FB2024_03 , released June 25, 2024
Allele: Dmel\fu37
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General Information
Symbol
Dmel\fu37
Species
D. melanogaster
Name
FlyBase ID
FBal0004870
Feature type
allele
Associated gene
Dmel\fu
Associated Insertion(s)
Carried in Construct
Also Known As
fu2P
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Preat et al., 1993, Perrimon and Mahowald, 1987)
Progenitor genotype
Cytology
Description

Class II fu allele, affects the carboxy domain of the protein by changing the open reading frame in the 5' region.

(Preat et al., 1993)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Abnormal oogenesis. Some of the eggs derived from homozygous germline clones arrest at early cleavage stages. Embryos that complete gastrulation begin to show a mild pattern of aberrant cell death but show near normal segmentation. Homozygous females are associated with a germline-dependent ovarian tumour phenotype that increases with age.

      (Perrimon and Mahowald, 1987)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      fu37 has phenotype, enhanceable by Su(fu)LP

      (Preat et al., 1993)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      When in combination with Su(fu)LP heterozygotes individuals die as pupae. Adult escapers display wings, halteres and legs that have duplication of structures in the anterior compartment and shortening along the proximal-distal axis. Embryos derived from heterozygotes with Su(fu) mutants display a segment polarity phenotype: thoracic denticle belts are absent, last two rows of abdominal denticle belts are absent and a mirror image duplication of anterior rows of abdominal denticle belts.

      (Preat et al., 1993)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Perrimon.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      fu2P
      (Preat et al., 1993, Perrimon and Mahowald, 1987)
      fu37
      Name Synonyms
      Secondary FlyBase IDs
        References (2)