Human Disease Model Report: cancer, epithelial, SCRIB-LATS1,2-related

General Information

Name

cancer, epithelial, SCRIB-LATS1,2-related

FlyBase ID

FBhh0001436

Disease Ontology Term

carcinoma

Parent Disease

OMIM

Overview

This model of epithelial cancer uses the Drosophila Scribble polarity complex gene scrib in combination with a member of the Hippo signaling pathway, the Drosophila gene wts. The highly conserved Scribble polarity complex plays a key role in determining cell polarity and cell proliferation in epithelial cells. See also 'cancer, epithelial, SCRIB-related' (FBhh0000587), 'cancer, multiple, Hippo signaling pathway' (FBhh0000764), and the 'Hippo Signaling Pathway' report (FBgg0000917).

The orthologous human genes, Hsap\SCRIB, Hsap\LATS1, and Hsap\LATS2, have been introduced into flies, but have not been used for this disease model. Heterologous rescue (functional complementation) has been demonstrated in all three cases.

The scrib-wts model uses clones generated by mitotic recombination in developing wing discs; clones of scrib[-] wts[-] homozygous double mutant cells develop into large tumors. This system has been used to characterize regulation of JAK/STAT activity in the prothoracic gland by extrinsic factors such as tumors and tissue damage.

[updated Feb. 2022 by FlyBase; FBrf0222196]

Disease Summary Information

Disease Summary: cancer, epithelial, SCRIB-LATS1,2-related

OMIM report

Human gene(s) implicated

Symptoms and phenotype

Genetics

Cellular phenotype and pathology

Molecular information

LATS1 and LATS2 encode serine/threonine protein kinases belonging to the LATS tumor suppressor family; they act as negative regulators of the Hippo signaling pathway. [Gene Cards, LATS1, LATS2; 2022.02.20]

(FlyBase Curators, 2013-)

The SCRIB gene encodes a scaffold protein involved in cell polarization processes; it is involved in tumor suppression pathways. [Gene Cards, SCRIB; 2022.02.20]

(FlyBase Curators, 2013-)

External links

COSMIC gene: SCRIB
COSMIC gene: LATS1
COSMIC gene: LATS2
Gene2Function (human gene): SCRIB
Gene2Function (human gene): LATS1
Gene2Function (human gene): LATS2
Gene Cards: SCRIB
Gene Cards: LATS1
Gene Cards: LATS2
MedlinePlus (gene): SCRIB
MedlinePlus (gene): LATS2
MedlinePlus (gene): LATS1
KEGG Disease Pathways: Pathways in Cancer
MARRVEL (human gene): SCRIB
MARRVEL (human gene): LATS1
MARRVEL (human gene): LATS2
NCBI (Entrez) gene: SCRIB; scribble planar cell polarity protein
NCBI (Entrez) gene: LATS2; large tumor suppressor kinase 2
NCBI (Entrez) gene: LATS1; large tumor suppressor kinase 1

Disease synonyms

Related Diseases

Related human health report(s)

cancer, epithelial, SCRIB-related

cancer, multiple, Hippo signaling pathway

Ortholog Information

Human gene(s) in FlyBase

Human gene (HGNC)

Symbol / Name

SCRIB; scribble planar cell polarity protein

D. melanogaster ortholog (based on DIOPT)

Dmel\scrib

(DIOPT, 2013-)

Comments on ortholog(s)

Many to one: 2 human genes to 1 Drosophila gene; the second human gene is LRRC1.

Human gene (HGNC)

Symbol / Name

LATS1; large tumor suppressor kinase 1

D. melanogaster ortholog (based on DIOPT)

Dmel\wts

(DIOPT, 2013-)

Comments on ortholog(s)

Many to one: 2 human genes to 1 Drosophila gene.

Human gene (HGNC)

Symbol / Name

LATS2; large tumor suppressor kinase 2

D. melanogaster ortholog (based on DIOPT)

Dmel\wts

(DIOPT, 2013-)

Comments on ortholog(s)

Many to one: 2 human genes to 1 Drosophila gene.

