FB2024_03 , released June 25, 2024
Allele: Dmel\hry674
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General Information
Symbol
Dmel\hry674
Species
D. melanogaster
Name
FlyBase ID
FBal0141098
Feature type
allele
Associated gene
Dmel\hry
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Myat and Andrew, 2002)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous embryos have abnormally shaped salivary glands; 40% have elongated, branched lumens, 30% have elongated, expanded lumens, 2% have short, expanded lumens and 28% are normal (elongated, unbranched lumens). The branching is due to defects in the early morphogenetic movements of salivary gland invagination; more cells appear to invaginate than normal. As in wild type, there is no cell proliferation within the salivary glands at all stages of salivary gland formation. Salivary gland cells of mutant embryos have increased apical areas compared to wild type. h22/h674, h25/h674 and hi22/h674 embryos have salivary glands with either branched or expanded lumens.

      (Myat and Andrew, 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      hkb2 h674 double mutant embryos form salivary glands that are morphologically identical to those of hkb2 single mutants, although there is an increase in salivary glands that fail to internalise (from 0% in the single mutants to 19% in the double mutants).

      (Myat and Andrew, 2002)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      hry674 is partially rescued by Scer\GAL4fkh.PH/hryUAS.cIa

      (Myat and Andrew, 2002)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      h674
      hry674
      Name Synonyms
      Secondary FlyBase IDs
        References (2)