FlyBase Allele Report: Dmel\g[1]

General Information

Symbol

Dmel\g¹

Species

D. melanogaster

Name

FlyBase ID

FBal0004957

Feature type

allele

Associated gene

Dmel\g

Associated Insertion(s)

?{}g¹

Carried in Construct

Also Known As

garnet¹

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

spontaneous

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Lloyd et al., 2002)

Mutagen

spontaneous

Progenitor genotype

Associated Insertion(s)

?{}g¹

Cytology

Description

4kb insertion in g.

(Lloyd et al., 1999)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Parkinson's disease 8

modeled by Lrrk¹

(Inoshita et al., 2022)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal behavior | recessive

(Kretzschmar et al., 2000)

abnormal courtship behavior | male

(Lloyd et al., 2002)

abnormal eye color

(Lloyd et al., 2002, Lloyd et al., 1999, Tearle, 1991)

abnormal eye color (with Df(1)HA92)

(Lloyd et al., 2002)

abnormal eye color | recessive

(Kretzschmar et al., 2000)

short lived | male

(Simonsen et al., 2007)

Phenotype Manifest In

Malpighian tubule

(Lloyd et al., 1999)

pigment cell

(Kretzschmar et al., 2000, Lloyd et al., 1999, Tearle, 1991)

testis sheath

(Lloyd et al., 1999)

Detailed Description

Statement

Reference

Mutant flies show a reduction in survival on a glycerol only food source compared to control flies.

(Wightman et al., 2012)

Mutant flies show some decrease in ommochrome pigment levels and a significant reduction in drosopterin pigment levels compared to wild type.

(Harris et al., 2011)

Mutant males have a shortened adult life span compared to controls, with a mean life span of 27.41 days at 25^o.

(Simonsen et al., 2007)

g¹ mutant females have 57% red pigment in the eye compared to 100% in wild-type flies. g¹/Df(1)HA92 mutants have lower levels of red eye pigment than g¹ homozygous mutants. g¹ mutant male flies show a greater degree of male-male courtship than wild-type flies.

(Lloyd et al., 2002)

Eye colour: the drosopterin (red pigment) content of g¹ flies is reduced compared to wild type. Eye colour: the drosopterin (red pigment) content of g¹ rb¹ double mutant flies is reduced to 18% of wild type. Eye colour: the xanthommatin (brown pigment) content of g¹ flies is reduced to 58% of wild type. Eye colour: the xanthommatin (brown pigment) content of g¹ rb¹ double mutant flies is reduced to 41% of wild type. Mutant flies show disturbed orientation behaviour and walking speed in a behavioural assay.

(Kretzschmar et al., 2000)

Eye colour: red pigments are reduced to 57 +/- 2% of wild-type levels, brown pigments are reduced to 25 +/- 3% of wild-type levels in females. Red pigments are reduced to 72 +/- 4% of wild-type levels, brown pigments are reduced to 66 +/- 1% of wild-type levels in males. Malpighian tubule colour: colourless (wild-type colour is orange). Testis colour: pale yellow (wild-type colour is bright yellow).

(Lloyd et al., 1999)

Lightly pigmented eyes and some pigment deposition in the ocelli.

(Tearle, 1991)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

g¹ has abnormal eye color phenotype, enhanceable by w^e(g)

(Lloyd et al., 2002)

Df(1)HA92/g¹ has abnormal eye color phenotype, enhanceable by w[+]/w^e(g)

(Lloyd et al., 2002)

g¹ has abnormal eye color phenotype, enhanceable by Df(1)N-8/+

(Lloyd et al., 2002)

g¹ has abnormal eye color phenotype, enhanceable by Df(1)N-8/w^e(g)

(Lloyd et al., 2002)

Enhancer of

Statement

Reference

g[+]/g¹ is an enhancer of chemical sensitive phenotype of Gk1^RNAi.UAS, Scer\GAL4^c564

(Wightman et al., 2012)

NOT Enhancer of

Statement

Reference

g[+]/g¹ is a non-enhancer of abnormal neuroanatomy | larval stage phenotype of Nak^RNAi.UAS, Scer\GAL4^109(2)80

(Yang et al., 2011)

Other

Statement

Reference

Rab32^ltd-1, g¹ has abnormal eye color phenotype

(Silva and Mensua, 1985)

Phenotype Manifest In

Enhanced by

Statement

Reference

Df(1)HA92/g¹ has pigment cell phenotype, enhanceable by w[+]/w^e(g)

(Lloyd et al., 2002)

g¹ has pigment cell phenotype, enhanceable by Df(1)N-8/+

(Lloyd et al., 2002)

g¹ has pigment cell phenotype, enhanceable by Df(1)N-8/w^e(g)