Other mammalian ortholog(s) used

D. melanogaster Gene Information (2)

Dmel\wts

Gene Snapshot

warts (wts) encodes a tumor suppressor kinase in the Hippo pathway involved in the control of tissue growth. It also plays a post-mitotic role in R8 photoreceptor cells where it antagonizes the product of melt to control the bistable choice of Rhodospin expression. [Date last reviewed: 2019-03-21]

Molecular function (GO)

Cellular component (GO)

Gene Groups / Pathways

AGC-U
SWH-C

Comments on ortholog(s)

Moderate-scoring ortholog of human LATS1 and LATS2 (1 Drosophila to 2 human); Dmel\wts shares 38-42% identity and 47-50% similarity with the human genes.

Orthologs and Alignments from DRSC

DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans

H. sapiens (Human)

Dmel\scrib

Gene Snapshot

scribble (scrib) encodes a scaffolding protein that is part of the conserved machinery regulating apicobasal polarity. It acts with the products of dlg1 and l(2)gl to distinguish the basolateral domain of epithelial cells and neuroblasts, via reciprocally antagonistic interactions with the aPKC/par-6 complex that impacts vesicle trafficking. The product of scrib also organizes synaptic architecture and is implicated in learning and memory. [Date last reviewed: 2019-03-14]

Molecular function (GO)

Cellular component (GO)

Gene Groups / Pathways

SCRIBC

Comments on ortholog(s)

Ortholog of human SCRIB and LRRC1 (1 Drosophila to 2 human); Dmel\scrib shares 33% identity and 45% similarity with the human SCRIB gene. The human LRRC1 gene encodes a much smaller protein, corresponding to the amino end of SCRIB and Dmel\scrib; it shares 57% identity and 73% similarity with Dmel\scrib within that extent.

Orthologs and Alignments from DRSC

DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans

H. sapiens (Human)

Other Genes Used: Viral, Bacterial, Synthetic (0)

Summary of Physical Interactions (61 groups)

wts

protein-protein

Interacting group

Assay

References

wts - Ars2

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

wts - baz

coimmunoprecipitation, anti tag western blot

(Keder et al., 2015)

wts - CCT6

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

wts - CG11999

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

wts - Csk

enzymatic study, western blot

(Stewart et al., 2003)

wts - CtsL1

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

wts - Cul4

proximity ligation assay, fluorescence microscopy

(Ly et al., 2019)

wts - dachs

anti tag coimmunoprecipitation, anti tag western blot

(Rauskolb et al., 2011, Cho et al., 2006)

wts - Dbct

anti tag coimmunoprecipitation, anti tag western blot, peptide massfingerprinting

(Kwon et al., 2013, Kwon et al., 2013)

wts - esc

anti tag coimmunoprecipitation, anti tag western blot

(Parrish et al., 2007)

wts - ex

anti tag coimmunoprecipitation, anti tag western blot, western blot

(Sun et al., 2015)

wts - hpo

anti tag coimmunoprecipitation, anti tag western blot, enzymatic study, western blot, autoradiography

(Li et al., 2015, Zheng et al., 2015, Yin et al., 2013, Oh et al., 2009, Emoto et al., 2006, Jia et al., 2003, Pantalacci et al., 2003, Wu et al., 2003)

wts - hppy

enzymatic study, western blot

(Zheng et al., 2015)

wts - insc

coimmunoprecipitation, anti tag western blot

(Keder et al., 2015)

wts - jar

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

wts - jub

anti tag coimmunoprecipitation, anti tag western blot, western blot

(Rauskolb et al., 2022, Alégot et al., 2019, Rauskolb et al., 2014, Reddy and Irvine, 2013)

wts - kibra

anti tag coimmunoprecipitation, anti tag western blot

(Tokamov et al., 2021)

wts - Klp61F

anti tag coimmunoprecipitation, peptide massfingerprinting, anti tag western blot

(Kwon et al., 2013, Kwon et al., 2013)

wts - lic

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

wts - lola

anti tag coimmunoprecipitation, anti tag western blot

(Hao et al., 2020)

wts - lost

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

wts - LysRS

anti tag coimmunoprecipitation, peptide massfingerprinting, anti tag western blot

(Kwon et al., 2013, Kwon et al., 2013)

wts - mahj

anti tag coimmunoprecipitation, anti tag western blot, proximity ligation assay, fluorescence microscopy

(Ly et al., 2019)

wts - mats

enzymatic study, western blot, anti tag coimmunoprecipitation, anti tag western blot, peptide massfingerprinting, two hybrid, pull down

