For each genome release, there are generally a number of changes that affect the total number or type of gene models (annotations) for that annotated genome. A summary of these changes can be found in the "Summary of changes from previous release" section of the relevant genome release on the "Release Notes" page. Specific notes concerning major changes are noted in the appropriate gene records and are attributed to a reference for that genome annotation release. This particular reference is the "FlyBase analysis" reference for release 5.45 of the annotated D.melanogaster genome.