FlyBase Allele Report: Dmel\dpp[d-ho]

General Information

Symbol

Dmel\dpp^d-ho

Species

D. melanogaster

Name

FlyBase ID

FBal0002997

Feature type

allele

Associated gene

Dmel\dpp

Associated Insertion(s)

Carried in Construct

Also Known As

dpp^ho2, dpp^ho, dpp^dho

Key Links

Allele class

Mutagen

spontaneous

Nature of the Allele

Allele class

Mutagen

spontaneous

Progenitor genotype

Cytology

Polytene chromosomes normal.

(Segal and Gelbart, 1985, Gelbart, 1982)

Description

3kb deletion of sequences 23kb 3' of the dpp transcription unit.

(Masucci et al., 1990)

2.7kb deletion.

(Irish and Gelbart, 1987)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible

(Gelbart, 1982)

visible (with dpp^s1)

(Chauhan et al., 2013)

visible | adult stage

(Koh et al., 2023)

visible | recessive

(Irish and Gelbart, 1987)

Phenotype Manifest In

posterior crossvein (with dpp^s1)

(Chauhan et al., 2013)

wing

(Koh et al., 2023, Horsfield et al., 1998, Gelbart, 1982)

wing vein L2 (with dpp^s1)

(Chauhan et al., 2013)

wing vein L4 (with dpp^s1)

(Chauhan et al., 2013)

Detailed Description

Statement

Reference

Flies homozygous for both dpp^s1 and dpp^d-ho display shortened L4, and occasionally, L2 and posterior crossveins.

(Chauhan et al., 2013)

Held out wings, no noticeable eye roughening.

(Horsfield et al., 1998)

dpp^s1 dpp^d-ho double mutant chromosome partially suppresses the penetrance of the hh^Mrt phenotype.

(Felsenfeld and Kennison, 1995)

dpp^hr4/dpp^d-ho transheterozygotes show a wild type wing phenotype in an otherwise normal genetic background.

(Sanicola et al., 1995)

Held out wing, defects in sensilla campaniforma on the wing blade.

(Masucci et al., 1990)

Complete wings, reduction of sensilla on the dorsal radius from 25 to 8 and an additional fold.

(Bryant, 1988)

Held out wing phenotype.

(Irish and Gelbart, 1987)

z¹ product subliminally inhibits the complementation of dpp^hr4 and dpp^d-ho. The effect is only seen when compounded by the particular effects of rearrangements on synapsis.

(Smolik-Utlaut and Gelbart, 1987)

Held-out wings. The wings are held out laterally instead of in line with the longitudinal axis of the body. Transheterozygotes with dpp^hr4 exhibit normally oriented wings.

(Gelbart, 1982)

Wings are held out laterally to the long axis of the body.

(Spencer et al., 1982)

Wings extended at right angles to body. RK1.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

dpp^d-ho/dpp^s1 has visible phenotype, enhanceable by Lpt¹/Lpt[+]

(Chauhan et al., 2013)

Enhancer of

Statement

Reference

dpp^d-ho/dpp^d-ho is an enhancer of increased cell death phenotype of ix¹

(Chatterjee et al., 2015)

Suppressor of

Statement

Reference

dpp^d-ho/dpp[+] is a suppressor of visible phenotype of Scer\GAL4^Tub.PU, csw^N308D.UASp

(Oishi et al., 2006)

dpp^d-ho is a suppressor of visible phenotype of upd1^GMR.PB

(Bach et al., 2003)

Other

Statement

Reference

dpp^d-ho, ix¹ has neoplasia phenotype

(Chatterjee et al., 2015)

dpp^d5/dpp^d-ho, ix¹ has neoplasia phenotype

(Chatterjee et al., 2015)

dpp^d-ho/dpp^d6, ix¹ has neoplasia phenotype

(Chatterjee et al., 2015)

dpp^d-ho, ix⁵ has neoplasia phenotype

(Chatterjee et al., 2015)

Lpt¹/Lpt[+], dpp^d-ho/dpp^s1 has visible phenotype

(Chauhan et al., 2013)

Df(2L)DTD52-D51, In(2LR)DTD11, dpp^d-ho/dpp^hr4 has visible phenotype

(Gelbart, 2001.4.19)

