FB2024_04 , released June 25, 2024
Human Disease Model Report: high-salt diet, locomotor and cardiac dysfunction
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General Information
Name
high-salt diet, locomotor and cardiac dysfunction
FlyBase ID
FBhh0001443
Disease Ontology Term
Parent Disease
OMIM
Overview

Effects of long-term exposure to a high-salt diet have been investigated in Drosophila. Decreased climbing ability is observed; endurance exercise ameliorates this phenotype. Age-related defects cardiac dysfunction is accelerated under a high-salt dietary regimen; long-term exercise also ameliorates this phenotype. A high-salt diet also has a modest impact on circadian rhythm phenotypes and sleep quality.

Some investigations into effects of high salt make use of mutations in the Drosophila salt gene, which encodes a sodium/solute symporter in the SLC5 family involved in response to salt stress.

[updated Mar. 2022 by FlyBase; FBrf0222196]

Disease Summary Information
Disease Summary: high-salt diet, locomotor and cardiac dysfunction
OMIM report
Human gene(s) implicated
Symptoms and phenotype
Genetics
Cellular phenotype and pathology
Molecular information
External links
    Disease synonyms
    Ortholog Information
    Human gene(s) in FlyBase
      Other mammalian ortholog(s) used
        D. melanogaster Gene Information (1)
        Dmel\salt
        Gene Snapshot
        salty dog (salt) encodes a sodium/solute symporter in the SLC5 family involved in response to salt stress. [Date last reviewed: 2019-03-21]
        Molecular function (GO)
        Cellular component (GO)
        Gene Groups / Pathways
        Comments on ortholog(s)

        Moderate-scoring ortholog of human SLC5A5, SLC5A8 and SLC5A12 (multiple orthologous genes in both species).

        Orthologs and Alignments from DRSC
        DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans
        H. sapiens (Human)
        Other Genes Used: Viral, Bacterial, Synthetic (0)
          Summary of Physical Interactions (0 groups)
          Alleles Reported to Model Human Disease (Disease Ontology) (0 alleles)
          Alleles Representing Disease-Implicated Variants
          Genetic Tools, Stocks and Reagents
          Sources of Stocks
          Contact lab of origin for a reagent not available from a public stock center.
          Bloomington Stock Center Disease Page
          Related mammalian, viral, bacterial, or synthetic transgenes
          Allele
          Transgene
          Publicly Available Stocks
          Selected Drosophila transgenes
          Allele
          Transgene
          Publicly Available Stocks
          RNAi constructs available
          Allele
          Transgene
          Publicly Available Stocks
          saltHMJ22216
          P{TRiP.HMJ22216}
          y1 v1; P{TRiP.HMJ22216}attP40/CyO
          saltGD12732
          P{GD12732}
          w1118; P{GD12732}v28349/TM3
          saltGD574
          P{GD574}
          saltKK113232
          P{KK113232}
          P{KK113232}VIE-260B
          saltRNAi.WIZ.UAS
          P{UAS-salt.RNAi.WIZ}
          saltNIG.2196R
          P{NIG.2196R}
          Selected Drosophila classical alleles
          Allele
          Allele class
          Mutagen
          Publicly Available Stocks
          References (6)