(Ding et al., 2021, Kwon et al., 2013, Yin et al., 2013, Ho et al., 2010, Wei et al., 2007, He et al., 2005, Lai et al., 2005)

wts - Mcad

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

wts - Mer

anti tag coimmunoprecipitation, anti tag western blot

(Yin et al., 2013)

wts - mnb

enzymatic study, autoradiography, anti tag coimmunoprecipitation, anti tag western blot, peptide massfingerprinting

(Degoutin et al., 2013)

wts - Mob2

two hybrid

(He et al., 2005)

wts - msn

anti tag coimmunoprecipitation, anti tag western blot, enzymatic study, western blot

(Li et al., 2018, Li et al., 2014)

wts - Mtpα

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

wts - Myo61F

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

wts - Pc

anti tag coimmunoprecipitation, anti tag western blot

(Parrish et al., 2007)

wts - pch2

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

wts - PH4αEFB

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

wts - pic

anti tag coimmunoprecipitation, anti tag western blot, proximity ligation assay, fluorescence microscopy

(Ly et al., 2019)

wts - Rab5

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

wts - sav

pull down, anti tag western blot

(Tapon et al., 2002)

wts - sd

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

wts - SERCA

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

wts - slmb

anti tag coimmunoprecipitation, anti tag western blot

(Tokamov et al., 2021)

wts - Smurf

anti tag coimmunoprecipitation, anti tag western blot

(Hu et al., 2017, Cao et al., 2014)

wts - Src42A

anti tag coimmunoprecipitation, anti tag western blot

(Ding et al., 2021)

wts - wap

anti bait coimmunoprecipitation, anti tag western blot

(Degoutin et al., 2013)

wts - yki

anti tag coimmunoprecipitation, anti tag western blot, pull down, peptide massfingerprinting, enzymatic study, western blot, autoradiography, two hybrid

(Zhao et al., 2023, Srivastava et al., 2021, Hao et al., 2020, Hu et al., 2016, Hu et al., 2014, Kwon et al., 2013, Sansores-Garcia et al., 2013, Badouel et al., 2009, Oh et al., 2009, Zhang et al., 2009, Wu et al., 2008, Dong et al., 2007, Huang et al., 2005)

wts - Zyx

anti tag coimmunoprecipitation, anti tag western blot

(Rauskolb et al., 2011)

scrib

protein-protein

Interacting group

Assay

References

scrib

anti tag coimmunoprecipitation, anti tag western blot

(Gui et al., 2016)

scrib - α-Cat

anti tag coimmunoprecipitation, anti tag western blot

(Huang et al., 2023)

scrib - bark

proximity ligation assay, fluorescence microscopy

(Sharifkhodaei et al., 2019)

scrib - dlg1

colocalization, fluorescence microscopy, inferred by author, anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation, proximity-dependent biotin identification, proximity ligation assay

(Sharp et al., 2021, Ventura et al., 2020, Nakajima et al., 2019, Sharifkhodaei et al., 2019, Rui et al., 2017, Mathew et al., 2002)

scrib - Gli

proximity ligation assay, fluorescence microscopy

(Sharifkhodaei et al., 2019)

scrib - gukh

anti bait coimmunoprecipitation, western blot, isothermal titration calorimetry, predetermined participant, x-ray crystallography

(Caria et al., 2018, Mathew et al., 2002)

scrib - Mad

anti tag coimmunoprecipitation, anti tag western blot

(Gui et al., 2016)

scrib - Nrx-1

anti tag coimmunoprecipitation, western blot, pull down

(Rui et al., 2017)

scrib - Pak

anti tag coimmunoprecipitation, western blot

(Bahri et al., 2010)

scrib - Pak3

anti tag coimmunoprecipitation, western blot

(Cervantes-Sandoval et al., 2016, Bahri et al., 2010)

scrib - Rab5

anti tag coimmunoprecipitation, anti tag western blot

(Gui et al., 2016)

scrib - Rac1

anti tag coimmunoprecipitation, western blot

(Cervantes-Sandoval et al., 2016)

scrib - tkv

anti tag coimmunoprecipitation, anti tag western blot

(Gui et al., 2016)

scrib - Traf4

pull down, autoradiography

(Mathew et al., 2011)

scrib - tsr

anti tag coimmunoprecipitation, western blot

(Cervantes-Sandoval et al., 2016)

scrib - Vang

pull down, autoradiography, two hybrid, anti tag coimmunoprecipitation, anti tag western blot