DTD45.10^45.10, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

DTD46.6^46.6, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

DTD44.3^44.3, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

DTD45.7^45.7, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

DTD46.5^46.5, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

DTD45.1^45.1, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

DTD46.8^46.8, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

DTD44.4^44.4, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

Ab(?)DTD44.2, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

Ab(?)DTD45.2, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

DTD44.5^44.5, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

DTD45.11^45.11, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

DTD45.8^45.8, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

Df(2L)C144, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

Dp(2;2)DTD45.12, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

In(2L)DTD46.3, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

In(2LR)DTD45.6, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

In(2LR)DTD46.2, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

In(2LR)DTD46.9, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

T(2;3)DTD43.3, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

T(2;3)DTD43.4, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

T(2;3)DTD43.5, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

T(2;3)DTD44.1, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

T(2;3)DTD45.3, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

T(2;3)DTD45.4, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

T(2;3)DTD45.5, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

T(2;3)DTD45.9, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

T(2;3)DTD46.4, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

T(2;3)DTD46.7, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

T(2;4)DTD43.1, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

In(2L)DTD42.0, dpp^d-ho/dpp^hr4 has visible phenotype

(Su et al., 2001)

dpp^d-ho/dpp^hr4, lilli^a16 has visible phenotype

(Su et al., 2001)

Phenotype Manifest In

Enhanced by

Statement

Reference

dpp^d-ho/dpp^s1 has posterior crossvein phenotype, enhanceable by Lpt¹/Lpt[+]

(Chauhan et al., 2013)

dpp^d-ho has phenotype, enhanceable by tld¹⁴

(Raftery et al., 1995)

NOT suppressed by

Statement

Reference

dpp^d-ho has phenotype, non-suppressible by su(Hw)²

(Lindsley and Grell, 1968)

Enhancer of

Statement

Reference

dpp^d-ho/dpp^d-ho is an enhancer of genital disc phenotype of ix¹

(Chatterjee et al., 2015)

Suppressor of

Statement

Reference

dpp^d-ho/dpp[+] is a suppressor of wing vein | ectopic phenotype of Scer\GAL4^Tub.PU, csw^N308D.UASp

(Oishi et al., 2006)

dpp^d-ho/dpp^d-ho is a suppressor of wing vein | ectopic phenotype of Snr1^R3/Snr1^E1

(Marenda et al., 2004)

dpp^d-ho is a suppressor of eye phenotype of upd1^GMR.PB

(Bach et al., 2003)

dpp^d-ho/dpp^d12 is a suppressor of eye phenotype of CycE^JP

(Horsfield et al., 1998)

dpp^d-ho/dpp^hr4 is a suppressor of eye phenotype of CycE^JP

(Horsfield et al., 1998)

dpp^d-ho/tkv^unspecified is a suppressor of phenotype of CycE^JP

(Horsfield et al., 1998)

dpp^d-ho/put^unspecified is a suppressor of phenotype of CycE^JP

(Horsfield et al., 1998)

dpp^d-ho/Mad^unspecified is a suppressor of phenotype of CycE^JP

(Horsfield et al., 1998)

Med^unspecified/dpp^d-ho is a suppressor of phenotype of CycE^JP

(Horsfield et al., 1998)

dpp^d-ho/shn^unspecified is a suppressor of phenotype of CycE^JP

(Horsfield et al., 1998)

dpp^d-ho is a suppressor of eye phenotype of CycE^JP

(Horsfield et al., 1998)

Other

Statement

Reference

dpp^d-ho, ix¹ has terminalia phenotype

(Chatterjee et al., 2015)

dpp^d5/dpp^d-ho, ix¹ has terminalia phenotype

(Chatterjee et al., 2015)

dpp^d-ho/dpp^d6, ix¹ has terminalia phenotype

(Chatterjee et al., 2015)

dpp^d-ho, ix⁵ has terminalia phenotype

(Chatterjee et al., 2015)

Lpt¹/Lpt[+], dpp^d-ho/dpp^s1 has wing vein L2 phenotype

(Chauhan et al., 2013)

