FlyBase Allele Report: Dmel\bi[1]

General Information

Symbol

Dmel\bi¹

Species

D. melanogaster

Name

FlyBase ID

FBal0001119

Feature type

allele

Associated gene

Dmel\bi

Associated Insertion(s)

Carried in Construct

Also Known As

bifid, omb^bi, bi

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

spontaneous

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Shen et al., 2008, Grimm and Pflugfelder, 1996, Craymer and Roy, 1980)

Mutagen

spontaneous

Progenitor genotype

Cytology

Description

An insertion in the first intron of bi.

(Shen et al., 2008)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | recessive

(Shen et al., 2008)

partially lethal - majority die (with bi¹²)

(Sen et al., 2010)

partially lethal - majority die (with bi¹³)

(Sen et al., 2010)

partially lethal - majority die (with bi¹⁵)

(Sen et al., 2010)

viable

(Pflugfelder et al., 1992)

visible | dominant

(Craymer and Roy, 1980)

visible | recessive

(Grimm and Pflugfelder, 1996)

visible | recessive | heat sensitive

(Shen et al., 2008)

Phenotype Manifest In

wing

(Shen et al., 2008, Grimm and Pflugfelder, 1996, Craymer and Roy, 1980)

wing (with bi¹²)

(Sen et al., 2010)

wing (with bi¹³)

(Sen et al., 2010)

wing (with bi¹⁵)

(Sen et al., 2010)

wing disc

(Shen et al., 2008)

wing disc (with bi^D4)

(Shen et al., 2008)

wing hinge | heat sensitive

(Shen et al., 2008)

wing pouch

(Shen et al., 2008)

wing pouch (with bi^D4)

(Shen et al., 2008)

wing pouch | heat sensitive

(Shen et al., 2008)

wing sensillum | ectopic

(Shen et al., 2008)

wing vein

(Grimm and Pflugfelder, 1996, Craymer and Roy, 1980)

wing vein (with bi¹²)

(Sen et al., 2010)

wing vein (with bi¹³)

(Sen et al., 2010)

wing vein (with bi¹⁵)

(Sen et al., 2010)

wing vein | heat sensitive

(Shen et al., 2008)

wing vein L3

wing vein L4

Detailed Description

Statement

Reference

In bi¹ hemizygotes, the proximal longitudinal veins in the hinge region are fused into a bifid stalk.The 'bifid' vein-fusion phenotype is temperature-dependent, overlapping with wild-type at 18[o]C and (in males) reaches full penetrance at 25[o]C. Wing size of bi¹ hemizygotes is slightly reduced compared to wild type. At least one large ectopic bristle is observed with high penetrance on the ventral side of the distal tip of vein L3 in bi¹ adult wings.

bi¹ mutant wings exhibit an ectopic furow along the A/P boundary at 25[o]C. This furrow is more pronounced in the strongly hypomorphic bi¹/bi^D4 transheterozygote. Overgrowth also occurs in the anterior ventral pleura region of the wing disc.

(Shen et al., 2008)

Proximal fusion of all longitudinal veins and variable defects at the tip of the wing. These defects become more severe over null mutations and are dominantly enhanced by mutations in ap and dpp.

(Grimm and Pflugfelder, 1996)

Hemizygotes have outspread, crumpled, and very flimsy wings with an extreme bi fusion of the basal regions of the longitudinal wing veins.

(Craymer and Roy, 1980)

Longitudinal veins fused at base of wing into bifid stalk. L3 delta-like at tip; L4 often incomplete at tip. Wing margins often excised at tip of L4. Wings spread in proportion to their shortness. RK1.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

bi¹ has visible phenotype, enhanceable by dpp^d8

(Grimm and Pflugfelder, 1996)

bi¹ has visible phenotype, enhanceable by ap^56f

(Grimm and Pflugfelder, 1996)

Phenotype Manifest In

Enhanced by

Statement

Reference

bi¹ has wing phenotype, enhanceable by dpp^d8

(Grimm and Pflugfelder, 1996)

bi¹ has wing phenotype, enhanceable by ap^56f

(Grimm and Pflugfelder, 1996)

Enhancer of

Statement

Reference

bi¹ is an enhancer of phenotype of sd^unspecified

(Bridges and Brehme, 1944)

bi¹ is an enhancer of phenotype of vg^np

(Bridges and Brehme, 1944)

bi¹ is an enhancer of phenotype of cp^unspecified

(Bridges and Brehme, 1944)

bi¹ is an enhancer of phenotype of Bx^unspecified

(Bridges and Brehme, 1944)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

bi^Qd

(Banga et al., 1986)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

bi¹ ct⁶ g²/C(1)DX, y¹ f¹

Kyoto

105674

bi¹ ct⁶ g²

Notes on Origin

Discoverer

Comments

High temperature enhances the phenotype and low temperature produces overlapping of wild type. Expression stronger in male than in female.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

(Pflugfelder and Heisenberg, 1995, Pflugfelder et al., 1992, Pflugfelder et al., 1990)

bi¹

(Christensen et al., 2008.6.11, Christensen et al., 2008.9.3, Christensen et al., 2008.12.28, Christensen et al., 2008.12.28)

omb^bi

(Sen et al., 2010, Shen et al., 2008, Grimm and Pflugfelder, 1996)

Name Synonyms

bifid

(Grimm and Pflugfelder, 1996, Pflugfelder and Heisenberg, 1995, Pflugfelder et al., 1992, Pflugfelder et al., 1990)

ombbifid

(Shen et al., 2008)

Secondary FlyBase IDs

References (13)

Report Sections

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