(Humphries et al., 2023, Courbard et al., 2009)

Alleles Reported to Model Human Disease (Disease Ontology) (31 alleles)

wts

Models Based on Experimental Evidence ( 7 )

Allele

Disease

Evidence

References

wts^100Aa-1

model of cancer

CEA

(Xu et al., 1995)

wts^100Aa-4

model of cancer

CEA

(Xu et al., 1995)

wts^P2

model of cancer

CEA

(Justice et al., 1995)

wts^P8

model of carcinoma

CEC

(Tao et al., 1999)

wts^e26-1

model of benign neoplasm

CEA

(de Vreede et al., 2018)

model of carcinoma

CEC

(Tao et al., 1999)

wts^x1

model of neurodegenerative disease

CEA

(Napoletano et al., 2011)

model of cancer

CEA with mei-41^unspecified

(Busygina et al., 2004)

CEA

(Yang et al., 2022, Xu et al., 1995)

model of kidney cancer

CEA

(Zeng et al., 2010)

wts^KK101055

model of cancer

CEA

(Liu et al., 2022, Yang et al., 2022, Guo et al., 2020)

CEA with pnut^GD1512

(Gerlach et al., 2018)

model of brain cancer

CEA with Ras85D^V12.cUa.UAS

(Manzanero-Ortiz et al., 2021)

Modifiers Based on Experimental Evidence ( 10 )

Allele

Disease

Interaction

References

wts^P8

model of carcinoma

is ameliorated by Cdk1^B47

(Tao et al., 1999)

wts^{UAS.L.Tag:MYC}

ameliorates cancer

modeled by shot^GL01286

(Jain et al., 2019)

wts^e26-1

model of carcinoma

is ameliorated by Cdk1^B47

(Tao et al., 1999)

is ameliorated by Cdk1^E1-24

(Tao et al., 1999)

is ameliorated by Hsap\LATS1^hs.PT

(Tao et al., 1999)

wts^x1

ameliorates autism spectrum disorder

modeled by Abca3^GD3708

(Ueoka et al., 2020)

exacerbates cancer

modeled by ex^AP49

(Hamaratoglu et al., 2006)

model of cancer

is ameliorated by Ire1^UAS.Tag:V5

(Yang et al., 2022)

is ameliorated by Xbp1^UAS.s.Tag:V5

(Yang et al., 2022)

wts^GD1563

exacerbates high grade glioma

modeled by Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, btl::Egfr^λ.UAS

(Vigneswaran et al., 2021)

wts^KK101055

exacerbates high grade glioma

modeled by Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, btl::Egfr^λ.UAS

(Vigneswaran et al., 2021)

model of cancer

is ameliorated by Ire1^UAS.Tag:V5

(Yang et al., 2022)

is ameliorated by Hsc70-3^{UAS.ORF.Tag:HA}

(Yang et al., 2022)

is ameliorated by Xbp1^UAS.s.Tag:V5

(Yang et al., 2022)

is ameliorated by Rox8^EY02351

(Guo et al., 2020)

wts^G4808

ameliorates dentatorubral-pallidoluysian atrophy

modeled by Gug^75QN.UAS

(Napoletano et al., 2011)

wts^UAS.cUa

ameliorates cancer

modeled by Ptp61F^Δ, Ras85D^V12.cUa.UAS

(Liu et al., 2022)

exacerbates Alzheimer's disease 1

modeled by Hsap\APP^{Aβ42.UAS.cUa}

(Irwin et al., 2020)

ameliorates carcinoma

modeled by Ras85D^V12.UAS, msn³²⁰⁸

(Kong et al., 2021)

wts^RNAi.UAS.cUa

exacerbates cancer

modeled by scrib^GD11666

(Ding et al., 2021)

wts^TRiP.cUa

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^{Aβ42.UAS.cUa}

(Irwin et al., 2020)

scrib

Models Based on Experimental Evidence ( 10 )

Allele

Disease

Evidence

References

scrib^KK101128

model of cancer

CEA

(Tamori et al., 2016)

CEA with Stat92E^{ΔNΔC.UASp.Tag:HA}, RhoGEF2^HMS01118

(Tamori et al., 2016)

