FB2024_03 , released June 25, 2024
Allele: Dmel\αTub84B5
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General Information
Symbol
Dmel\αTub84B5
Species
D. melanogaster
Name
FlyBase ID
FBal0000017
Feature type
allele
Associated gene
Dmel\αTub84B
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

hypomorphic allele - genetic evidence

(Hutchens et al., 1997)
Mutagen
ethyl methanesulfonate
(Hutchens et al., 1997)
Progenitor genotype
Cytology
Description

Amino acid replacement: P348S.

(Blard, 2015.9.9)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:7,088,272..7,088,272 [+]
Nucleotide change:

C7088272T

Amino acid change:

P348S | alphaTub84B-PA

Reported amino acid change:

P348S

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Blard, 2015.9.9)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Transheteroallelic combinations produce males that are sterile or weakly fertile.

      (Hutchens et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      alphaTub84B[+]/αTub84B5 is an enhancer of visible phenotype of Scer\GAL4GMR.PF, bchsEP2299

      (Simonsen et al., 2007)
      Other
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      alphaTub84B[+]/αTub84B5 is an enhancer of eye phenotype of Scer\GAL4GMR.PF, bchsEP2299

      (Simonsen et al., 2007)
      Other
      Statement
      Reference

      αTub84B5, TBCB[+]/Tbcb1 has follicle cell phenotype

      (Baffet et al., 2012)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Flies double heterozygous for αTub84B5 and TBCB1 are viable, but display strongly reduced fertility and follicle cell polarity defects.

      (Baffet et al., 2012)

      Expression of αTub85EβTub85D.PH partially rescues the defective αTub84B function in spermatogenesis: most spermatids have complete axonemes.

      (Hutchens et al., 1997)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      K. Matthews.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Alpha-Tubulin84B5
      (Blard, 2015.9.9)
      α-tubulin 84B5
      (Baffet et al., 2012)
      α-tubulin84B5
      (Simonsen et al., 2007)
      αTub84B5
      (Johns et al., 2018)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)