FB2024_03 , released June 25, 2024
Allele: Dmel\Tcr45
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General Information
Symbol
Dmel\Tcr45
Species
D. melanogaster
Name
FlyBase ID
FBal0016748
Feature type
allele
Associated gene
Tcr
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Bishop et al., 1989)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Heterozygotes show resistance to dietary α-methyl dopa. 48.3% of Tcr40/Tcr45 individuals die during embryogenesis. These animals live for 48 or more hours after egg deposition but fail to escape from the egg. They appear as mature first instar larvae with an underpigmented cephalopharyngeal apparatus. 7.5% of Tcr40/Tcr45 individuals survive past adult eclosion, but these adults are usually found dead or dying in the food. Adults not found in the food are unable to walk on their tarsi and walk on their metatarsi or tibia with uncoordinated leg movements. Both pharate and eclosed adults have a range of abnormalities, including dark, rough, often reduced eyes with black spots, missing bristles (especially from the head), one to all ocelli missing, notching of the wings, reduced scutellum, Minute-like bristles mixed with wild-type bristles, unexpanded ptilinum, reduced sex combs and a greyish abdomen.

      (Bishop et al., 1989)

      Tcr/+ heterozygotes resistant to dietary α methyl dopa. Homozygous lethal. Heteroallelic combination Tcr40/Tcr45 partially lethal, 48.3% dying as late embryos, these unhatched larvae having underpigmented mouthparts like lethal Ddc/Ddc embryos; only 7.5% go through pupation and manage to eclose, but these adults die soon. Both pharate and hatched adults have cuticular abnormalities involving the eyes (rough, often small, with black, necrotic spots), ocelli (often missing), wings (notched), scutellum (reduced), bristles (missing or M-like), sex combs (reduced) and abdomen (grayish). Tcr/+ heterozygotes suppress the lethality of amd heteroallelic combinations; Tcr heteroallelic combinations are not rescued genetically by amd/+, but show increased embryonic mortality as a maternal effect of amd.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Tcr45 is a suppressor of partially lethal phenotype of amd11/amdH29

      (Bishop et al., 1999)

      Tcr45 is a suppressor of partially lethal phenotype of amdH29/amd6

      (Bishop et al., 1999)
      NOT Suppressor of
      Statement
      Reference

      Tcr45 is a non-suppressor of lethal phenotype of amdH29/amdH23

      (Bishop et al., 1999)

      Tcr45 is a non-suppressor of partially lethal phenotype of Ddc8/Ddc5

      (Bishop et al., 1999)

      Tcr45 is a non-suppressor of partially lethal phenotype of DdcDE1/Ddc5

      (Bishop et al., 1999)

      Tcr45 is a non-suppressor of partially lethal phenotype of DdcDE1/Ddc8

      (Bishop et al., 1999)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      amd5/amd1 or amd6/amd1 flies show an increase in viability when they are also heterozygous for Tcr45. Complementation between Tcr40 and Tcr45 is not increased by amd1 or amdH26, but these amd alleles have a maternal effect on Tcr40/Tcr45 embryos, causing an increase in embryonic mortality.

      (Bishop et al., 1989)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      partially complements Tcr40

      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Tcr45
      Name Synonyms
      Secondary FlyBase IDs
        References (2)