stage phenotype, suppressible by FASN1^NIG.3523R, Scer\GAL4^NP2222

(Dong et al., 2021)

Scer\GAL4^NP2222, htl^λ.UAS has neuroblast | larval stage phenotype, suppressible | partially by hh^GD6242/Scer\GAL4^NP2222

(Dong et al., 2021)

Scer\GAL4^NP2222, htl^λ.UAS has neuroblast | larval stage phenotype, suppressible | partially by hh^JF01804/Scer\GAL4^NP2222

(Dong et al., 2021)

Scer\GAL4^NP2222, htl^λ.UAS has neuroblast | larval stage phenotype, suppressible | partially by FASN1^NIG.3523R, Scer\GAL4^NP2222

(Dong et al., 2021)

Scer\GAL4^NP2222, htl^λ.UAS has neuroblast | larval stage phenotype, suppressible by Lsd-2^KK111306, Scer\GAL4^NP2222

(Dong et al., 2021)

Scer\GAL4^NP2222, htl^λ.UAS has neuroblast | larval stage phenotype, suppressible | partially by rasp^NIG.11495R/Scer\GAL4^NP2222

(Dong et al., 2021)

Scer\GAL4^NP2222, hh^UAS.cIa has neuroblast | larval stage phenotype, suppressible by Lsd-2^HMS01292, Scer\GAL4^NP2222

(Dong et al., 2021)

Scer\GAL4^NP2222, htl^λ.UAS has neuroblast | larval stage phenotype, suppressible | partially by Sod1^UAS.cAa/Scer\GAL4^NP2222

(Dong et al., 2021)

Scer\GAL4^NP2222, htl^λ.UAS has neuroblast | larval stage phenotype, suppressible | partially by Cat^UAS.cAa, Scer\GAL4^NP2222

(Dong et al., 2021)

Scer\GAL4^NP2222, hh^UAS.cIa has neuroblast | larval stage phenotype, suppressible by Lsd-2^HMS00629, Scer\GAL4^NP2222

(Dong et al., 2021)

Suppressor of

Statement

Reference

FASN1^NIG.3523R, Scer\GAL4^NP2222 is a suppressor of neuroblast | larval stage phenotype of Scer\GAL4^NP2222, hh^{N.UAS.cHa.EGFP}

(Dong et al., 2021)

hh^GD6242/Scer\GAL4^NP2222 is a suppressor | partially of neuroblast | larval stage phenotype of Scer\GAL4^NP2222, htl^λ.UAS

(Dong et al., 2021)

hh^JF01804/Scer\GAL4^NP2222 is a suppressor | partially of neuroblast | larval stage phenotype of Scer\GAL4^NP2222, htl^λ.UAS

(Dong et al., 2021)

FASN1^NIG.3523R, Scer\GAL4^NP2222 is a suppressor | partially of neuroblast | larval stage phenotype of Scer\GAL4^NP2222, htl^λ.UAS

(Dong et al., 2021)

Lsd-2^KK111306, Scer\GAL4^NP2222 is a suppressor of neuroblast | larval stage phenotype of Scer\GAL4^NP2222, htl^λ.UAS

(Dong et al., 2021)

rasp^NIG.11495R/Scer\GAL4^NP2222 is a suppressor | partially of neuroblast | larval stage phenotype of Scer\GAL4^NP2222, htl^λ.UAS

(Dong et al., 2021)

Sod1^UAS.cAa/Scer\GAL4^NP2222 is a suppressor | partially of neuroblast | larval stage phenotype of Scer\GAL4^NP2222, htl^λ.UAS

(Dong et al., 2021)

Cat^UAS.cAa, Scer\GAL4^NP2222 is a suppressor | partially of neuroblast | larval stage phenotype of Scer\GAL4^NP2222, htl^λ.UAS

(Dong et al., 2021)

Lsd-2^HMS01292, Scer\GAL4^NP2222 is a suppressor of neuroblast | larval stage phenotype of Scer\GAL4^NP2222, hh^UAS.cIa

(Dong et al., 2021)

Lsd-2^HMS00629, Scer\GAL4^NP2222 is a suppressor of neuroblast | larval stage phenotype of Scer\GAL4^NP2222, hh^UAS.cIa

(Dong et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Scer\GAL4^NP2222/Cpes^UAS.cKa rescues Cpes^KO

(Kunduri et al., 2018)

CPT2^UAS.cSa/Scer\GAL4^NP2222 rescues CPT2^δ3

(Schulz et al., 2015)

zyd^UAS.cMa/Scer\GAL4^NP2222 rescues zyd¹

(Melom and Littleton, 2013)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Kyoto

112830

w^*; P{GawB}Akap200^NP2222 / CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Scer\GAL4^{Akap200-NP2222}

Scer\GAL4^NP2222

Name Synonyms

Secondary FlyBase IDs

References (49)

Report Sections

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