FlyBase Allele Report: Dmel\Antp[Wu]

General Information

Symbol

Dmel\Antp^Wu

Species

D. melanogaster

Name

FlyBase ID

FBal0000619

Feature type

allele

Associated gene

Dmel\Antp

Associated Insertion(s)

Carried in Construct

Also Known As

Antp^W

Key Links

Allele class

Mutagen

gamma ray

Nature of the Allele

Allele class

Mutagen

gamma ray

(Scott et al., 1983)

Progenitor genotype

Caused by aberration

In(3LR)Antp^Wu

Cytology

Description

The 3R inversion breakpoint is at map position +152-158.

(Scott et al., 1983)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | dominant

(Abbott and Kaufman, 1986)

lethal | recessive

(Scott et al., 1983)

lethal - all die before end of larval stage

(Jorgensen and Garber, 1987)

some die during larval stage

(Jorgensen and Garber, 1987)

visible | dominant | homeotic

(Jorgensen and Garber, 1987)

visible | homeotic

(Abbott and Kaufman, 1986)

Phenotype Manifest In

antenna

(Cribbs et al., 1995, Jorgensen and Garber, 1987, Abbott and Kaufman, 1986, Scott et al., 1983)

mesothoracic leg | ectopic

(Cribbs et al., 1995)

Detailed Description

Statement

Reference

Heterozygous individuals have antennae transformed into second thoracic legs.

(Jorgensen and Garber, 1987)

Homeotic transformation of antennae to mesothoracic legs.

(Abbott and Kaufman, 1986)

Antennae to leg transformation.

(Scott et al., 1983)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Antp^Wu, ct^L188 has visible phenotype

(Johnston et al., 1998)

Antp^Wu, ct^C145 has visible phenotype

(Johnston et al., 1998)

Phenotype Manifest In

Other

Statement

Reference

Antp^Wu, ct^L188 has humeral bristle phenotype

(Johnston et al., 1998)

Antp^Wu, ct^L188 has humerus phenotype

(Johnston et al., 1998)

Antp^Wu, ct^L188 has dorsal prothorax phenotype

(Johnston et al., 1998)

Antp^Wu, ct^C145 has humeral bristle phenotype

(Johnston et al., 1998)

Antp^Wu, ct^C145 has humerus phenotype

(Johnston et al., 1998)

Antp^Wu, ct^C145 has dorsal prothorax phenotype

(Johnston et al., 1998)

Antp^Wu, pb^hs.PB has antenna phenotype

(Cribbs et al., 1995)

Antp^Wu, pb^hs.PB has maxillary palp | ectopic phenotype

(Cribbs et al., 1995)

Additional Comments

Genetic Interactions

Statement

Reference

In heterozygous combination with ct^L188 or ct^C145, ectopic structures project (usually unilaterally) from the position of the anterior spiracle on the dorsal prothorax, and are associated with malformation of absence of the two macrochaetaes on the humeral callus. The phenotype is incompletely penetrant and not as severe as for Antp¹¹.

(Johnston et al., 1998)

Homeotic transformation of antennae to T2 leg seen in Antp^Wu flies can be redirected by pb^hs.PB from ectopic leg to maxillary palp.

(Cribbs et al., 1995)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Wu.

Comments

Strong dominant allele.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Antp^W

(Jorgensen and Garber, 1987, Abbott and Kaufman, 1986)

Antp^WU

(Cummins et al., 2003)

Antp^Wu

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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