FB2024_02 , released April 23, 2024
Experimental tool: Phobos(CA)
Open Close
General Information
Symbol
Phobos(CA)
FlyBase ID
FBto0000570
Name
Description
Description

Phobos(CA) is an anion-selective channelrhodopsin that can be used as an optogenetic tool to inhibit neuron activity. It was generated by adding the C128A amino acid substitution to Phobos. This mutation slows off kinetics, resulting in Phobos(CA) behaving as a bistable channelrhodopsin; it is activated by a brief pulse of light to produce a prolonged photocurrent with a longer duration than the initiating pulse, resulting in a stable step in membrane potential, and it can be inactivated by a second light pulse of longer wavelength. Peak activation wavelength is 450nm, peak inactivation wavelength is 580nm (FBrf0237123). For detailed kinetic and spectral properties, see FBrf0237123. For a comparison of Phobos(CA) with other neuron inactivation tools, see FBrf0237123.

External Crossreferences and Linkouts
Related experimental tools
Transgenic Constructs
Encodes tool (1)
Transgenic construct(s)
Component allele
Reg. region
Encoded product / tool
Tagged with
Also carries
Stocks
Insertions ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Phobos(CA)
Name Synonyms
Secondary FlyBase IDs
    References (3)