FB2024_03 , released June 25, 2024
Allele: Dmel\abd-AD24
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General Information
Symbol
Dmel\abd-AD24
Species
D. melanogaster
Name
FlyBase ID
FBal0000080
Feature type
allele
Associated gene
Dmel\abd-A
Associated Insertion(s)
Carried in Construct
Also Known As
iab-2D24, abdAD24
Key Links
Allele class

loss of function allele

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Hopmann et al., 1995, Capovilla et al., 1994)

loss of function allele

(Kurant et al., 1998, Karch et al., 1990, Busturia et al., 1989)
Mutagen
ethyl methanesulfonate
(Karch et al., 1985)
Progenitor genotype
Cytology

Polytene chromosomes normal.

(Karch et al., 1985)
Description

Point mutation.

(Karch et al., 1985)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      lch5 chordotonal organs are frequently mislocalised to the dorsal side of abd-AD24 mutant embryos. These mislocalised chordotonal organs lack ligament attachment cells.

      (Inbal et al., 2004)

      The LCh5 neurons are abnormal in homozygous embryos, and are rarely found in a lateral or dorso-lateral position. The LCh5 neurons exhibit a DCh3-like morphology in abd-AD24 hthdtl-S142204 double mutant embryos and are positioned laterally in 17-19% of abdominal segments.

      (Kurant et al., 1998)

      Cuticle preparations of embryos heterozygous with abd-AD24 show transformations of abdominal segments towards an A1 identity.

      (Hendrickson and Sakonju, 1995)

      Two posterior midgut constrictions fail to form.

      (Mathies et al., 1994)

      First instar larvae exhibit lateral dots (a paired structure found in A1 segment of wild type) in abdominal segment A2 to A5 and rarely in A6.

      (Jijakli and Ghysen, 1992)

      Hemizygous embryonic phenotype displays complete transformation of abdominal parasegments 7, 8 and 9 into parasegment 6 and partial transformation of abdominal parasegments 10 to 13 into parasegment 6 (FBrf0043314).

      (Busturia et al., 1989)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Ubx1, abd-AD24, Abd-BD18 triple mutant embryos show a significantly increased proportion of mitotic neuroblasts in the A9-10 ventral nerve cord segments, and a significantly increased proportion of mitotic neuroblast daughter cells in the A1, A8 and A9-10 ventral nerve cord segments, as compared to controls.

      (Monedero Cobeta et al., 2017)

      Dp(3;2)D109; abd-AD24, Abd-BD18/Df(3R)Ubx-RS4-8 males are phenotypically indistinguishable from Abd-BD18/Df(3R)Ubx-RS4-8 males in abdominal segmentation and show A5 and A6 identities. Dp(3;2)D109; Ubx1, abd-AD24, Abd-BD18/Df(3R)Ubx-RS4-8 males show A5 and A6 identities while Dp(3;2)D109; Df(3R)RS1-98/Df(3R)Ubx-RS4-8 lack A5 and A6 identities.

      (Hopmann et al., 1995)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      Duncan.

      I. Duncan.

      (Karch et al., 1985)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      References (21)