FlyBase Allele Report: Dmel\hth[5E04]

General Information

Symbol

Dmel\hth^5E04

Species

D. melanogaster

Name

FlyBase ID

FBal0005553

Feature type

allele

Associated gene

Dmel\hth

Associated Insertion(s)

Carried in Construct

Also Known As

hth^5E

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Rieckhof et al., 1997)

Progenitor genotype

Cytology

Description

No point mutation within the coding sequence has been identified.

(Kurant et al., 2001)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage | recessive

(Rieckhof and Mann, 1996, Tearle and Nusslein-Volhard, 1987)

some die during embryonic stage | recessive

(Rieckhof and Mann, 1996, Tearle and Nusslein-Volhard, 1987)

visible | somatic clone

(Joulia et al., 2006)

Phenotype Manifest In

embryonic abdominal segment 1

(Rieckhof et al., 1997)

embryonic mesothoracic segment

(Tearle and Nusslein-Volhard, 1987)

embryonic metathoracic segment

(Tearle and Nusslein-Volhard, 1987)

embryonic prothoracic segment

(Tearle and Nusslein-Volhard, 1987)

larval abdominal lch5 neuron

(Kurant et al., 2001)

mesothoracic dorsal triscolopidial chordotonal organ dch3 & neuron

(Kurant et al., 2001)

mesothoracic ventral denticle belt

(Tearle and Nusslein-Volhard, 1987)

metathoracic dorsal triscolopidial chordotonal organ dch3 & neuron

(Kurant et al., 2001)

metathoracic ventral denticle belt

(Tearle and Nusslein-Volhard, 1987)

presumptive embryonic/larval peripheral nervous system

(Kurant et al., 2001)

prothoracic dorsal triscolopidial chordotonal organ dch3 & neuron

(Kurant et al., 2001)

prothoracic ventral denticle belt

(Tearle and Nusslein-Volhard, 1987)

pseudotrachea | somatic clone

(Joulia et al., 2006)

Detailed Description

Statement

Reference

Single cell class IV dendrite arborisation (da) neuron clones that are homozygous for hth^5E04 do not show defects in the establishment or maintenance of dendritic tiling.

(Parrish et al., 2007)

Homozygous clones in the labium result in a reduction of pseudotracheal rows.

(Joulia et al., 2006)

Homozygous embryos show a reduction in the number of LCh5 neurons, loss of thoracic DCh3 neurons and an abnormal pattern of the axonal trajectories in the PNS.

(Kurant et al., 2001)

The normal pattern of the cuticle is disrupted in homozygous embryos and hth^5E04/Df(3R)hth embryos, with hth^5E04/Df(3R)hth embryos having a stronger phenotype than homozygous embryos. The first abdominal segment is transformed to an identity resembling the third abdominal segment in homozygous embryos.

(Rieckhof et al., 1997)

Mutation does not affect the level of w expression in ph-p^lac+3 flies.

(Fauvarque et al., 1995)

The thoracic segments of hth^5E04 embryos appear similar to each other, with denticles intermediate between those normally found on segments T1 and T2.

(Tearle and Nusslein-Volhard, 1987)

embryonic lethal. Thoracic segments of embryo similar to one another; morphology of denticle bands intermediate between that of normal first and second thoracic segments.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Scr², hth^5E04, pb²⁷ has visible | somatic clone phenotype

(Joulia et al., 2006)

Scr², hth^5E04, pb²⁷, put^p1, ss^a has visible | somatic clone phenotype

(Joulia et al., 2006)

Scr^unspecified, hth^5E04, pb^unspecified, ss^unspecified has visible | somatic clone phenotype

(Joulia et al., 2006)

Scr², hth^5E04, pb²⁷, put^p1 has visible | somatic clone phenotype

(Joulia et al., 2006)

Phenotype Manifest In

Suppressor of

Statement

Reference

hth^5E04 is a suppressor of eye phenotype of CycE^JP

(Brumby et al., 2002)

Other

Statement

Reference

Scr², hth^5E04, pb²⁷ has leg | ectopic | somatic clone phenotype

(Joulia et al., 2006)

Scr², hth^5E04, pb²⁷, put^p1, ss^a has leg | ectopic | somatic clone phenotype

(Joulia et al., 2006)

Scr², hth^5E04, pb²⁷, put^p1, ss^a has labellum | somatic clone phenotype

(Joulia et al., 2006)

Scr^unspecified, hth^5E04, pb^unspecified, ss^unspecified has leg | ectopic | somatic clone phenotype

(Joulia et al., 2006)

Scr^unspecified, hth^5E04, pb^unspecified, ss^unspecified has labellum | somatic clone phenotype

(Joulia et al., 2006)

Scr², hth^5E04, pb²⁷ has antenna | ectopic | somatic clone phenotype

(Joulia et al., 2006)

Scr², hth^5E04, pb²⁷ has unguis | ectopic | somatic clone phenotype

(Joulia et al., 2006)

Scr², hth^5E04, pb²⁷ has labellum | somatic clone phenotype

(Joulia et al., 2006)

Scr², hth^5E04, pb²⁷ has bract | ectopic | somatic clone phenotype

(Joulia et al., 2006)

Scr², hth^5E04, pb²⁷ has arista | ectopic | somatic clone phenotype

(Joulia et al., 2006)

Scr², hth^5E04, pb²⁷, put^p1 has labellum | somatic clone phenotype

(Joulia et al., 2006)

Scr², hth^5E04, pb²⁷, put^p1 has arista | ectopic | somatic clone phenotype

(Joulia et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

pb²⁷ Scr² hth^5E04 clones in the labium result in transformation of the labium to a compact leg appendage identified by claws and bracted bristles in 81% of cases, while in the remaining 19% of cases the transformed structure contains a mix of leg and antennal tissue.

pb^unspecified Scr^unspecified hth^5E04 ss^unspecified mutant clones in the labium result in a 100% penetrant transformation of labium to stunted legs. These legs have claws and appear to be composed of three segments, but show no sign of tarsal articulation.

pb²⁷ Scr² hth^5E04 put^p1 clones in the labium show transformation to antennal aristae in 76% of cases and mixed transformations are not seen.

pb²⁷ Scr² hth^5E04 put^p1 ss^a clones in the labium show a fully penetrant transformation to stunted legs.

(Joulia et al., 2006)

Mutant weakly suppresses the CycE^JP rough eye phenotype.

(Brumby et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

hth^B2

(Rieckhof et al., 1997)

hth^C1

(Rieckhof et al., 1997)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

4221

ru¹ hry¹ Diap1^th-1 st¹ hth^5E04 cu¹ sr¹ e^s ca¹/TM3, Sb¹

Kyoto

107641

ru¹ hry¹ Diap1^th-1 st¹ hth^5E04 cu¹ sr¹ e^s ca¹/TM3, Sb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

hth¹

hth^5E04

(Clarembaux-Badell et al., 2022, Stratmann and Thor, 2017, Gabilondo et al., 2016, Bivik et al., 2015, Moris-Sanz et al., 2015, Estacio-Gómez et al., 2013, Karlsson et al., 2010, Christensen et al., 2008.4.15, Parrish et al., 2007)

hth^5E

(Joulia et al., 2006, Kurant et al., 2001, Rieckhof et al., 1997, Tearle and Nusslein-Volhard, 1987)

Name Synonyms

Secondary FlyBase IDs

References (18)

Report Sections

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