FB2024_03 , released June 25, 2024
Allele: Dmel\amd1
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General Information
Symbol
Dmel\amd1
Species
D. melanogaster
Name
FlyBase ID
FBal0000458
Feature type
allele
Associated gene
Dmel\amd
Associated Insertion(s)
Carried in Construct
Also Known As
l(2)amdH1, amdH1
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Wright et al., 1982)
spontaneous
(Wright et al., 1981)
Progenitor genotype
Cytology
Description

The reduced amd gene product interferes with catecholamine metabolism.

(Black et al., 1987)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant embryos exhibit a melanotic ring around the anal organ and at this point they burst by popping the anal organ or by bursting at other locations suggesting a defect in the integrity of the cuticle. The anal organ protrudes from the embryo as the cuticular suture between the anal organ and hypoderm cells is absent.

      (Wang and Marsh, 1995)

      Sensitive to dietary α-methyl dopa.

      (Wright et al., 1982)

      Sensitive to α-methyl dopa.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      amd1/amd11 has partially lethal phenotype, suppressible by Df(3L)TP32

      (Bishop et al., 1999)

      amd1/amd6 has partially lethal phenotype, suppressible by Df(3L)TP32

      (Bishop et al., 1999)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      amd1/amd6 and amd1/amd11 transheterozygotes show partial lethality. These flies show a substantial increase in viability if they are also carrying one copy of Df(3L)TP32.

      (Bishop et al., 1999)

      amd5/amd1 or amd6/amd1 flies show an increase in viability when they are also heterozygous for Tcr40 or Tcr45. amd11/amd1 flies show an increase in viability when they are also heterozygous for Tcr40. Complementation between Tcr40 and Tcr45 is not increased by amd1, but amd1 has a maternal effect on Tcr40/Tcr45 embryos, causing an increase in embryonic mortality.

      (Bishop et al., 1989)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially complements

      amd6

      (Black et al., 1987)
      Rescued by

      amd1 is rescued by amd+t2.9

      (Wang and Marsh, 1995)
      Comments

      Mutant phenotype can be rescued by two copies of amd+t2.9.

      (Wang and Marsh, 1995)

      Half amd1/amd6 heterozygotes survive to eclosion.

      (Black et al., 1987)

      One of alleles of amd for which intragenic complementation has been demonstrated. See also FBrf0026742.

      (Wright et al., 1982)

      Alleles of amd show intracistronic complementation.

      (Wright et al., 1976)
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      Sparrow.

      Sparrow and Wright.

      (Wright et al., 1982)

      Selected as: Dominant α-methyl dopa hypersensitive.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      amd1
      (Roshina and Pasyukova, 2007)
      amdH1
      (Wright, 1996, Wang and Marsh, 1995, Black et al., 1987)
      l(2)amdH1
      (Bishop et al., 1999, Bishop et al., 1989, Wright et al., 1981, Wright et al., 1976)
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0042815
      References (11)