FlyBase Allele Report: Dmel\ftz[10]

General Information

Symbol

Dmel\ftz¹⁰

Species

D. melanogaster

Name

FlyBase ID

FBal0004815

Feature type

allele

Associated gene

Dmel\ftz

Associated Insertion(s)

Carried in Construct

Also Known As

ftz^r14

Key Links

Allele class

loss of function allele

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Duncan, 1986, Wakimoto et al., 1984)

loss of function allele

Mutagen

ethyl methanesulfonate

(Lewis et al., 1980)

Progenitor genotype

Cytology

Polytene chromosomes normal.

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Lewis et al., 1980)

lethal - all die during embryonic stage

(Wakimoto et al., 1984)

some die during embryonic stage

(Wakimoto et al., 1984)

Phenotype Manifest In

embryo | dorsal closure stage

(Wakimoto et al., 1984)

embryonic epidermis

(Bender et al., 1987)

hypostomal sclerite

(Wakimoto et al., 1984)

presumptive embryonic/larval central nervous system

(Wakimoto et al., 1984)

presumptive embryonic/larval nervous system

(Bender et al., 1987)

Detailed Description

Statement

Reference

ftz¹⁰/Df(3R)Scr show abnormal segmentation of the germ band, with at least half the segments missing. The segmentation of the ventral nerve cord is also affected. The labial lobe cannot be seen, and the H piece of the larval mouthparts is missing in late embryos. Dorsal closure is disrupted.

(Wakimoto et al., 1984)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

ftz¹⁰ has epidermis phenotype, enhanceable by hb^D1

(Bender et al., 1987)

ftz¹⁰ has nervous system phenotype, enhanceable by hb^D1

(Bender et al., 1987)

Enhancer of

Statement

Reference

ftz¹⁰ is an enhancer of phenotype of hb^D1

(Bender et al., 1987)

ftz¹⁰ is an enhancer of phenotype of hb^D2

Additional Comments

Genetic Interactions

Statement

Reference

In double mutant with hb^D1 segmentation defects approximate to the expectations of simple additivity of the two mutants but the cuticular element defects and nervous system defects are more severe.

(Bender et al., 1987)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

R. Lewis.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

EfR14

(Denell, 1994)

EfW14

(Lewis et al., 1980)

ftz¹⁰

(Zhai et al., 2009)

ftz^R14

(Duncan, 1986)

ftz^r14

(Bender et al., 1987, Wakimoto et al., 1984)

ftz^rf10

(Bowler et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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