Lpt¹/Lpt[+], dpp^d-ho/dpp^s1 has posterior crossvein phenotype

(Chauhan et al., 2013)

Df(2L)DTD52-D51, In(2LR)DTD11, dpp^d-ho/dpp^hr4 has wing phenotype

(Gelbart, 2001.4.19)

DTD45.10^45.10, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

DTD46.6^46.6, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

DTD44.3^44.3, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

DTD45.7^45.7, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

DTD46.5^46.5, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

DTD45.1^45.1, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

DTD46.8^46.8, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

DTD44.4^44.4, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

Ab(?)DTD44.2, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

Ab(?)DTD45.2, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

DTD44.5^44.5, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

DTD45.11^45.11, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

DTD45.8^45.8, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

Df(2L)C144, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

Dp(2;2)DTD45.12, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

In(2L)DTD46.3, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

In(2LR)DTD45.6, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

In(2LR)DTD46.2, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

In(2LR)DTD46.9, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

T(2;3)DTD43.3, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

T(2;3)DTD43.4, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

T(2;3)DTD43.5, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

T(2;3)DTD44.1, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

T(2;3)DTD45.3, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

T(2;3)DTD45.4, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

T(2;3)DTD45.5, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

T(2;3)DTD45.9, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

T(2;3)DTD46.4, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

T(2;3)DTD46.7, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

dpp^d-ho/dpp^hr4, lilli^a16 has wing phenotype

(Su et al., 2001)

T(2;4)DTD43.1, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

In(2L)DTD42.0, dpp^d-ho/dpp^hr4 has wing phenotype

(Su et al., 2001)

dpp^d-ho/dpp^hr4, en⁹⁶ has wing phenotype

(Sanicola et al., 1995)

Additional Comments

Genetic Interactions

Statement

Reference

A high frequency of tumour growth occurs below the anal plates of the terminalia in chromosomally female flies homozygous for ix⁵ and dpp^d-ho. In contrast, no major abnormalities are detected in the terminalia of XY ix¹ dpp^d-ho double homozygotes.

A high frequency of tumour growth occurs below the anal plates of the terminalia in chromosomally female flies homozygous for ix¹ and dpp^d-ho, or homozygous for ix¹ and trans-heterozygous for dpp^d5/dpp^d-ho or dpp^d6/dpp^d-ho.

Homozygosity for dpp^d-ho significantly enhances the number of cell deaths in ix¹ homozygous genital discs.

(Chatterjee et al., 2015)

Approximately 6% of flies trans-heterozygous for Lpt¹/dpp^s1 dpp^d-ho display a shortened posterior crossvein.

Lpt¹/+ flies homozygous for both dpp^s1 and dpp^d-ho show enhancement of the posterior crossvein phenotype relative to trans-heterozygotes, and shortened L2 and L4 veins.

(Chauhan et al., 2013)

In(2LR)DTD52, dpp^d-ho/In(2LR)DTD11, dpp^hr4 flies have wild-type wing posture. Df(2L)DTD52-D51, dpp^d-ho/In(2LR)DTD11, dpp^hr4 flies have a heldout wing posture.

(Gelbart, 2001.4.19)

dpp^d-ho/dpp^hr4 shows heldout wings in combination with In(2L)DTD42.0, T(2;4)DTD43.1, T(2;3)DTD43.3, T(2;3)DTD43.4, T(2;3)DTD43.5, T(2;3)DTD44.1, Ab(?)DTD44.2, DTD44.3^44.3, DTD44.4^44.4, DTD44.5^44.5, DTD45.1^45.1, Ab(?)DTD45.2, T(2;3)DTD45.3, T(2;3)DTD45.4, T(2;3)DTD45.5, In(2LR)DTD45.6, DTD45.7^45.7, DTD45.8^45.8, T(2;3)DTD45.9, DTD45.10^45.10, DTD45.11^45.11, Dp(2;2)DTD45.12, In(2LR)DTD46.2, In(2L)DTD46.3, T(2;3)DTD46.4, DTD46.5^46.5, DTD46.6^46.6, T(2;3)DTD46.7, DTD46.8^46.8, In(2LR)DTD46.9, Df(2L)C144 or lilli^a16.