CEA with Ras85D^V12.UAS

(Muzzopappa et al., 2017)

model of leukemia

CEA with Ras85D^V12.UAS

(Arefin et al., 2017)

model of carcinoma

CEA with Ras85D^V12.UAS

(Murcia et al., 2019)

scrib^j7B3

model of cancer

CEA with Hsap\SCRIB^UAS.EGFP

(Dow et al., 2003)

CEA with Ras85D^V12.UAS

(Pagliarini and Xu, 2003)

scrib^GD11663

model of carcinoma

CEA

(Wu et al., 2021)

model of cancer

CEA

(Yang et al., 2022)

scrib⁶⁷³

model of carcinoma

CEA with scrib¹

(de Vreede et al., 2022)

CEA

(de Vreede et al., 2022, Brumby and Richardson, 2003, Bilder et al., 2000)

CEA with Ras85D^V12.UAS

(Amcheslavsky et al., 2018)

model of brain cancer

CEA with Ras85D^V12.cUa.UAS

(Manzanero-Ortiz et al., 2021)

model of cancer

CEA with Egfr^2.A887T.UAS

(Sheng and Du, 2020)

scrib^GD11666

model of cancer

CEA

(Ding et al., 2021)

model of carcinoma

CEA

(Ding et al., 2022, Sun et al., 2019, Zhang et al., 2019)

scrib¹

model of carcinoma

CEA

(Zheng et al., 2023, Kong et al., 2022, Kong et al., 2021, Parvy et al., 2019, Katsukawa et al., 2018, O'Keefe et al., 2015, Igaki et al., 2009, Uhlirova et al., 2005, Brumby and Richardson, 2003, Bilder et al., 2000)

CEA with scrib⁶⁷³

(de Vreede et al., 2022)

CEA with Ras85D^V12.UAS

(Kong et al., 2021, Mishra-Gorur et al., 2019, Srivastava et al., 2007, Igaki et al., 2006, Uhlirova and Bohmann, 2006)

CEA with Raf^UAS.F179

(Wei et al., 2021, Uhlirova et al., 2005)

CEA with egr¹

(Igaki et al., 2009)

CEA with Rab5^S43N.UAS

(Igaki et al., 2009)

model of cancer

CEA with Ras85D^V12.UAS

(Cong et al., 2021, Hodgson et al., 2021, Külshammer et al., 2015, Külshammer and Uhlirova, 2013, Willoughby et al., 2013, Wu et al., 2010, Pagliarini and Xu, 2003)

CEA with cno^R2

(Rives-Quinto et al., 2017)

CEA

(Sanaki et al., 2020, Bunker et al., 2015, Ohsawa et al., 2011)

CEA with rl^R80S.UAS

(Kushnir et al., 2020)

CEA with rl^{D334N.UAS.cKa}

(Kushnir et al., 2020)

CEA with rl^{R80S.D334N.UAS}

(Kushnir et al., 2020)

CEA with Ras85D^V12.QUAS.cHa

(Hodgson et al., 2021)

CEA with Ras85D^V12.cUa.UAS

(Yang et al., 2022, Khezri et al., 2021)

CEA with Raf^UAS.F179

(Yang et al., 2022)

model of benign neoplasm

CEA

(de Vreede et al., 2018)

model of kidney cancer

CEA

(Zeng et al., 2010)

scrib^HMS01490

model of cancer

CEA

(Bunker et al., 2015)

model of carcinoma

CEA

(Yadav and Srikrishna, 2019)

scrib^HMJ21977

model of carcinoma

CEA with yki^{S111A.S168A.S250A.UAS.Tag:V5}

(Snigdha et al., 2021)

CEA with Ras85D^V12.UAS

(Snigdha et al., 2021)

CEA

(Snigdha et al., 2021)

scrib^RNAi.UAS.cUa

model of carcinoma

CEA

(Song et al., 2023, Xu et al., 2022)

model of cancer

CEA with Ras85D^V12.UAS

(Hodgson et al., 2021)

scrib^{QUAS.HMS01490}

model of cancer

CEA with Ras85D^V12.QUAS.cLa

(Bakopoulos et al., 2023, Lodge et al., 2021)

Modifiers Based on Experimental Evidence ( 11 )

