FB2024_03 , released June 25, 2024
Allele: Dmel\Medunspecified
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General Information
Symbol
Dmel\Medunspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0090575
Feature type
allele
Associated gene
Dmel\Med
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        The number of T bars per active zone and bouton surface area per active zone is increased compared to wild type in the boutons of muscle 6/7 in mutant third instar larvae. 57 +/- 5% detachment of the presynaptic membrane is seen.

        (McCabe et al., 2004)

        Lethality is rescued by MedUbi-p63E.PD.

        (Das et al., 1998)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressor of
        Statement
        Reference

        Medunspecified/Med[+] is a suppressor of abnormal neuroanatomy phenotype of hiwEMS

        (McCabe et al., 2004)
        Phenotype Manifest In
        Suppressor of
        Statement
        Reference

        Medunspecified/Med[+] is a suppressor of bouton | increased number phenotype of hiwEMS

        (McCabe et al., 2004)

        Medunspecified/Med[+] is a suppressor of neuromuscular junction phenotype of hiwEMS

        (McCabe et al., 2004)

        Medunspecified/dppd-ho is a suppressor of phenotype of CycEJP

        (Horsfield et al., 1998)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        One copy of Medunspecified causes a moderate but significant reduction in the number of boutons per muscle surface area at the neuromuscular junction in hiwEMS homozygotes. The increase in bouton number at the neuromuscular junction seen in larvae expressing Scer\UBP2Scer\UAS.cDa under the control of Scer\GAL4elav.PLu in a wild-type background is not seen if they express Scer\UBP2Scer\UAS.cDa under the control of Scer\GAL4elav.PLu in a Medunspecified background.

        (McCabe et al., 2004)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        Medunspecified is rescued by MedUbi-p63E.PD

        (Das et al., 1998)
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        Medunspecified
        Name Synonyms
        Secondary FlyBase IDs
          References (3)