FB2024_03 , released June 25, 2024
Allele: Dmel\Abd-BD18
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General Information
Symbol
Dmel\Abd-BD18
Species
D. melanogaster
Name
FlyBase ID
FBal0044547
Feature type
allele
Associated gene
Dmel\Abd-B
Associated Insertion(s)
Carried in Construct
Also Known As
AbdBD18
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
X ray
(Hopmann et al., 1995)
Progenitor genotype
Abd-BMc
(Hopmann et al., 1995)
Cytology

Polytene chromosomes normal.

(Hopmann et al., 1995)
Description

Deleted for BX-C between +163.5-166.5 and 148.5-150, i.e. breaks fall in both the complete and the duplicated section of Abd-B region. Lacks the 9kb EcoRI fragment diagnostic of Abd-BMc.

(Hopmann et al., 1995)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Abd-BD18 mutant embryos show a significant increase in the number of (Dpn-positive) neuroblasts in the ventral nerve cord segments A9-10, show a significantly increased mitotic index of neuroblasts in the ventral nerve cord segments A9-10 and show significantly increased mitotic index of neuroblast daughter cell in the ventral nerve cord segments A8, as compared to controls.

      (Monedero Cobeta et al., 2017)

      Mutant embryos generate an additional cluster of eve positive mesodermal cells in PS 13. Supernumerary cardioblasts are also seen in the heart portion of the dorsal vessel of late stage embryos: about 116 cardioblast nuclei are seen as opposed to 104 in the wild-type. The heart in these embryos do not appear to be significantly elongated, it is frequently much wider and extra cardioblasts are arranged in irregular clusters or double-rows within its posterior portion. The somatic muscles in abdominal segment 8 in mutant embryos show an increase in the number of nuclei, and a pattern that is more similar to that normally found in A7.

      (Lo et al., 2002)

      Heterozygous flies show no transformation of A7 towards A6. The phenotype of abdominal segment 6 is similar in Abd-BFab7-1/Abd-BD18 and Abd-BFab7-1/+ flies.

      (Sipos et al., 1998)

      Heterozygotes with Df(3R)Ubx-RS4-8 or Df(3R)Abd-BS10 have partial transformation of A5-7 to more anterior character: A7 forms tergite, like A6 in the WT; A6 resembles A5 in having more trichome covered area than WT A6 ; A5, which is fully pigmented in the WT, is, like WT A4, only partially pigmented. Dp(3;2)D109; abd-AD24, Abd-BD18/Df(3R)Ubx-RS4-8 and Dp(3;2)D109; abd-AH10.7, Abd-BD18/Df(3R)Ubx-RS4-8 males are phenotypically indistinguishable from Abd-BD18/Df(3R)Ubx-RS4-8 males in abdominal segmentation and show A5 and A6 identities. Dp(3;2)D109; Ubx1, abd-AD24, Abd-BD18/Df(3R)Ubx-RS4-8 males show A5 and A6 identities while Dp(3;2)D109; Df(3R)RS1-98/Df(3R)Ubx-RS4-8 lack A5 and A6 identities.

      (Hopmann et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT suppressed by
      Statement
      Reference

      Abd-BD18 has visible | recessive | homeotic | somatic clone phenotype, non-suppressible by AntpNs-rvC3

      (Estrada and Sanchez-Herrero, 2001)
      Other
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Ubx1, abd-AD24, Abd-BD18 triple mutant embryos show a significantly increased proportion of mitotic neuroblasts in the A9-10 ventral nerve cord segments, and a significantly increased proportion of mitotic neuroblast daughter cells in the A1, A8 and A9-10 ventral nerve cord segments, as compared to controls.

      (Monedero Cobeta et al., 2017)

      The transformation of genitalia into leg seen in Abd-BD18 mutant clones is still seen in Abd-BD18 AntpNs-rvC3 double mutants.

      (Estrada and Sanchez-Herrero, 2001)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially complements

      Abd-BSz

      (Sipos et al., 1998)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (3)
      Notes on Origin
      Discoverer

      Revertant. Revertant of the Abd-BMc microcephalus phenotype.

      (Hopmann et al., 1995)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      References (20)