FlyBase Allele Report: Dmel\hry[22]

General Information

Symbol

Dmel\hry²²

Species

D. melanogaster

Name

FlyBase ID

FBal0005339

Feature type

allele

Associated gene

Dmel\hry

Associated Insertion(s)

Carried in Construct

Also Known As

h^C1

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Brown et al., 1995, Paroush et al., 1994, Brown et al., 1991)

Mutagen

ethyl methanesulfonate

(Wainwright and Ish-Horowicz, 1992, Ingham et al., 1985)

Progenitor genotype

Cytology

Polytene chromosomes normal.

(Ingham et al., 1985)

Description

Nucleotide substitution: C?T.

(Wainwright and Ish-Horowicz, 1992)

Amino acid replacement: R43term.

(Wainwright and Ish-Horowicz, 1992)

run protein produced is truncated, terminating in the basic region.

(Brown et al., 1991)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:8,677,399..8,677,399 [+]

Nucleotide change:

C8677399T

Reported nucleotide change:

C?T

Amino acid change:

R43term | h-PA; R43term | h-PB

Reported amino acid change:

R43term

(Wainwright and Ish-Horowicz, 1992)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal

lethal | recessive

(Ma et al., 1996, Wainwright and Ish-Horowicz, 1992, Ingham et al., 1985)

Phenotype Manifest In

neuron

(Sturtevant and Bier, 1995)

presumptive embryonic salivary gland

(Myat and Andrew, 2002)

presumptive embryonic salivary gland (with hry⁶⁷⁴)

(Myat and Andrew, 2002)

Detailed Description

Statement

Reference

Homozygous embryos have abnormally shaped salivary glands; 15% have elongated, branched lumens, 40% have elongated, expanded lumens, 37.5% have short, expanded lumens, 2.5% show no invagination and 5% are normal (elongated, unbranched lumens). h²²/h⁶⁷⁴ embryos have salivary glands with either branched or expanded lumens.

(Myat and Andrew, 2002)

h²²/gro^E48 double heterozygotes differentiate ectopic microchaete along the wing vein 2.

(Heitzler et al., 1996)

emc¹ h²² clones display differentiated photoreceptors that arise in a more anterior position that in adjacent wild type tissue, the morphogenetic furrow has been shifted anteriorly.

(Brown et al., 1995)

Extra neuron mutant.

(Sturtevant and Bier, 1995)

Legs from h^cosh; h^-/h^- adults show a bristle patterning defect that correlates with the expression pattern of h in pupal leg imaginal discs.

(Orenic et al., 1993)

h²² mutant clones in the eye have very few defective ommatidia.

(Brown et al., 1991)

Class IV allele: has a strong segmentation phenotype either when homozygous or in trans with h²⁵, and fails to complement the bristle phenotype of h¹.

(Ingham et al., 1985)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Other

Statement

Reference

emc¹, hry²² has eye disc morphogenetic furrow phenotype

(Zelhof et al., 1997)

Additional Comments

Genetic Interactions

Statement

Reference

emc¹ h²² double homozygous clones in the eye imaginal disc that intersect the morphogenetic furrow from the posterior, have an anteriorly shifted morphogenetic furrow.

(Zelhof et al., 1997)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

5529

108280

Notes on Origin

Discoverer

Comments

Selected on the basis of its failure to complement the bristle phenotype of either h¹ or h².

(Ingham et al., 1985)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

h²²

(Tanaka-Matakatsu et al., 2014, Christensen et al., 2009.6.15, Christensen et al., 2008.9.29)

h^C1

(Joshi et al., 2006, Cadigan et al., 2002, Heitzler et al., 1996, Ma et al., 1996, Brown et al., 1995, Sturtevant and Bier, 1995, Paroush et al., 1994, Orenic et al., 1993, Wainwright and Ish-Horowicz, 1992, Brown et al., 1991)

h^c1

(Zelhof et al., 1997, Ingham et al., 1985)

hry²²

Name Synonyms

hairy22

(Tanaka-Matakatsu et al., 2014)

Secondary FlyBase IDs

References (17)

Report Sections

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