FB2024_03 , released June 25, 2024
Allele: Dmel\fl(2)d1
Open Close
General Information
Symbol
Dmel\fl(2)d1
Species
D. melanogaster
Name
FlyBase ID
FBal0004018
Feature type
allele
Associated gene
Dmel\fl(2)d
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

antimorphic allele - genetic evidence

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

antimorphic allele - genetic evidence

(Penn et al., 2008)

hypomorphic allele - genetic evidence

(Granadino et al., 1992)
Mutagen
ethyl methanesulfonate
(Granadino et al., 1992, Granadino et al., 1990)
Progenitor genotype
Cytology

Polytene chromosomes normal.

(Granadino et al., 1992)
Description

Nucleotide substitution: G939A. Amino acid replacement: D180N.

(Penalva et al., 2000)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:13,821,303..13,821,303 [-]
Nucleotide change:

G13821303A

Reported nucleotide change:

G939A|FBrf0127272

Amino acid change:

D177N | fl(2)d-PA; D53N | fl(2)d-PB; D53N | fl(2)d-PC; D53N | fl(2)d-PD

Reported amino acid change:

D180N|FBrf0127272

Comment:

translation of the reference sequence results in a protein 3 amino acids shorter than the one predicted from accession GB:AJ243599 and in FBrf0127272

(Penalva et al., 2000)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      fl(2)d1 homozygotes are female lethal.

      (Haussmann et al., 2016)

      fl(2)d1/+ suppresses position effect variegation at the w locus caused by P{SUPor-P}KV00108.

      (Swenson et al., 2016)

      Does not interact with Sxldlf, fl(1)3535, fl(1)3546 or l(1)4343.

      (Anand et al., 1998)

      Males are semi-lethal at 29oC and females are semi-lethal at 18oC. fl(2)d1/fl(2)d2 heterozygotes are female lethal at 29oC and females have reduced viability at 18oC.

      (Hilfiker et al., 1994)

      50% of homozygous males and no homozygous females survive at 29oC. Lethality is during the larval stage (animals can survive until the third instar stage). 75% of homozygous males and 16% of homozygous females survive at 18oC. The females that survive at 18oC are sterile (males are fertile at both temperatures). The temperature sensitive period in females is the whole of development. fl(2)d1/fl(2)d2 females show temperature-sensitive lethality, and males show temperature-sensitive semi-lethality. The lethality of homozygous and fl(2)d1/fl(2)d2 females is partially suppressed by SxlM1. The semi-lethality of homozygous and fl(2)d1/fl(2)d2 males is independent of Sxl function. The lethality of SxlM1 males is partially suppressed in homozygous fl(2)d1 and fl(2)d1/fl(2)d2 flies. Partially suppresses the female germline phenotype of ovoD1rv23 flies.

      (Granadino et al., 1992)

      Lethal in females and semi-lethal in males at 29oC, semi-lethal in females and nearly fully viable in males at 18oC. Homozygous adult females have reduced viability at both 18oC and 29oC, although females shifted to 29oC die earlier than flies kept at 18oC. Homozygous females also carrying SxlM1 have normal viability. Homozygous adult males have normal viability at both 18oC and 29oC, and have a slower developmental rate than wild-type. Homozygous females are inseminated less than wild-type females, this phenotype is suppressed by SxlM1. Homozygous males are able to inseminate females. Homozygous females developing at 18oC are sterile, with oogenesis arrested at the previtellogenic stages. This sterility is suppressed by SxlM1.

      (Granadino et al., 1991)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      fl(2)d1 has lethal | recessive | female phenotype, suppressible | partially by Mettl3Delta22-3/Ime4[+]

      (Haussmann et al., 2016)
      Suppressor of
      Statement
      Reference

      fl(2)d[+]/fl(2)d1 is a suppressor of partially lethal | dominant | female phenotype of SxlN.Hsp83.lacZ

      (Penn et al., 2008)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The female lethality characteristic for fl(2)d1 homozygotes is rescued to a high degree by combination with a single copy of Ime4Δ22-3.

      (Haussmann et al., 2016)

      The reduced viability of females carrying SxlN.Hsp83.T:Ecol\lacZ is completely suppressed by fl(2)d1/+.

      The female progeny of fl(2)d1/+ females mated to SxlfP7B0/Y males show only 65.3% viability.

      The female progeny of snfJ210/+ ; fl(2)d1/+ females mated to SxlfP7B0/Y males show only 27.6% viability.

      The female progeny of snf148/+ ; fl(2)d1/+ females mated to SxlfP7B0/Y males show only 11.1% viability.

      The female progeny of snfJ210/+ ; fl(2)d1/+ ; snf5MER females mated to SxlfP7B0/Y males show 16.1% viability.

      The female progeny of U2af38ΔE18/fl(2)d1 females mated to SxlfP7B0/Y males show only 25.8% viability.

      (Penn et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      fl(2)dP

      (Penalva et al., 2000)
      Rescued by

      fl(2)d1 is rescued by fl(2)dβTub56D.PP

      (Penalva et al., 2000)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      The amount of RNA transcribed from the dosage-compensated X-linked Sgs4 gene compared with that transcribed from the autosomal Sgs3 gene in fl(2)d1 heterozygotes and homozygotes has been measured. It shows that fl(2)d1 affects dosage compensation; it causes hypertranscription of the two X chromosomes in females.

      (Granadino et al., 1990)

      Germline clonal analysis suggests that fl(2)d1 autonomously affects the development of the germline.

      (Granadino et al., 1992)

      Homozygous larvae and heteroallelic larvae with fl(2)d2, reared at 25oC, have msl-1 and mle associated with numerous sites along the paired X chromosomes.

      (Hilfiker et al., 1994)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      fl(2)d1
      (Anand et al., 1998)
      fl(2)d1
      (Kan et al., 2017, Haussmann et al., 2016, Swenson et al., 2016, Penn et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (13)