FB2024_03 , released June 25, 2024
Allele: Dmel\amd6
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General Information
Symbol
Dmel\amd6
Species
D. melanogaster
Name
FlyBase ID
FBal0000463
Feature type
allele
Associated gene
Dmel\amd
Associated Insertion(s)
Carried in Construct
Also Known As
l(2)amdH89, amdH89
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Wright et al., 1982)
Progenitor genotype
Cytology
Description

The reduced amd gene product interferes with catecholamine metabolism.

(Black et al., 1987)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      amdH29/amd6 has partially lethal phenotype, suppressible by Tcr45

      (Bishop et al., 1999)

      amd1/amd6 has partially lethal phenotype, suppressible by Df(3L)TP32

      (Bishop et al., 1999)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      amdH29/amd6 transheterozygotes show partial lethality. These flies show a striking increase in viability if they are also carrying one copy of Tcr45. amd1/amd6 transheterozygotes show partial lethality. These flies show a substantial increase in viability if they are also carrying one copy of Df(3L)TP32.

      (Bishop et al., 1999)

      amd6/amd1 flies show an increase in viability when they are also heterozygous for Tcr40 or Tcr45.

      (Bishop et al., 1989)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially complements

      amd1

      (Black et al., 1987)
      Rescued by

      amd6 is rescued by amd+t2.9

      (Wang and Marsh, 1995)
      Comments

      Mutant phenotype can be rescued by two copies of amd+t2.9.

      (Wang and Marsh, 1995)

      Half amd1/amd6 heterozygotes survive to eclosion.

      (Black et al., 1987)

      Alleles of amd show intracistronic complementation.

      (Wright et al., 1976)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Sparrow.

      Sparrow and Wright.

      (Wright et al., 1982)

      Selected as: Dominant α-methyl dopa hypersensitive.

      Comments
      Comments

      See also FBrf0026742.

      (Wright et al., 1982)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      amd6
      (Roshina and Pasyukova, 2007)
      amdH89
      (Wright, 1996, Wright et al., 1976)
      andH89
      (Black et al., 1987)
      l(2)amdH89
      (Bishop et al., 1999, Bishop et al., 1989)
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0042821
      References (10)