Allele

Disease

Interaction

References

scrib^KK101128

model of cancer

is exacerbated by Stat92E^{ΔNΔC.UASp.Tag:HA}

(Tamori et al., 2016)

scrib^j7B3

ameliorates viral infectious disease

modeled by EBV\BRLF1^GMR.PA

(Adamson and Lajeunesse, 2012)

ameliorates infectious mononucleosis

modeled by EBV\BRLF1^GMR.PA

(Adamson and Lajeunesse, 2012)

ameliorates Epstein-Barr virus hepatitis

modeled by EBV\BRLF1^GMR.PA

(Adamson and Lajeunesse, 2012)

scrib^GD11663

model of carcinoma

is ameliorated by CtBP^HMS00677

(Wu et al., 2021)

is ameliorated by CtBP^JF01291

(Wu et al., 2021)

is ameliorated by puc^UAS.cMa

(Wu et al., 2021)

model of cancer

is ameliorated by Ire1^UAS.Tag:V5

(Yang et al., 2022)

is ameliorated by Xbp1^UAS.s.Tag:V5

(Yang et al., 2022)

scrib⁶⁷³

exacerbates brain cancer

modeled by Ras85D^V12.cUa.UAS, dlg1^GD4689

(Manzanero-Ortiz et al., 2021)

modeled by Ras85D^V12.cUa.UAS, l(2)gl^KK100777

(Manzanero-Ortiz et al., 2021)

modeled by Ras85D^V12.cUa.UAS, wts^KK101055

(Manzanero-Ortiz et al., 2021)

scrib^GD11666

model of cancer

is exacerbated by hpo^RNAi.UAS.cUa

(Ding et al., 2021)

is exacerbated by wts^RNAi.UAS.cUa

(Ding et al., 2021)

is ameliorated by yki^RNAi.UAS.cUa

(Ding et al., 2021)

model of carcinoma

is ameliorated by lic^GD7546

(Sun et al., 2019)

is ameliorated by lic^JF01433

(Sun et al., 2019)

is ameliorated by pan^JF02306

(Zhang et al., 2019)

is ameliorated by wg^GD5007

(Zhang et al., 2019)

is exacerbated by Toll-7^{C993Y.UAS.Tag:FLAG}

(Ding et al., 2022)

is ameliorated by Toll-7^GD14417

(Ding et al., 2022)

is ameliorated by Toll-7^HM05230

(Ding et al., 2022)

scrib¹

model of carcinoma

is exacerbated by α-Spec^HMC04371

(Kong et al., 2022)

is exacerbated by Rho1^72F

(Kong et al., 2022)

is exacerbated by Rok^GD1522

(Kong et al., 2022)

is exacerbated by Toll-6^GD14438

(Kong et al., 2022)

is exacerbated by Toll-6^GD35

(Kong et al., 2022)

is exacerbated by kst^GLC01654

(Kong et al., 2022)

is exacerbated by sqh^GL00663

(Kong et al., 2022)

is exacerbated by zip^GD1566

(Kong et al., 2022)

is exacerbated by BacA\p35^UAS.cHa

(Zheng et al., 2023, Brumby and Richardson, 2003)

is ameliorated by Dad^UAS.cTa

(Brumby and Richardson, 2003)

is ameliorated by Egfr^DN.UAS

(Brumby and Richardson, 2003)

is exacerbated by N^ICN.UAS

(Brumby and Richardson, 2003)

is exacerbated by Ras85D^V12.UAS

(Brumby and Richardson, 2003)

is exacerbated by bsk^K53R.UAS

(Uhlirova et al., 2005, Brumby and Richardson, 2003)

is ameliorated by pan^ΔN.UAS

(Brumby and Richardson, 2003)

is ameliorated by Wwox^KK108459

(O'Keefe et al., 2015)

is exacerbated by Dif^LA00958

(Katsukawa et al., 2018)

is ameliorated by Spn88Ea^GD12724

(Katsukawa et al., 2018)

is ameliorated by Spn88Ea^HMS01371

(Katsukawa et al., 2018)

is ameliorated by Spn88Ea^c01214

(Katsukawa et al., 2018)

is ameliorated by Spn88Ea^eld5

(Katsukawa et al., 2018)

is exacerbated by Tl^10b.UAS

(Katsukawa et al., 2018)

is exacerbated by dl^UAS.cHa

(Katsukawa et al., 2018)