(Lloyd et al., 2002)

g¹ has pigment cell phenotype, enhanceable by w^e(g)/w^e(g)

(Lloyd et al., 2002)

g¹ has phenotype, enhanceable by w^e(g)

NOT Enhancer of

Statement

Reference

g[+]/g¹ is a non-enhancer of dendrite | larval stage phenotype of Nak^RNAi.UAS, Scer\GAL4^109(2)80

(Yang et al., 2011)

g[+]/g¹ is a non-enhancer of dendritic arborizing neuron | larval stage phenotype of Nak^RNAi.UAS, Scer\GAL4^109(2)80

(Yang et al., 2011)

Other

Statement

Reference

Rab32^ltd-1, g¹ has pigment cell phenotype

(Silva and Mensua, 1985)

Additional Comments

Genetic Interactions

Statement

Reference

The glycerol hypersensitivity of flies expressing Gyk^{dsRNA.Scer\UAS} under the control of Scer\GAL4^c564 (seen as a reduction in survival on a glycerol only food source) is enhanced if the flies are also heterozygous for g¹.

(Wightman et al., 2012)

The reduction in drosopterin pigment levels seen in flies carrying w^dsRNA.GMR is enhanced manyfold if they are also mutant for g¹.

(Harris et al., 2011)

The reduction in the number of dendritic endpoints of dorsal dendritic arborisation neurons which is seen in larvae expressing Nak^{dsRNA.Scer\UAS} under the control of Scer\GAL4^109(2)80 is not enhanced by g¹/+.

(Yang et al., 2011)

g¹ is a complex modifier of the eye phenotype caused by expression of bchs^EP2299 under the control of Scer\GAL4^GMR.PF.

(Simonsen et al., 2007)

The level of pteridine eye pigments in g¹ ; ltd¹ double mutant flies are significantly lower than that of the corresponding single mutants.

(Ma et al., 2004)

g¹, w^e(g) double mutant flies have significantly lower levels of red pigment in their eyes than g¹ single mutants. Likewise, Df(1)HA92/g¹, w^e(g)/+ mutants have lower levels of red pigment in the eye than Df(1)HA92/g¹ single mutants. Further, g¹, Df(1)N-8/+ double mutant flies have less red pigment in their eyes than the g¹, w^e(g) double mutants, while g¹, Df(1)N-8/w^e(g) flies have the least pigment of the mutant combinations described here.

(Lloyd et al., 2002)

Eye colour: nearly white, with ltd¹. Pale eye color due to the absence of pteridines and brown pigment.

(Silva and Mensua, 1985)

Eye colour: cho¹ g¹ eye colour is indistinguishable from g¹.

(Sturtevant, 1955)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

g^Mc19-1

(Ripoll, 1977)

Comments

Images (2)

Holtzman, S. and Kaufman, T. (2013)

Mutant

Wild-type

Stocks (13)

Bloomington

3958

g¹

6888

tsg⁴ g¹/FM7c

4314

sov^A1304-1 g¹ f¹/FM7c

4657

l(1)2Cc² sn³ m¹ g¹/FM7a

4668

l(1)3Da⁵ sn³ m¹ g¹/FM7a

4306

dec² sc¹ v²⁴ g¹ f¹/FM3

936

Df(1)64c18, g¹ sd¹/Dp(1;2;Y)w⁺/C(1)DX, y¹ w¹ f¹

4923

Hk¹ g¹ sd¹ l(1)15Dc^R3 f¹/C(1)DX, y¹ w¹ f¹; Dp(1;4)r⁺/+

4922

Hk¹ g¹ sd¹ l(1)15Bb^R31 f¹/C(1)DX, y¹ w¹ f¹; Dp(1;4)r⁺/+

6027

y¹ ac¹ sc¹ pn¹ w¹ rb¹ cm¹ ct¹ sn³ ras⁴ v¹ m¹ g¹ f¹ car¹/FM6

Kyoto

107533

g¹

108921

Df(1)64c18, g¹ sd¹/Dp(1;2;Y)w⁺/C(1)DX, y¹ w¹ f¹

More stocks available...

Notes on Origin

Discoverer

Bridges, 19th Feb. 1915.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

(Sturtevant, 1955)

g¹

(Wightman et al., 2012, Harris et al., 2011, Popodi et al., 2010-, Christensen et al., 2009.7.22, Christensen et al., 2008.6.11, Falcon-Perez et al., 2007)

garnet¹

(Inoshita et al., 2022, Yang et al., 2011, Simonsen et al., 2007)

Name Synonyms

Secondary FlyBase IDs

References (24)

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