Garcia, A.M., Derventzi, A., Busuttil, R., Calder, R.B., Perez, E., Chadwell, L., Dollé, M.E.T., Lundell, M., Vijg, J. (2007). A model system for analyzing somatic mutations in Drosophila melanogaster. Nat. Methods 4(5): 401--403.
FlyBase ID
FBrf0201074
Publication Type
Research paper
Abstract
Presently there are no good assays for comparing somatic mutation frequencies and spectra between different vertebrate and invertebrate organisms. Here we describe a new lacZ mutation reporter system in D. melanogaster, which complements existing systems in the mouse. The results obtained with the new model indicate two-to threefold higher frequencies of spontaneous mutations than in the mouse, with most of the mutations characterized as large genome rearrangements.