is ameliorated by hep^Act.UAS

(Uhlirova et al., 2005)

is ameliorated by kay^RNAi.UAS

(Uhlirova and Bohmann, 2006)

is ameliorated by puc^UAS.cMa

(Uhlirova and Bohmann, 2006)

is exacerbated by Def^SK3

(Parvy et al., 2019)

is exacerbated by egr³

(Parvy et al., 2019)

is exacerbated by bsk^DN.UAS.cUa

(Kong et al., 2021)

is ameliorated by msn^UAS.cSa

(Kong et al., 2021)

is ameliorated by Diap1^UAS.cHa

(Zheng et al., 2023)

is ameliorated by Dronc^DN.UAS.cUa

(Zheng et al., 2023)

is ameliorated by Ire1^GD3071

(Zheng et al., 2023)

is ameliorated by Ire1^f02170

(Zheng et al., 2023)

is ameliorated by Xbp1^GD4745

(Zheng et al., 2023)

is ameliorated by Xbp1^UAS.s.Tag:V5

(Zheng et al., 2023)

is exacerbated by bsk^DN.UAS

(Zheng et al., 2023)

is ameliorated by HAdV-C\E4orf4^UAS.cPa

(Rosen et al., 2019)

is ameliorated by HAdV-C\E4orf4^UAS.cPb

(Rosen et al., 2019)

model of cancer

is ameliorated by hep^r75

(Bunker et al., 2015)

is ameliorated by yki^B5

(Bunker et al., 2015)

is ameliorated by egr¹

(Ohsawa et al., 2011)

is ameliorated by Ilp2¹

(Sanaki et al., 2020)

is exacerbated by Ilp2^UAS.cBa

(Sanaki et al., 2020)

is ameliorated by Ilp5³

(Sanaki et al., 2020)

is ameliorated by InR^K1409A.UAS

(Sanaki et al., 2020)

is exacerbated by InR^UAS.Exel

(Sanaki et al., 2020)

is exacerbated by chico¹

(Sanaki et al., 2020)

is exacerbated by chico^KK107581

(Sanaki et al., 2020)

scrib^HMS01490

model of cancer

is ameliorated by dome^ΔCYT.UAS

(Bunker et al., 2015)

is ameliorated by Socs36E^UASp.cCa

(Bunker et al., 2015)

model of carcinoma

is exacerbated by park^JF01200

(Yadav and Srikrishna, 2019)

is ameliorated by park^{UAS.Tag:FLAG,Tag:Mito(hCOX4I1)}

(Yadav and Srikrishna, 2019)

scrib^HMJ21977

model of carcinoma

is ameliorated by wgn^GLC01716

(Snigdha et al., 2021)

scrib^UASp.cRa

exacerbates tauopathy

modeled by Hsap\MAPT^UAS.cWa

(Feuillette et al., 2020)

scrib^RNAi.UAS.cUa

model of carcinoma

is exacerbated by apt^GD1367

(Song et al., 2023)

is ameliorated by apt^UAS.cEa

(Song et al., 2023)

is ameliorated by Gadd45^KK104250

(Xu et al., 2022)

is ameliorated by Glyat^TH00482

(Xu et al., 2022)

is ameliorated by Glyat^c02982

(Xu et al., 2022)

is ameliorated by Gadd45^HMS01436

(Xu et al., 2022)

scrib^UAS.GFP

ameliorates autism spectrum disorder

modeled by Nrx-1²⁷³

(Rui et al., 2017)

Hsap\SCRIB

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

Hsap\SCRIB^UAS.EGFP

model of cancer

CEA with scrib^j7B3

(Dow et al., 2003)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Hsap\LATS1

Models Based on Experimental Evidence ( 2 )

Allele

Disease

Evidence

References

Hsap\LATS1^V719I.UAS

model of organ system benign neoplasm

CEA

(Yu et al., 2013)

Hsap\LATS1^R806P.UAS

model of organ system benign neoplasm

CEA

(Yu et al., 2013)

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

Hsap\LATS1^hs.PT

ameliorates carcinoma

modeled by wts^e26-1

(Tao et al., 1999)

Hsap\LATS2

Models Based on Experimental Evidence ( 2 )

Allele

Disease

Evidence

References

Hsap\LATS2^G909R.UAS

model of organ system benign neoplasm

CEA

(Yu et al., 2013)

Hsap\LATS2^C953.UAS

model of organ system benign neoplasm

CEA

(Yu et al., 2013)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Alleles Representing Disease-Implicated Variants

Genetic Tools, Stocks and Reagents

Sources of Stocks

Contact lab of origin for a reagent not available from a public stock center.

Bloomington Stock Center Disease Page

Related mammalian, viral, bacterial, or synthetic transgenes

Allele

Transgene

Publicly Available Stocks

w^*; P{UAS-EGFP-hScrib}T3

Selected Drosophila transgenes

Allele

Transgene

Publicly Available Stocks

wts^{UAS.L.Tag:MYC}

P{UAS-wts.L.MYC}

w^*; P{UAS-wts.L.MYC}2/CyO, P{Dfd-EYFP.w^BmC}2

w^*; P{UASp-scrib.R}B10

RNAi constructs available

Allele

Transgene

Publicly Available Stocks

w¹¹¹⁸; P{GD1563}v9928

y¹ v¹; P{TRiP.JF02741}attP2

y¹ v¹; P{TRiP.HMS00026}attP2

wts^GL01331

P{TRiP.GL01331}

y¹ sc^* v¹ sev²¹; P{TRiP.GL01331}attP2

scrib^{QUAS.HMS01490}

PBac{QUAS-HMS01490}

scrib^{RNAi.13xlexAop.cZa}

P{13xlexAop-scrib.RNAi.Z}

scrib^GD11666

P{GD11666}

w¹¹¹⁸ P{GD11666}v27430

y¹ v¹; P{TRiP.JF03229}attP2

scrib^HMS01490

P{TRiP.HMS01490}

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01490}attP2

y¹ sc^* v¹ sev²¹; P{TRiP.GL00638}attP40

scrib^HMS01993

P{TRiP.HMS01993}

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01993}attP40/CyO

y¹ v¹; P{TRiP.HMJ21977}attP40/CyO

scrib^RNAi.UAS

P{UAS-scrib.RNAi}

w^*; P{UAS-scrib.RNAi}7L

Selected Drosophila classical alleles

Allele

Allele class

Mutagen

Publicly Available Stocks

wts^P2

Delta2-3 transposase

wts^P8

Delta2-3 transposase

wts^100Aa-4

loss of function allele

ethyl methanesulfonate

wts^100Aa-6

loss of function allele

ethyl methanesulfonate

wts^100Aa-7

loss of function allele

ethyl methanesulfonate

wts^100Aa-14

loss of function allele

ethyl methanesulfonate

wts^100Aa-9

loss of function allele

ethyl methanesulfonate

wts^100Aa-8

loss of function allele

ethyl methanesulfonate

wts^100Aa-12

loss of function allele

ethyl methanesulfonate

wts^100Aa-5

loss of function allele

ethyl methanesulfonate

wts^100Aa-10

loss of function allele

ethyl methanesulfonate

wts^100Aa-1

amorphic allele - genetic evidence

ethyl methanesulfonate

wts^x1

loss of function allele

w^*; wts^x1 P{neoFRT}82B/TM6B, Tb¹

wts^e26-1

Delta2-3 transposase

y¹ w^*; wts^e26-1/TM6B, Tb⁺

wts^100Aa-11

loss of function allele

ethyl methanesulfonate

wts^100Aa-3

loss of function allele

ethyl methanesulfonate

wts^100Aa-13

loss of function allele

ethyl methanesulfonate

wts^100Aa-15

loss of function allele

ethyl methanesulfonate

wts^100Aa-2

loss of function allele

ethyl methanesulfonate

wts^5Y2

loss of function allele

wts^G4808

P-element activity

w¹¹¹⁸; P{EP}wts^G4808/TM6C, Sb¹

scrib^j7B3

P-element activity

y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{5xglBS-lacZ.38-1}TPN1; P{neoFRT}82B P{lacW}scrib^j7B3/TM6B, P{Car20y}TPN1, Tb¹

scrib^ird15

loss of function allele

ethyl methanesulfonate

scrib¹

loss of function allele

ethyl methanesulfonate

scrib⁶⁷³

loss of function allele

ethyl methanesulfonate

Dp(1;Y)Bar^S; scrib⁶⁷³ e¹/TM3, Ser¹

References (3)

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